Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David Michel Adrien Taddei"'
Autor:
Matthew J. Schiewer, Susana Miranda, William West, Suzanne Carreira, Stuart Thomson, Gareth W. Harbottle, Ana Ferreira, Stuart Thomas Onions, Donald Smyth, Nigel Brooks, Jonathan Shannon, Jonathan Welti, Nina Tunariu, Johann S. de Bono, Christopher McNair, Jenny Worthington, Wei Yuan, Karen E. Knudsen, Adam Sharp, Barbara Young, Amy Prosser, Jan Rekowski, Su C, Rita Pereira, Amanda Swain, Jian Ning, Abhijit Pal, Jordan Lane, Ruth Riisnaes, Bora Gurel, Ines Figueiredo, Mateus Crespo, Richard J. C. Brown, Saswati N. Chand, David Michel Adrien Taddei, Denisa Bogdan, Veronica Gil, Silvia Paoletta, Meera Raja, Neil Anthony Pegg, Antje Neeb
Publikováno v:
Cancer discovery. 11(5)
Resistance to androgen receptor (AR) blockade in castration-resistant prostate cancer (CRPC) is associated with sustained AR signaling, including through alternative splicing of AR (AR-SV). Inhibitors of transcriptional coactivators that regulate AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbe14e20a3d6b9fa6c1304e667e02ff
https://pubmed.ncbi.nlm.nih.gov/33947717
https://pubmed.ncbi.nlm.nih.gov/33947717
Autor:
Kazuhiro Ito, Alun John Smith, Catherine Elisabeth Charron, Garth Rapeport, Fritz Frickel, Stuart Thomas Onions, Marie Colucci, Andrew Novak, Peter Strong, Kevin Joly, George Hardy, P. John Murray, David Michel Adrien Taddei, Richard James Brown, Yasuo Kizawa, Anjna Rani, Ian Knowles, Jonathan Gareth Williams, John King-Underwood
Publikováno v:
Journal of Medicinal Chemistry. 59:1727-1746
The discovery of a novel series of therapeutic agents that has been designed and optimized for treating chronic obstructive pulmonary disease is reported. The pharmacological strategy was based on the identification of compounds that inhibit a define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2066096c894114db7d281ae5538082d4
https://doi.org/10.1021/acs.jmedchem.5b01029
https://doi.org/10.1021/acs.jmedchem.5b01029
Publikováno v:
European Journal of Organic Chemistry. 2005:939-947
The synthetic potential of a novel precursor of 2,6-diaminopurine CDK inhibitors, 2-(benzylsulfanyl)-6-chloro-9-isopropylpurine, is described. The Traube purine synthesis was chosen to prepare the required 2-(benzylsulfanyl)hypoxanthine intermediate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa422a8aa39348aab498cbf437e2f016
https://doi.org/10.1002/ejoc.200400748
https://doi.org/10.1002/ejoc.200400748
Autor:
Jordan Lane, Matthew J. Schiewer, David Michel Adrien Taddei, Renee deLeeuw, Barbara Young, Jennifer J. McCann, Amy Prosser, Karen Knusden, Nigel Brooks, Jenny Worthington, Neil Anthony Pegg
Publikováno v:
Cancer Research. 77:1575-1575
Background: E1A binding protein (p300) and CREB binding protein (CBP) are two closely related, paralogue histone acetyl transferase proteins that act as transcriptional co-activators of a variety of cancer related genes. We have developed potent, sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd06bec15d7b5ca5cd0d8e178fdae64a
https://doi.org/10.1158/1538-7445.am2017-1575
https://doi.org/10.1158/1538-7445.am2017-1575
Autor:
Amy Prosser, Karen E. Knudsen, Gareth W. Harbottle, Jenny Worthington, Jordan Lane, Nigel Brooks, Richard J. C. Brown, David Michel Adrien Taddei, Barbara Young, Neil Anthony Pegg, Silvia Paoletta, Jonathan Shannon
Publikováno v:
Journal of Clinical Oncology. 35:11590-11590
