CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

Autor: Sandra Sanchez-Roige, Mariela V. Jennings, Hayley H. A. Thorpe, Jazlene E. Mallari, Lieke C. van der Werf, Sevim B. Bianchi, Yuye Huang, Calvin Lee, Travis T. Mallard, Samuel A. Barnes, Jin Yi Wu, Amanda M. Barkley-Levenson, Ely C. Boussaty, Cedric E. Snethlage, Danielle Schafer, Zeljana Babic, Boyer D. Winters, Katherine E. Watters, Thomas Biederer, andMe Research Team, James Mackillop, David N. Stephens, Sarah L. Elson, Pierre Fontanillas, Jibran Y. Khokhar, Jared W. Young, Abraham A. Palmer

Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to act prematurely and is associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association st

Externí odkaz: https://doaj.org/article/b47ec1bf7cc04d37956dc97a36fdfe9e

CADM2is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

Autor: Sandra Sanchez-Roige, Mariela V Jennings, Hayley H A Thorpe, Jazlene E Mallari, Lieke C van der Werf, Sevim B Bianchi, Calvin Lee, Travis T Mallard, Samuel A Barnes, Jin Yi Wu, Amanda M Barkley-Levenson, Ely C Boussaty, Cedric E Snethlage, Danielle Schafer, Zeljana Babic, Boyer D Winters, Katherine E Watters, Thomas Biederer, James Mackillop, David N Stephens, Sarah L Elson, Pierre Fontanillas, Jibran Y Khokhar, Jared W Young, Abraham A Palmer

Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to act prematurely and is associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association studies (GW

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b91e23c15578708c4b5e6be4dd0443b1
https://doi.org/10.1101/2022.01.29.22270095

Motivational effects of methylphenidate are associated with GABRA2 variants conferring addiction risk

Autor: Theodora eDuka, Claire I Dixon, Leanne eTrick, Hans S. Crombag, Sarah L King, David N Stephens

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 9 (2015)

Background: Variations in the GABRA2 gene, encoding α2 subunits of GABAA receptors, have been associated with risk for addiction to several drugs, but the mechanisms by which variations in non-coding regions of GABRA2 increase risk for addictions ar

Externí odkaz: https://doaj.org/article/2df5fd2af10248afac0a6e77d976d25d

Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration.

Autor: Claire I Dixon, Sophie E Walker, Sarah L King, David N Stephens

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47135 (2012)

Human genetic studies have suggested that polymorphisms of the GABRA2 gene encoding the GABA(A) α2-subunit are associated with ethanol dependence. Variations in this gene also convey sensitivity to the subjective effects of ethanol, indicating a rol

Externí odkaz: https://doaj.org/article/f17d3ccb7acd4a21aa2e919f117ecae6

Early life stress influences acute and sensitised responses of adult mice to cocaine by interacting with GABAA α2 receptor expression

Autor: Sophie E. Walker, Jeremy J. Lambert, David N. Stephens, Claire I. Dixon, Jerome D. Swinny, Sarah L. King, Delia Belelli

Publikováno v: Dixon, C I, Walker, S E, Swinny, J, Belelli, D, Lambert, J J, King, S L & Stephens, D N 2019, ' Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABA A α2 receptor expression ', Behavioural Pharmacology, vol. 30, no. 2-3, pp. 272-281 . https://doi.org/10.1097/FBP.0000000000000466

Early-life stress (ELS) is known to exert long-term effects on brain function, with resulting deleterious consequences for several aspects of mental health, including the development of addiction to drugs of abuse. One potential mechanism in humans i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff980cfb6862729a10b6f6b07f514a4