Zobrazeno 1 - 10
of 95
pro vyhledávání: '"David N Arnosti"'
Publikováno v:
eLife, Vol 5 (2016)
Enhancers constitute one of the major components of regulatory machinery of metazoans. Although several genome-wide studies have focused on finding and locating enhancers in the genomes, the fundamental principles governing their internal architectur
Externí odkaz:
https://doaj.org/article/72f5df3e34a94926a1e811df1bf78999
Autor:
Walid D Fakhouri, Ahmet Ay, Rupinder Sayal, Jacqueline Dresch, Evan Dayringer, David N Arnosti
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-14 (2010)
Abstract Systems biology seeks a genomic‐level interpretation of transcriptional regulatory information represented by patterns of protein‐binding sites. Obtaining this information without direct experimentation is challenging; minor alterations
Externí odkaz:
https://doaj.org/article/04c2703be2cd4bb2b009d2493588bc2c
Publikováno v:
eLife, Vol 4 (2015)
Metazoan transcriptional repressors regulate chromatin through diverse histone modifications. Contributions of individual factors to the chromatin landscape in development is difficult to establish, as global surveys reflect multiple changes in regul
Externí odkaz:
https://doaj.org/article/d5413889ac80477fa9f45f3149d196ad
Publikováno v:
bioRxiv
The C-terminal Binding Protein (CtBP) is a transcriptional corepressor that plays critical roles in development, tumorigenesis, and cell fate. CtBP proteins are structurally similar to alpha hydroxyacid dehydrogenases and additionally feature an unst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831a64e9e5328981fafb0e37a5fb851e
https://europepmc.org/articles/PMC10245716/
https://europepmc.org/articles/PMC10245716/
Publikováno v:
bioRxiv
Retinoblastoma tumor suppressor proteins are highly conserved transcriptional corepressors, regulating the key transition from G1 to S phase of the cell cycle. The mammalian Rb family is composed of Rb, p107, and p130, which possess both overlapping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df6de09c4538898f1bde924fe79fa66
https://doi.org/10.1101/2023.05.19.541454
https://doi.org/10.1101/2023.05.19.541454
Autor:
Ana-Maria Raicu, Dhruva Kadiyala, Madeline Niblock, Aanchal Jain, Yahui Yang, Kalynn M Bird, Kayla Bertholf, Akshay Seenivasan, Mohammad Siddiq, David N Arnosti
Publikováno v:
Molecular Biology and Evolution. 40
Evolution of sequence-specific transcription factors clearly drives lineage-specific innovations, but less is known about how changes in the central transcriptional machinery may contribute to evolutionary transformations. In particular, transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44039fbdd7dd1f01869ff50e52c93335
https://doi.org/10.1093/molbev/msad003
https://doi.org/10.1093/molbev/msad003
Autor:
Ana-Maria Raicu, Dhruva Kadiyala, Madeline Niblock, Aanchal Jain, Yahui Yang, Kalynn M. Bird, Kayla Bertholf, Akshay Seenivasan, David N. Arnosti
Evolution of sequence-specific transcription factors clearly drives lineage-specific innovations, but less is known about how changes in the central transcriptional machinery may contribute to evolutionary transformations. In particular, transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcbdf751c5832d2ceadcb88fd9e8dea5
https://doi.org/10.1101/2022.06.23.497424
https://doi.org/10.1101/2022.06.23.497424
Autor:
Stephen Small, David N. Arnosti
Publikováno v:
Genetics. 216:1-26
Key discoveries in Drosophila have shaped our understanding of cellular “enhancers.” With a special focus on the fly, this chapter surveys properties of these adaptable cis-regulatory elements, whose actions are critical for the complex spatial/t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0594a2f18d6c3c57210d866fe9f6890
https://doi.org/10.1534/genetics.120.301370
https://doi.org/10.1534/genetics.120.301370
Publikováno v:
Structure
C-terminal binding proteins 1 and 2 (CtBP1 and CtBP2) are transcriptional regulators that activate or repress many genes involved in cellular development, apoptosis and metastasis. CtBP proteins are activated under hypoxic conditions where NAD(H) lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f420841a0be814ec5d6c7850d4626c
https://doi.org/10.1016/j.str.2021.03.006
https://doi.org/10.1016/j.str.2021.03.006
Autor:
Kurtulus eKok, David N. Arnosti
Publikováno v:
Frontiers in Genetics, Vol 6 (2015)
Temporal and spatial control of transcription in development is dictated to a great extent by transcriptional repressors. Some repressor complexes, such as Polycomp-group proteins, induce relatively long-term non-permissive states, whereas others suc
Externí odkaz:
https://doaj.org/article/d609a028144f4451ad910eb37be3ba4b