Zobrazeno 1 - 10
of 34
pro vyhledávání: '"David N, Young"'
Autor:
Warren T. Jahn, Jeffrey R. Cates, Jesse P. Armine, David N. Young, Robert C. Porter, Daniel S. Bowerman, Alan B. Korbett, Robert A. King, Terry D. Sandman, David J. Guerriero
Publikováno v:
Journal of Manipulative and Physiological Therapeutics. 26:282-286
Objective To evaluate the quality of Recommended Clinical Protocols and Guidelines for the Practice of Chiropractic (ICA guidelines) published by the International Chiropractors Association (ICA), August, 2000. Methods The Appraisal Instrument for Cl
Autor:
John A. Schmidt, Linda A. Egger, Daniel Scott, Michael A. Wallace, Mark Cornebise, Gail Van Riper, Allen N. Jones, David N. Young, Richard A. Mumford, Usha Kidambi, Jin Cao, Thomas J. Lanza, Stephen E. de Laszlo, William K. Hagmann, Christine McCallum, R. Blake Pepinsky, Wen-Cherng Lee, Ginger X. Yang, Patricia A. Detmers, Linus S. Lin, Dennis C. Dean, Conrad E. Raab, Ermengilda McCauley
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:903-913
An α4β1/α4β7 dual antagonist, 35S-compound 1, was used as a model ligand to study the effect of divalent cations on the activation state and ligand binding properties of α4 integrins. In the presence of 1 mM each Ca2+/Mg2+, 35S-compound 1 bound
Autor:
Richard A. Mumford, William K. Hagmann, Karen Owens, Plato A. Magriotis, Gail Van Riper, David N. Young, Ermengilda McCauley, Sharon Tong, Linus S. Lin, Usha Kidambi, Stephen E. deLaszlo, Ralph A. Stearns, John A. Schmidt, Adria Colletti, Yohannes Teffera, Kathryn A. Lyons, Malcolm MacCoss, Linda A. Egger, Dorothy Levorse, Thomas J. Lanza, Ihor E. Kopka, Stella H. Vincent, Sander G. Mills
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2415-2418
A series of substituted N-(3,5-dichlorobenzenesulfonyl)-( l )-prolyl- and ( l )-azetidyl-β-biaryl β-alanine derivatives was prepared as selective and potent VLA-4 antagonists. The 2,6-dioxygenated biaryl substitution pattern is important for optimi
Autor:
Richard A. Mumford, Sharon Tong, Patricia A. Detmers, Evelyn E. Benson, Linus S. Lin, Sarah Warwood, David N. Young, John A. Schmidt, Ermengilda McCauley, Gail Van Riper, Usha Kidambi, Stephen E. de Laszlo, Russell B. Lingham, Robert F. Bargatze, Linda A. Egger, William K. Hagmann, Jin Cao, Bill Pikounis, Suzanne E Amo, Thomas J. Lanza, Ihor E. Kopka
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 302:153-162
The alpha(4) integrin, alpha(4)beta(7), plays an important role in recruiting circulating lymphocytes to the gastrointestinal tract, where its ligand mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is preferentially expressed on high endothelia
Autor:
Plato A. Magriotis, John A. Schmidt, Stella H. Vincent, Junying Wang, Linus S. Lin, Dorothy Levorse, Sharon Tong, Zhen Wang, Linda E Egger, Ihor E. Kopka, Richard A. Mumford, Sander G. Mills, William K. Hagmann, Ralph A. Stearns, David N. Young, Malcolm MacCoss, Usha Kidambi, Ermengilda McCauley, Kathryn A. Lyons, Karen Owens, Gail Van Riper, Song Zheng, Adria Colletti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:637-640
A series of substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl- and alpha-methyl-L-prolyl-phenylalanine derivatives was prepared as VLA-4/VCAM antagonists. The compounds showed excellent potency with a wide variety of neutral, polar, electron withd
Autor:
Linda L. Chang, Plato A. Magriotis, Theodore M. Kamenecka, John A. Schmidt, David N. Young, Ralph A. Stearns, Sharon Tong, Linda A. Egger, Philippe L. Durette, Adria Colletti, Ermengilda McCauley, Kathryn A. Lyons, Johannes Teffera, Richard A. Mumford, Jonathan E. Wilson, Stephen E. de Laszlo, Dorothy Levorse, Linus S. Lin, Judy Fenyk-Melody, Bing Li, Ginger X. Yang, Nancy J. Kevin, William K. Hagmann, Thomas J. Lanza, Malcolm MacCoss, Stella H. Vincent, Karen Owens, Gail Van Riper, Philip Kim, Ihor E. Kopka, Sander G. Mills, Usha Kidambi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2709-2713
Directed screening of a carboxylic acid-containing combinatorial library led to the discovery of potent inhibitors of the integrin VLA-4. Subsequent optimization by solid-phase synthesis afforded a series of sulfonylated dipeptide inhibitors with str
Autor:
Alan B. Korbett, David N. Young, Robert A. King, Daniel S. Bowerman, Jeffrey R. Cates, Jesse P. Armine, Robert C. Porter, David J. Guerriero, Warren T. Jahn, Terry D. Sandman
Publikováno v:
Journal of Manipulative and Physiological Therapeutics. 24:170-176
Objective: To review and identify established methods for evaluating the quality of practice guidelines and to use a selected assessment tool to assess 2 chiropractic practice guideline documents. Methods: A search of the medical literature was perfo
Publikováno v:
Photochemistry and Photobiology. 70:630-636
Ideal photosensitizers have long-wavelength absorption and strong tumor selectivity with rapid clearance from normal tissues. The telluroselenopyrylium dye 1 that absorbs light at 795 nm (epsilon = 285,000 M-1 cm-1) has a novel property that enhances
Publikováno v:
The Journal of Organic Chemistry. 63:5716-5721
Autor:
David N. Young, Michael R. Detty
Publikováno v:
The Journal of Organic Chemistry. 62:4692-4700
Hydrolyses of chalcogenopyrylium dyes 1−9 give product distributions that are both heteroatom and oxygen dependent. Under anaerobic or aerobic conditions at pH 8, hydrolyses of dyes 1−4, which each contain a pyrylium ring, give 2-pentene-1,5-dion