Zobrazeno 1 - 10
of 28
pro vyhledávání: '"David Moreno Delgado"'
Autor:
David Moreno Delgado, Thor C Møller, Jeanne Ster, Jesús Giraldo, Damien Maurel, Xavier Rovira, Pauline Scholler, Jurriaan M Zwier, Julie Perroy, Thierry Durroux, Eric Trinquet, Laurent Prezeau, Philippe Rondard, Jean-Philippe Pin
Publikováno v:
eLife, Vol 6 (2017)
Metabotropic glutamate receptors (mGluRs) are mandatory dimers playing important roles in regulating CNS function. Although assumed to form exclusive homodimers, 16 possible heterodimeric mGluRs have been proposed but their existence in native cells
Externí odkaz:
https://doaj.org/article/45f8031aa1ce42f587b4ebe1846baae1
Autor:
Pauline Scholler, Damien Nevoltris, Dimitri de Bundel, Simon Bossi, David Moreno-Delgado, Xavier Rovira, Thor C. Møller, Driss El Moustaine, Michaël Mathieu, Emilie Blanc, Heather McLean, Elodie Dupuis, Gérard Mathis, Eric Trinquet, Hervé Daniel, Emmanuel Valjent, Daniel Baty, Patrick Chames, Philippe Rondard, Jean-Philippe Pin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
G protein-coupled receptors are considered promising therapeutic targets. Here, the authors have identified nanobodies, or single-domain llama antibodies, that specifically enhance agonist-induced activity of a type of G protein-coupled receptor, the
Externí odkaz:
https://doaj.org/article/816648732d614ed3bfb0746f18dd9438
Autor:
Marta González-Sepúlveda, Muhammad Yusof Omar, Sally Hamdon, Guofen Ma, Santi Rosell-Vilar, Noora Raivio, Doaa Abass, Anna Martínez-Rivas, Miquel Vila, Jesús Giraldo, Montserrat Carrascal, Joaquín Abián, Carles Gil, Josefa Sabriá, Jordi Ortiz, David Moreno-Delgado
Publikováno v:
Neuropharmacology. 212
Synaptic events are important to define treatment strategies for brain disorders. In the present paper, freshly obtained rat brain striatal minces were incubated under different times and conditions to determine dopamine biosynthesis, storage, and ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf9e0f87b38f0742830ad82aa52e35a
https://pubmed.ncbi.nlm.nih.gov/35429504
https://pubmed.ncbi.nlm.nih.gov/35429504
Autor:
Marco Scarselli, Enric I. Canela, Estefanía Moreno, Antoni Cortés, Anna Chiarlone, Vicent Casadó, Peter J. McCormick, Lesley A. Howell, Silvia Ginés, Manuel Guzmán, Joaquin Botta, Jordi Alberch, Paola Gasperini, Mar Puigdellívol, Mar Rodríguez-Ruiz, Sergi Ferré, Carmen Lluis, David Moreno-Delgado
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3905babc729f37f859d23b9dc12aef3d
https://doi.org/10.7554/elife.51093.sa2
https://doi.org/10.7554/elife.51093.sa2
Autor:
Sergio González, David Moreno-Delgado, Estefanía Moreno, Kamil Pérez-Capote, Rafael Franco, Josefa Mallol, Antoni Cortés, Vicent Casadó, Carme Lluís, Jordi Ortiz, Sergi Ferré, Enric Canela, Peter J McCormick
Publikováno v:
PLoS Biology, Vol 10, Iss 6, p e1001347 (2012)
The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. Here w
Externí odkaz:
https://doaj.org/article/8bed974b365c4c47beb867828b5fe724
Publikováno v:
Journal of Clinical Investigation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::ba6fa4dec2568b15569da8c43c9aadcc
Autor:
David, Moreno-Delgado, Mar, Puigdellívol, Estefanía, Moreno, Mar, Rodríguez-Ruiz, Joaquín, Botta, Paola, Gasperini, Anna, Chiarlone, Lesley A, Howell, Marco, Scarselli, Vicent, Casadó, Antoni, Cortés, Sergi, Ferré, Manuel, Guzmán, Carmen, Lluís, Jordi, Alberch, Enric I, Canela, Silvia, Ginés, Peter J, McCormick
Publikováno v:
eLife
Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D1R over-activation, we present a strategy based on targeting complexes of D1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e8ccdef4c093837723fafb533f1b8a0
https://pubmed.ncbi.nlm.nih.gov/32513388
https://pubmed.ncbi.nlm.nih.gov/32513388
Autor:
Eric Trinquet, Jurriaan M. Zwier, Jean-Philippe Pin, Stéphanie Soldevila, Nathalie Lecat-Guillet, Geoffrey Donsimoni, David Moreno-Delgado, Cédric Chouvet, Ludovic Fabre, Laurent J. Lamarque, Pauline Scholler, Philippe Rondard, Fabienne Charrier-Savournin, Thomas Roux, Etienne Doumazane, Carine Monnier
Publikováno v:
Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2017, 13 (4), pp.372-380. ⟨10.1038/nchembio.2286⟩
Nature Chemical Biology, Nature Publishing Group, 2017, 13 (4), pp.372-380. ⟨10.1038/nchembio.2286⟩
International audience; Cell surface receptors represent a vast majority of drug targets. Efforts have been conducted to develop biosensors reporting their conformational changes in live cells for pharmacological and functional studies. Although För
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d12d6e110b5dd725741edeef25fe9b
https://doi.org/10.1038/nchembio.2286
https://doi.org/10.1038/nchembio.2286
Autor:
Irene, Sebastianutto, Elise, Goyet, Laura, Andreoli, Joan, Font-Ingles, David, Moreno-Delgado, Nathalie, Bouquier, Céline, Jahannault-Talignani, Enora, Moutin, Luisa, Di Menna, Natallia, Maslava, Jean-Philippe, Pin, Laurent, Fagni, Ferdinando, Nicoletti, Fabrice, Ango, M Angela, Cenci, Julie, Perroy
Publikováno v:
J Clin Invest
Dopamine receptor D1 modulates glutamatergic transmission in cortico-basal ganglia circuits and represents a major target of L-DOPA therapy in Parkinson’s disease. Here we show that D1 and metabotropic glutamate type 5 (mGlu5) receptors can form pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::249340453eee375f8b8fb47f956905f4
https://pubmed.ncbi.nlm.nih.gov/32039920
https://pubmed.ncbi.nlm.nih.gov/32039920
Autor:
Zara A. Sands, Brice Mullier, Isabelle Niespodziany, Eric Jnoff, David Moreno-Delgado, Christian Wolff, Dominique Swinnen, Véronique M. André, Philippe Ghisdal, Martyn Wood
Publikováno v:
CNS neurosciencetherapeutics. 25(4)
Aims Kv1.1 (KCNA1) channels contribute to the control of neuronal excitability and have been associated with epilepsy. Kv1.1 channels can associate with the cytoplasmic Kvβ1 subunit resulting in rapid inactivating A-type currents. We hypothesized th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50a77db6a8848dd800a28d64f3db11d
https://pubmed.ncbi.nlm.nih.gov/30242974
https://pubmed.ncbi.nlm.nih.gov/30242974