Zobrazeno 1 - 10
of 129
pro vyhledávání: '"David N, Zacks"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-9 (2024)
Abstract Due to the large number of genes and mutations that result in inherited retinal degenerations (IRD), there has been a paucity of therapeutic options for these patients. There is a large unmet need for therapeutic approaches targeting shared
Externí odkaz:
https://doaj.org/article/bfe6b0e9b11b494ead3b40ac372e4949
Autor:
Steven F. Abcouwer, Bruna Miglioranza Scavuzzi, Phillip E. Kish, Dejuan Kong, Sumathi Shanmugam, Xuan An Le, Jingyu Yao, Heather Hager, David N Zacks
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract The retinal pigment epithelium (RPE) maintains photoreceptor viability and function, completes the visual cycle, and forms the outer blood-retinal barrier (oBRB). Loss of RPE function gives rise to several monogenic retinal dystrophies and c
Externí odkaz:
https://doaj.org/article/487206ebf56c47e6aeee4f489f4822ae
Autor:
Paloma B. Liton, Kathleen Boesze-Battaglia, Michael E. Boulton, Patricia Boya, Thomas A. Ferguson, Ian G. Ganley, Anu Kauppinnen, Gordon W. Laurie, Noboru Mizushima, Hideaki Morishita, Rossella Russo, Jaya Sadda, Rajalekshmy Shyam, Debasish Sinha, Debra A. Thompson, David N. Zacks
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through the lysosomal compartment. Although first believed to function in conditions of nutritional stress, autophagy is emerging
Externí odkaz:
https://doaj.org/article/061946d58aef4da69c2648d6e73ee4f8
Autor:
David N Zacks, Joshua D Stein, Omar Moinuddin, Rebhi O Abuzaitoun, Min W Hwang, Sanjana K Sathrasala, Xing D Chen, Mark W Johnson, Thomas J Wubben, Cagri G Besirli
Publikováno v:
BMJ Open Ophthalmology, Vol 6, Iss 1 (2021)
Objective To report anatomic and visual outcomes of pars plana vitrectomy (PPV), as well as scleral buckling (SB) and PPV/SB as surgical treatments for the management of primary, non-complex rhegmatogenous retinal detachment (RRD).Methods and analysi
Externí odkaz:
https://doaj.org/article/952f3820ff054e9d90a4bca173e0dab0
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 11, Pp 991-991 (2022)
Externí odkaz:
https://doaj.org/article/38bfc1d4c10746d5a662766db5cac49d
Autor:
Anitha Krishnan, Andrew J. Kocab, David N. Zacks, Ann Marshak-Rothstein, Meredith Gregory-Ksander
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Glaucoma is a complex, multifactorial disease where apoptosis, microglia activation, and inflammation have been linked to the death of retinal ganglion cells (RGCs) and axon degeneration. We demonstrated previously that FasL-Fas s
Externí odkaz:
https://doaj.org/article/414b24d38f60448292315ecd971e04c6
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 70 (2021)
Inherited retinal degenerations (IRD) are a leading cause of visual impairment and can result from mutations in any one of a multitude of genes. Mutations in the light-sensing protein rhodopsin (RHO) is a leading cause of IRD with the most common of
Externí odkaz:
https://doaj.org/article/58da0e2f028e4f3b851f8567954f695a
Autor:
Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Heather M. Hager, Steven F. Abcouwer, David N. Zacks
Publikováno v:
Cells, Vol 10, Iss 8, p 2010 (2021)
After retinal detachment (RD), the induction of autophagy protects photoreceptors (PR) from apoptotic cell death. The cytoplasmic high-mobility group box 1 (HMGB1) promotes autophagy. We previously demonstrated that the deletion of HMGB1 from rod PRs
Externí odkaz:
https://doaj.org/article/53b1126dcf584204b32b40395a0911cf
Autor:
David N. Zacks, Shahzad I. Mian, Peter Yu Cheng Zhao, Bradford L. Tannen, David C. Musch, Katie X Li, Asad Farooq Durrani, Yunshu Zhou
Publikováno v:
Cornea. 41:1345-1352
Purpose The purpose of this study was to investigate the clinical features, surgical outcomes, and prognostic factors of penetrating keratoplasty (PKP) after open globe injury (OGI). Methods A retrospective review of all patients treated for OGI betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6732e1d3b538f814ddab15a174b411f9
https://doi.org/10.1097/ico.0000000000002918
https://doi.org/10.1097/ico.0000000000002918
Autor:
Nicholas M. Carducci, Thomas J Wubben, Katie X Li, Omar Moinuddin, Cagri G. Besirli, David N. Zacks
Publikováno v:
Ophthalmic Surgery, Lasers and Imaging Retina. 52:593-600
BACKGROUND AND OBJECTIVE: To investigate the effect of the coronavirus disease 2019 (COVID-19) lockdown on the presentation and management of acute, primary rhegmatogenous retinal detachment (RRD). PATIENTS AND METHODS: This was a single-center, cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5392dafb3079f838c099e1def33bbb
https://doi.org/10.3928/23258160-20211015-01
https://doi.org/10.3928/23258160-20211015-01