Zobrazeno 1 - 10
of 16
pro vyhledávání: '"David Mondaca‐Ruff"'
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Autophagy is a cellular process involved in the selective degradation and recycling of dysfunctional intracellular components. It plays a crucial role in maintaining cellular homeostasis and survival by removing damaged and harmful proteins, lipids,
Externí odkaz:
https://doaj.org/article/62d6fa4bf8f94a46b6257a865de96620
Autor:
David Mondaca-Ruff, Jaime A. Riquelme, Clara Quiroga, Ignacio Norambuena-Soto, Fernanda Sanhueza-Olivares, Paulina Villar-Fincheira, Tomás Hernández-Díaz, Nicole Cancino-Arenas, Alejandra San Martin, Lorena García, Sergio Lavandero, Mario Chiong
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
Hypertension is a disease associated to increased plasma levels of angiotensin II (Ang II). Ang II can regulate proliferation, migration, ROS production and hypertrophy of vascular smooth muscle cells (VSMCs). However, the mechanisms by which Ang II
Externí odkaz:
https://doaj.org/article/27a1269233424edf91bfb0926a375cc7
Autor:
Marina García-Miguel, Jaime A Riquelme, Ignacio Norambuena-Soto, Pablo E Morales, Fernanda Sanhueza-Olivares, Constanza Nuñez-Soto, David Mondaca-Ruff, Nicole Cancino-Arenas, Alejandra San Martín, Mario Chiong
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197210 (2018)
Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis factor-α (TNF-α). VSMC
Externí odkaz:
https://doaj.org/article/b0d6e8556f054aa1bafd24fa673ae7c3
Publikováno v:
Mammalian Genome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::055418a54d5f6e01183c7e34b03ba71e
https://doi.org/10.1007/s00335-023-09978-z
https://doi.org/10.1007/s00335-023-09978-z
Autor:
Jorge E. Jalil, María Paz Ocaranza, Ulises Novoa, David Mondaca-Ruff, Italo Mora, Patricio Araos, Cristian Yañez
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 26:724-735
Background: Thiazides are one of the most common antihypertensive drugs used for hypertension treatment and hydrochlorothiazide (HCTZ) is the most frequently used diuretic for hypertension treatment. The Rho/Rho-kinase (ROCK) path plays a key functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a245a97b208dd7b3eefc698a048b2cb
https://doi.org/10.1177/10742484211053109
https://doi.org/10.1177/10742484211053109
Autor:
David Mondaca‐Ruff, Clara Quiroga, Ignacio Norambuena‐Soto, Jaime A. Riquelme, Alejandra San Martin, Mario Bustamante, Sergio Lavandero, Mario Chiong
Publikováno v:
Journal of cellular and molecular medicine. 26(5)
Hypertension is associated with high circulating angiotensin II (Ang II). We have reported that autophagy regulates Ang II-induced vascular smooth muscle cell (VSMC) hypertrophy, but the mechanism mediating this effect is still unknown. Therefore, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3949571657d0603d659d804e20de9c
https://pubmed.ncbi.nlm.nih.gov/35118791
https://pubmed.ncbi.nlm.nih.gov/35118791
Publikováno v:
Circulation. 144
Introduction: Cardiovascular diseases are the leading cause of disability and death worldwide. The cyclin-dependent kinase 5 (CDK5) signaling pathway has been implicated in the regulation of SIRT1, a mammalian longevity regulator involved in the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0baf57311c6606966f298d6184d4d413
https://doi.org/10.1161/circ.144.suppl_1.12268
https://doi.org/10.1161/circ.144.suppl_1.12268
Autor:
Ignacio Norambuena-Soto, Mario Chiong, Fernanda Sanhueza-Olivares, Rosemarie Mellado, David Mondaca-Ruff, Nicole Cancino-Arenas, Raúl Vivar, Constanza Nuñez-Soto, Guillermo Díaz-Araya
Publikováno v:
BioScience Trends. 11:154-162
Fibroblasts play several homeostatic roles, including electrical coupling, paracrine signaling and tissue repair after injury. Fibroblasts have low secretory activity. However, in response to injury, they differentiate to myofibroblasts. These cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfcd32e73bf0cabd7cfeb7f024f9e31
https://doi.org/10.5582/bst.2017.01017
https://doi.org/10.5582/bst.2017.01017
Autor:
Pablo Castro, Jorge E. Jalil, Andrés Aylwin Azócar, María Paz Ocaranza, David Mondaca-Ruff, Mario Chiong, Evelyn Mendoza-Torres, Alejandra P. Oyarzún, Sergio Lavandero
Publikováno v:
Ther Adv Cardiovasc Dis
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
The renin–angiotensin system (RAS) is a key component of cardiovascular physiology and homeostasis due to its influence on the regulation of electrolyte balance, blood pressure, vascular tone and cardiovascular remodeling. Deregulation of this syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4489015c1d45bc196ead93e1fb4f790
https://doi.org/10.1177/1753944715597623
https://doi.org/10.1177/1753944715597623
Autor:
David Mondaca-Ruff, Rodrigo Troncoso, Soni Shaikh, Mario Chiong, Sergio Lavandero, Valentina Parra, Lorena García
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 48
Stromal-interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) plays a key role in mediating cardiomyocyte hypertrophy, both in vitro and in vivo. Moreover, there is growing support for the contribution of SOCE to the Ca2+ overload
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5489894b0af91cdfbb975da2cd423e27
https://pubmed.ncbi.nlm.nih.gov/29337250
https://pubmed.ncbi.nlm.nih.gov/29337250