11590 Background: Targeted degradation of androgen receptor (AR) and AR variants (ARV) remains an attractive therapeutic opportunity for patients with castrate resistant prostate cancer (CRPC). E1A binding protein (p300) and CREB binding protein (CBP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dc4d8b840f172c2b3e183359355d8f4
https://doi.org/10.1200/jco.2017.35.15_suppl.11590
https://doi.org/10.1200/jco.2017.35.15_suppl.11590
Autor:
Jordan Lane, Neil Anthony Pegg, David Michel Adrien Taddei, Nigel Brooks, Jenny Worthington, Karen E. Knudsen, Barbara Young, Nicolas Gordon, Matthew J. Schiewer, Amy Prosser
Publikováno v:
Journal of Clinical Oncology. 35:168-168
168 Background: Targeted degradation of androgen receptor (AR) and androgen receptor variants (ARV) remains an attractive therapeutic opportunity for patients with castrate resistant prostate cancer (CRPC). E1A binding protein (p300) and CREB binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf635dca6cae67e1195ba5345207741f
https://doi.org/10.1200/jco.2017.35.6_suppl.168
https://doi.org/10.1200/jco.2017.35.6_suppl.168
Publikováno v:
ChemInform. 40
Lanciaquinone, isolated from Maesa lanceolata, was originally assigned as a bisbenzoquinone with a C14-chain linking the two quinone rings. A synthesis of the reported structure, in which the key step is a double Claisen rearrangement, suggests that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c6cbb301c467ba88de74d86c86180ce
https://doi.org/10.1002/chin.200911208
https://doi.org/10.1002/chin.200911208
Publikováno v:
Organic letters. 10(20)
Lanciaquinone, isolated from Maesa lanceolata, was originally assigned as a bisbenzoquinone with a C14-chain linking the two quinone rings. A synthesis of the reported structure, in which the key step is a double Claisen rearrangement, suggests that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf7122197c49cdaa520aef21c86ef49
https://pubmed.ncbi.nlm.nih.gov/18785746
https://pubmed.ncbi.nlm.nih.gov/18785746
Publikováno v:
Organicbiomolecular chemistry. 2(5)
A simple and efficient synthesis of 6-chloro-2-iodopurine from hypoxanthine has been achieved. This strategy relied on a regiospecific lithiation/quenching sequence of 6-chloro-9-(tetrahydropyran-2-yl)purine using Harpoon's base and tributyltin chlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831a8060a3924536f7abf7ce60803194
https://pubmed.ncbi.nlm.nih.gov/14985806
https://pubmed.ncbi.nlm.nih.gov/14985806
Publikováno v:
Scopus-Elsevier
ARKIVOC-Online Journal of Organic Chemistry
ARKIVOC-Online Journal of Organic Chemistry, 2007, 11, pp.56-63. ⟨10.3998/ark.5550190.0008.b05⟩
ARKIVOC-Online Journal of Organic Chemistry, Arkat USA Inc, 2007, 11, pp.56-63. ⟨10.3998/ark.5550190.0008.b05⟩
ARKIVOC, Vol 2007, Iss 11, Pp 56-63 (2006)
ResearcherID
ARKIVOC-Online Journal of Organic Chemistry
ARKIVOC-Online Journal of Organic Chemistry, 2007, 11, pp.56-63. ⟨10.3998/ark.5550190.0008.b05⟩
ARKIVOC-Online Journal of Organic Chemistry, Arkat USA Inc, 2007, 11, pp.56-63. ⟨10.3998/ark.5550190.0008.b05⟩
ARKIVOC, Vol 2007, Iss 11, Pp 56-63 (2006)
ResearcherID
International audience; Pyridine cores 1a and 1b bearing thiazole rings feature in several natural products such as nosiheptide 2 and are often accessed through tedious synthetic routes. We have developed a new approach to the tetrasubstituted pyridi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3d14ac0347222f7a0fd18f06e15e43
http://www.scopus.com/inward/record.url?eid=2-s2.0-33846322546&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-33846322546&partnerID=MN8TOARS
