A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation

Autor: Joshua J Peter, Helge M Magnussen, Paul A DaRosa, David Millrine, Stephen P Matthews, Frederic Lamoliatte, Ramasubramanian Sundaramoorthy, Ron R Kopito, Yogesh Kulathu

Publikováno v: The EMBO Journal. 41

Protein UFMylation, i.e., post-translational modification with ubiquitin-fold modifier 1 (UFM1), is essential for cellular and endoplasmic reticulum homeostasis. Despite its biological importance, we have a poor understanding of how UFM1 is conjugate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f13c92b89b4f7e58893f4e768a971d
https://doi.org/10.15252/embj.2022111015

Making sense of IL-6 signalling cues in pathophysiology

Autor: David Millrine, Robert H. Jenkins, Simon Jones, Stuart T. O. Hughes

Unravelling the molecular mechanisms that account for functional pleiotropy is a major challenge for researchers in cytokine biology. Cytokine-receptor cross-reactivity and shared signalling pathways are considered primary drivers of cytokine pleiotr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612bc4b30ffb24dcc80fdbd6e59ed0f4
https://orca.cardiff.ac.uk/id/eprint/144732/8/1873-3468.14201.pdf

Non canonical scaffold-type ligase complex mediates protein UFMylation

Autor: Joshua J. Peter, Helge M. Magnussen, Paul Anthony DaRosa, David Millrine, Stephen P Matthews, Frederic Lamoliatte, Ramasubramanian Sundaramoorthy, Ron R Kopito, Yogesh Kulathu

Protein UFMylation is emerging as a posttranslational modification essential for endoplasmic reticulum and cellular homeostasis. Despite its biological importance, we have a poor understanding of how UFM1 is conjugated onto substrates. Here, we use a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3819ab41288e8e19a2c2323d5d08546
https://doi.org/10.1101/2022.01.31.478489

Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells

Autor: Simon Arnett Jones, Jasmine Li, Florian Wiede, Michael J. Townsend, Gareth W. Jones, Xiao Liu, Costantino Pitzalis, Robert Andrews, Jason Peter Twohig, Alicia Derrac Soria, Philip R. Taylor, Javier Uceda Fernandez, Tony Tiganis, Barbara Szomolay, David Hill, Myles Lewis, Chris Pepper, Benjamin C. Cossins, Nigel Williams, Ana Cardus Figueras, David Millrine

Publikováno v: Twohig, J, Figueras, A C, Andrews, R, Wiede, F, Cossins, B, Soria, A D, Lewis, M, Townsend, M, Millrine, D, Hill, D, Fernandez, J U, Liu, X, Szomolay, B, Pepper, C, Taylor, P, Pitzalis, C, Tiganis, T, Williams, N, Jones, G, Jones, S & Li, J 2019, ' Activation of naïve CD4 + T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 + T cells ', Nature Immunology, vol. 20, no. 4, pp. 458-470 . https://doi.org/10.1038/s41590-019-0350-0

The cytokine IL-6 controls the survival, proliferation and effector characteristics of lymphocytes through activation of the transcription factors STAT1 and STAT3. While STAT3 activity is an ever-present feature of IL-6 signaling in CD4 + T cells, pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f2d84d1e02e30b242a82730c030eed
https://doi.org/10.1038/s41590-019-0350-0

A Brighter Side to Thalidomide: Its Potential Use in Immunological Disorders

Autor: Tadamitsu Kishimoto, David Millrine

Publikováno v: Trends in Molecular Medicine. 23:348-361

Thalidomide and its derivatives are immunomodulatory drugs (IMiDs) known for their sedative, teratogenic, anti-angiogenic, and anti-inflammatory properties. Commonly used in the treatment of cancers such as multiple myeloma and myelodysplastic syndro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afba26b723e20209cd3ff5fc020f2bd
https://doi.org/10.1016/j.molmed.2017.02.006