Zobrazeno 1 - 10
of 130
pro vyhledávání: '"David N Church"'
Autor:
Gareth Evans, Tjalling Bosse, David N Church, Noel de Miranda, James Bolton, Neil Ryan, Emma Crosbie, Thomas Walker, Marieke Ijsselsteijn, Mark Glaire, Natalja ter Haar
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective To explore the impact of molecular subtype in endometrial cancer (EC) on CD8+T cell densities. Furthermore, this work will test the assumption that all mismatch repair deficient (MMRd) tumours are immunologically similar which would enable
Externí odkaz:
https://doaj.org/article/0d7d9326c85c4ec0a50f47499e3953a4
Autor:
Anja L Frei, Anthony McGuigan, Ritik RAK Sinha, Mark A Glaire, Faiz Jabbar, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim J Iveson, Mark Saunders, Karin Oein, Noori Maka, Francesco Pezella, Leticia Campo, Jennifer Hay, Joanne Edwards, Owen J Sansom, Caroline Kelly, Ian Tomlinson, Wanja Kildal, Rachel S Kerr, David J Kerr, Håvard E Danielsen, Enric Domingo, TransSCOT Consortium, David N Church, Viktor H Koelzer
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 6, Pp 449-463 (2023)
Abstract Multiplex immunofluorescence (mIF) imaging can provide comprehensive quantitative and spatial information for multiple immune markers for tumour immunoprofiling. However, application at scale to clinical trial samples sourced from multiple i
Externí odkaz:
https://doaj.org/article/d2fd350d290249e6b38f3b09f966ff54
Autor:
Frances Elmslie, Anna Kim, Kevin J Monahan, Francesca Faravelli, Fiona Lalloo, David N Church, Jackie Cook, Tracie Miles, Neil Ryan, Steven A Hardy, Sally Lane, Alaa Elghobashy, Laura Monje-Garcia, Adam C Shaw, Simone Gelinas, Adele Tyson, Ruth Armstrong, Frank D McDermott, Valerie Ya Wen Wang
Publikováno v:
BMJ Oncology, Vol 2, Iss 1 (2023)
Objective In England, through the Genomic Medicine Service Alliances (GMSAs), a national transformation project aims to embed robust pathways to deliver universal Lynch syndrome (LS) testing for patients with colorectal and endometrial cancers. Prior
Externí odkaz:
https://doaj.org/article/358da55ca3114dd4a47d74308a5c3a0d
Autor:
Matthew Brown, Alicia Leon, Katarzyna Kedzierska, Charlotte Moore, Hayley L Belnoue‐Davis, Susanne Flach, John P Lydon, Francesco J DeMayo, Annabelle Lewis, Tjalling Bosse, Ian Tomlinson, David N Church
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 10, Pp n/a-n/a (2023)
Abstract High‐risk endometrial cancer has poor prognosis and is increasing in incidence. However, understanding of the molecular mechanisms which drive this disease is limited. We used genetically engineered mouse models (GEMM) to determine the fun
Externí odkaz:
https://doaj.org/article/5c8f6de2c4ae45eeb10187d03d135ae1
Autor:
Antonia K Roseweir, James H Park, Sanne ten Hoorn, Arfon GMT Powell, Susan Aherne, Campbell SD Roxburgh, Donald C McMillan, Paul G Horgan, Elizabeth Ryan, Kieran Sheahan, Louis Vermeulen, James Paul, Andrea Harkin, Janet Graham, Owen Sansom, David N Church, Ian Tomlinson, Mark Saunders, Tim J Iveson, Joanne Edwards
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 4, Pp 283-296 (2020)
Abstract Histological ‘phenotypic subtypes’ that classify patients into four groups (immune, canonical, latent and stromal) have previously been demonstrated to stratify survival in a stage I–III colorectal cancer (CRC) pilot cohort. However, c
Externí odkaz:
https://doaj.org/article/86ccccce88334b4890153382c13043e0
