Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

Autor: David Mordasini, Anne Labarre, Carlos J. Alcaide-Corral, Laurent A. Decosterd, Chrismita Hegde, Ellen Neven, Mark G. MacAskill, Marc Maillard, Dany Spaggiari, Michel Burnier, David E. Newby, Geert J. Behets, Bastien Castagner, Mattias E. Ivarsson, Patrick C. D'Haese, Antonia E. Schantl, Victoria C. Beindl, Adriana Tavares, Roberto Maj, Anja Verhulst, Jean-Christophe Leroux, Olivier Phan

Publikováno v: Schantl, A E, Verhulst, A, Neven, E, Behets, G J, D'Haese, P C, Maillard, M, Mordasini, D, Phan, O, Burnier, M, Spaggiari, D, Decosterd, L A, MacAskill, M G, Alcaide-Corral, C J, Tavares, A A S, Newby, D E, Beindl, V C, Maj, R, Labarre, A, Hedge, C, Castagner, B, Ivarsson, M E & Leroux, J-C 2020, ' Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers ', Nature Communications, vol. 11, 721 . https://doi.org/10.1038/s41467-019-14091-4
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature communications, vol. 11, no. 1, pp. 721
Nature communications
Nature Communications, 11 (1)

Myo-inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification (VC), but with limited potency and low plasma exposure following bolus administration. Here we report the design of a series of inositol phosphate analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb9a8129d650ca324178fbd915550a3
https://www.pure.ed.ac.uk/ws/files/134711722/s41467_019_14091_4.pdf

ENaC activity in collecting ducts modulates NCC in cirrhotic mice

Autor: David Mordasini, Bruno Vogt, Michel Burnier, Johannes Loffing, Rohrbach Beatrice, Dominique Loffing-Cueni, Geneviève Escher, Marc Maillard, Edith Hummler

Publikováno v: Mordasini, David; Loffing-Cueni, Dominique; Loffing, Johannes; Rohrbach, Beatrice; Maillard, Marc; Hummler, Edith; Burnier, Michel; Escher, Geneviève; Vogt, Bruno (2015). ENaC activity in collecting ducts modulates NCC in cirrhotic mice. Pflügers Archiv : European journal of physiology, 467(12), pp. 2529-2539. Springer 10.1007/s00424-015-1711-7
Pflugers Arch
Pflügers Archiv : European Journal of Physiology, vol. 467, no. 12, pp. 2529-2539
Pflugers Arch.
Pflügers Archiv-European Journal of Physiology

Cirrhosis is a frequent and severe disease, complicated by renal sodium retention leading to ascites and oedema. A better understanding of the complex mechanisms responsible for renal sodium handling could improve clinical management of sodium retent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd82986f99725104ba6e3e9ebcf683f
https://doi.org/10.1007/s00424-015-1711-7

Regulation of pendrin by pH: dependence on glycosylation

Autor: Gilles Crambert, Aurélie Edwards, Alain Doucet, Anie Azroyan, David Mordasini, Kamel Laghmani

Publikováno v: Biochemical Journal
Biochemical Journal, 2011, 434 (1), pp.61-72. ⟨10.1042/BJ20101411⟩
Biochemical Journal, Portland Press, 2011, 434 (1), pp.61-72. ⟨10.1042/BJ20101411⟩

Mutations in the anion exchanger pendrin are responsible for Pendred syndrome, an autosomal recessive disease characterized by deafness and goitre. Pendrin is highly expressed in kidney collecting ducts, where it acts as a chloride/bicarbonate exchan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54358f180bb3fd211b5d6569b5dcd96d
https://doi.org/10.1042/bj20101411

Sodium retention and ascites formation in a cholestatic mice model: Role of aldosterone and mineralocorticoid receptor?

Autor: Alain Doucet, Bruno Vogt, Lydie Cheval, Martine Imbert-Teboul, David Mordasini, Daniel Ackermann

Publikováno v: Hepatology
Hepatology, 2007, 46 (1), pp.173-179. ⟨10.1002/hep.21699⟩
Hepatology, Wiley-Blackwell, 2007, 46 (1), pp.173-179. ⟨10.1002/hep.21699⟩

Renal sodium retention in experimental liver cirrhosis originates from the distal nephron sensitive to aldosterone. The aims of this study were to (1) determine the exact site of sodium retention along the aldosterone-sensitive distal nephron, and (2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e7420ffd3dacd2c645c21a231b1608
https://doi.org/10.1002/hep.21699

Tonicity-Responsive Enhancer Binding Protein Is an Essential Regulator of Aquaporin-2 Expression in Renal Collecting Duct Principal Cells

Autor: Pierre-Yves Martin, Jeong Ah Kim, Udo Hasler, H. Moo Kwon, David Mordasini, Un Sil Jeon, Eric Féraille

Publikováno v: Journal of the American Society of Nephrology. 17:1521-1531

Tonicity-responsive enhancer binding protein (TonEBP) plays a key role in protecting renal cells from hypertonic stress by stimulating transcription of specific genes. Under hypertonic conditions, TonEBP activity is enhanced via increased nuclear tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068a01e1ed82f2b791772c52c8889091
https://doi.org/10.1681/asn.2005121317