Zobrazeno 1 - 10
of 96
pro vyhledávání: '"David N Furness"'
Autor:
Jacqueline A Tickle, Jon Sen, Christopher Adams, David N Furness, Rupert Price, Viswapathi Kandula, Nikolaos Tzerakis, Divya M Chari
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 5, Pp 1057-1061 (2023)
The use of live animal models for testing new therapies for brain and spinal cord repair is a controversial area. Live animal models have associated ethical issues and scientific concerns regarding the predictability of human responses. Alternative m
Externí odkaz:
https://doaj.org/article/fc1c757151c443d69fc5c2e6bdcffe83
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185285 (2017)
Mechanosensory transduction by vertebrate hair cells depends on a protein complex at the tips of shorter stereocilia associated with mechanoelectrical transduction channels activated by tip links in the hair bundle. In mammalian hair cells, this comp
Externí odkaz:
https://doaj.org/article/8943a73677f345cf850fa5d4f3299425
Autor:
Valeria Zampini, Lukas Rüttiger, Stuart L Johnson, Christoph Franz, David N Furness, Jörg Waldhaus, Hao Xiong, Carole M Hackney, Matthew C Holley, Nina Offenhauser, Pier Paolo Di Fiore, Marlies Knipper, Sergio Masetto, Walter Marcotti
Publikováno v:
PLoS Biology, Vol 9, Iss 4, p e1001048 (2011)
Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into electrical signals depends upon mechanosensitive hair bundles that project from the cell's apical surface. Each stereoci
Externí odkaz:
https://doaj.org/article/f1f480656edf4f8baf0c7d15e540c68d
Autor:
Kumar N Alagramam, Richard J Goodyear, Ruishuang Geng, David N Furness, Alexander F J van Aken, Walter Marcotti, Corné J Kros, Guy P Richardson
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19183 (2011)
Immunocytochemical studies have shown that protocadherin-15 (PCDH15) and cadherin-23 (CDH23) are associated with tip links, structures thought to gate the mechanotransducer channels of hair cells in the sensory epithelia of the inner ear. The present
Externí odkaz:
https://doaj.org/article/af12369a59c14234825c2c698e648e37
Autor:
Adam J. Carlton, Jing-Yi Jeng, Fiorella C. Grandi, Francesca De Faveri, Ana E. Amariutei, Lara De Tomasi, Andrew O’Connor, Stuart L. Johnson, David N. Furness, Steve D.M. Brown, Federico Ceriani, Michael R. Bowl, Mirna Mustapha, Walter Marcotti
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114025- (2024)
Summary: Type I spiral ganglion neurons (SGNs) convey sound information to the central auditory pathway by forming synapses with inner hair cells (IHCs) in the mammalian cochlea. The molecular mechanisms regulating the formation of the post-synaptic
Externí odkaz:
https://doaj.org/article/003f391f46fe499b876a09eda87c4a9d
Autor:
David N. Furness
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Cochlear fibrocytes are a homeostatic supporting cell type embedded in the vascularized extracellular matrix of the spiral ligament, within the lateral wall. Here, they participate in the connective tissue syncytium that enables potassium recirculati
Externí odkaz:
https://doaj.org/article/852cd456585b4ff4bb1bda3fb144a4a8
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Transmembrane channel-like protein 1 (TMC1) is thought to form the ion-conducting pore of the mechanoelectrical transducer (MET) channel in auditory hair cells. Using single-channel analysis and ionic permeability measurements, we characterized six m
Autor:
Shanthini Mahendrasingam, Anya Osborn, Muhammad Zubair Israr, Kiran Riasat, Rachel VA Gater, Andrea Spano, Desire Gogo-Fyneface, Amy J Worrall, David N Furness
Spiral ligament fibrocytes of the cochlea play homoeostatic roles in hearing and their degeneration contributes to hearing loss. Culturing fibrocytes in vitro provides a way to evaluate their functional characteristics and study possible therapies fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7939e675aa15ba0b7b3492eb86dec67d
https://eprints.keele.ac.uk/10472/1/HEARES-D-21-00232_R1-5.pdf
https://eprints.keele.ac.uk/10472/1/HEARES-D-21-00232_R1-5.pdf
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Transmembrane channel like protein 1 (TMC1) is likely to be a pore-forming subunit of the transduction channel of cochlear hair cells that is mechanically gated by tension on tip links in the stereocilia bundle. To localise TMC1 precisely, we labelle
Autor:
David N. Furness, Stuart L. Johnson, Mirna Mustapha, Sara Wells, Michael R. Bowl, Adam J Carlton, Jing-Yi Jeng, Walter Marcotti, Lara De Tomasi, Matthew C. Holley, Francesca De Faveri, Steve D. M. Brown, Richard J. Goodyear, Guy P. Richardson
Publikováno v:
J Physiol
KEY POINTS: Age-related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure). Currently, we know very little about age-related changes occurrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7346221ac5c690cdec1f8d2991c3bc5f
https://eprints.keele.ac.uk/9605/1/JP279795.pdf
https://eprints.keele.ac.uk/9605/1/JP279795.pdf