Autor:
Dan Jiang, Tarjei S. Hveem, Mark Glaire, David N. Church, David J. Kerr, Li Yang, Håvard E. Danielsen
Publikováno v:
EBioMedicine, Vol 71, Iss , Pp 103547- (2021)
Background: Tumor development is critically dependent on the supporting stroma consisting of inflammatory cells and fibroblasts. This study intended to improve prognostic prediction for early colorectal cancer (CRC) by combined estimation of T-lympho
Externí odkaz:
https://doaj.org/article/baeeb2c3ab634364ab37fa6521d1cd05
Autor:
Andreas Kleppe, Ole-Johan Skrede, Sepp De Raedt, Tarjei S Hveem, Hanne A Askautrud, Jørn E Jacobsen, David N Church, Arild Nesbakken, Neil A Shepherd, Marco Novelli, Rachel Kerr, Knut Liestøl, David J Kerr, Håvard E Danielsen
Publikováno v:
The Lancet Oncology. 23:1221-1232
The DoMore-v1-CRC marker was recently developed using deep learning and conventional haematoxylin and eosin-stained tissue sections, and was observed to outperform established molecular and morphological markers of patient outcome after primary color
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68aabdd911ec7fe62df057931bfd6949
https://doi.org/10.1016/s1470-2045(22)00391-6
https://doi.org/10.1016/s1470-2045(22)00391-6
Autor:
Anja Laura Frei, Anthony McGuigan, Ritik RAK Sinha, Mark A Glaire, Faiz Jabbar, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim Iveson, Mark Saunders, Karin Oien, Noori Maka, Francesco Pezzella, Leticia Campo, Jennifer Hay, Joanne Edwards, Owen Sansom, Caroline Kelly, Ian Tomlinson, Wanja Kildal, Rachel Kerr, David Kerr, Havard Emil Danielsen, Enric Domingo, David N Church, Viktor Hendrik Koelzer
Background: Tumour immunoprofiling captures tumour-microenvironment interactions and enables precision medicine. Multiplex immunofluorescence (mIF) imaging can provide comprehensive quantitative and spatial information for multiple immune markers. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f8335b8a6f4dafad80bfbed52bc50e1
https://doi.org/10.1101/2023.05.19.23290216
https://doi.org/10.1101/2023.05.19.23290216
Autor:
David N. Church, Viktor H. Koelzer, Hans W. Nijman, Tjalling Bosse, Carien L. Creutzberg, Vincent T. Smit, Elzbieta M. van der Steen-Banasik, Jan J. Jobsen, Ludy C.H.W. Lutgens, Ina M. Jürgenliemk-Schulz, Michelle Osse, Kirsten D. Mertz, Annechien Plat, Alicia León-Castillo, Katarzyna Kedzierska, Ellen Stelloo, Remi A. Nout, Marco de Bruyn, Nanda Horeweg
Supplementary Tables 1-14 and Supplementary Figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053d0ebe34ebd8afd1aefeb61f40f9a1
https://doi.org/10.1158/2326-6066.22543677.v1
https://doi.org/10.1158/2326-6066.22543677.v1
Autor:
David N. Church, Viktor H. Koelzer, Hans W. Nijman, Tjalling Bosse, Carien L. Creutzberg, Vincent T. Smit, Elzbieta M. van der Steen-Banasik, Jan J. Jobsen, Ludy C.H.W. Lutgens, Ina M. Jürgenliemk-Schulz, Michelle Osse, Kirsten D. Mertz, Annechien Plat, Alicia León-Castillo, Katarzyna Kedzierska, Ellen Stelloo, Remi A. Nout, Marco de Bruyn, Nanda Horeweg
Optimum risk stratification in early-stage endometrial cancer combines clinicopathologic factors and the molecular endometrial cancer classification defined by The Cancer Genome Atlas (TCGA). It is unclear whether analysis of intratumoral immune infi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598b00a1fe1b6386eaf503615b4db1bd
https://doi.org/10.1158/2326-6066.c.6550359
https://doi.org/10.1158/2326-6066.c.6550359