Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David Medovoy"'
Autor:
Yun Zhu, Zhao Chen, Kai Zhang, Mengchi Wang, David Medovoy, John W. Whitaker, Bo Ding, Nan Li, Lina Zheng, Wei Wang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The human genome is highly organized, with one-dimensional chromatin states packaged into higher level three-dimensional architecture. Here, the authors present EpiTensor that can identify 3D spatial associations from 1D epigenetic information.
Externí odkaz:
https://doaj.org/article/54d65bca25564014bcd842f0e9a3acf1
Autor:
David Medovoy, Wei Wang, Nan Li, Yun Zhu, Zhao Chen, Mengchi Wang, Lina Zheng, Bo Ding, John W. Whitaker, Kai Zhang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications
The human genome is tightly packaged into chromatin whose functional output depends on both one-dimensional (1D) local chromatin states and three-dimensional (3D) genome organization. Currently, chromatin modifications and 3D genome organization are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbe554eec56b508afebaa9a242551ed
https://doaj.org/article/54d65bca25564014bcd842f0e9a3acf1
https://doaj.org/article/54d65bca25564014bcd842f0e9a3acf1
Autor:
Qufei Li, Eduardo Perozo, Klaus Schulten, David Medovoy, Sherry Wanderling, Raymond E. Hulse, Anthony A. Kossiakoff, Carlos A. Villalba-Galea, Abhishek Singharoy, Ryan McGreevy, Benoît Roux, Marcin Paduch
Publikováno v:
Nature Structural & Molecular Biology. 21:244-252
The transduction of transmembrane electric fields into protein motion plays an essential role in the generation and propagation of cellular signals. Voltage-sensing domains (VSD) carry out these functions through reorientations of S4 helix with discr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53146d8e8a36f182eadde586370a8ec
https://doi.org/10.1038/nsmb.2768
https://doi.org/10.1038/nsmb.2768
Molecular Coupling in the Human ether-a-go-go-related gene-1 (hERG1) K+ Channel Inactivation Pathway
Autor:
Martin Tristani-Firouzi, Marcelo Arias, Julio F. Cordero-Morales, Eckhard Ficker, David Medovoy, Eduardo Perozo, Tania Ferrer
Publikováno v:
Journal of Biological Chemistry. 286:39091-39099
Emerging evidence suggests that K(+) channel inactivation involves coupling between residues in adjacent regions of the channel. Human ether-a-go-go-related gene-1 (hERG1) K(+) channels undergo a fast inactivation gating process that is crucial for m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffed3dcde13b79afb7219b26db0164e
https://doi.org/10.1074/jbc.m111.292060
https://doi.org/10.1074/jbc.m111.292060
Publikováno v:
Biochimica et biophysica acta. 1858(7 Pt)
Potassium (K(+)) channels are transmembrane proteins that passively and selectively allow K(+) ions to flow through them, after opening in response to an external stimulus. One of the most critical functional aspects of their function is their abilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0839d5616a3a2b3dfffc5f6c8bb16b1f
https://pubmed.ncbi.nlm.nih.gov/26896693
https://pubmed.ncbi.nlm.nih.gov/26896693
Computational Characterization of Conformational Transitions in the Voltage-Sensing Domain of Ci-VSP
Publikováno v:
Biophysical Journal. 110:106a
The canonical voltage-sensing domain (VSD) is a conserved structural module that transduces the electric field across cellular membranes into defined protein motions of its charge-rich helix, the S4 segment. Up on depolarization, the VSD rearranges f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb316f6a70c36705450c907e0628b23
https://doi.org/10.1016/j.bpj.2015.11.629
https://doi.org/10.1016/j.bpj.2015.11.629
Autor:
Walter Sandtner, Eduardo Perozo, Francisco Bezanilla, Ludivine Frezza, Olivier Dalmas, David Medovoy
Publikováno v:
Biophysical Journal. 106:448a
Magnesium (Mg(2+)) plays a central role in biology, regulating the activity of many enzymes and stabilizing the structure of key macromolecules. In bacteria, CorA is the primary source of Mg(2+) uptake and is self-regulated by intracellular Mg(2+). U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531abcb7d9f860f1c21e6c457dcd460c
https://doi.org/10.1016/j.bpj.2013.11.2540
https://doi.org/10.1016/j.bpj.2013.11.2540
Autor:
David Medovoy, Vishwanath Jogini, Valeria Vásquez, Julio F. Cordero-Morales, Eduardo Perozo, Martin Tristani-Firouzi, Anthony Lewis
Publikováno v:
Biophysical Journal. 100:426a
Mutations in human ether-a-go-go related K+ channel gene hERG1 are a common cause of Long QT syndrome (LQTS), an electrical disorder of the heart that predisposes individuals to sudden death. Of these, changes to the pore domain are associated with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc3e7a2d040d529b9b1997b93bc38ed
https://doi.org/10.1016/j.bpj.2010.12.2517
https://doi.org/10.1016/j.bpj.2010.12.2517
Publikováno v:
Biophysical Journal. (3):676a-677a
Potassium channels are tetrameric integral membrane proteins that passively allow rapid potassium conduction through the cell membrane while being strongly selective over other monovalent cations. A narrow region known as the selectivity filter, cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3182f796f5ef9372d57aba55893c05c8
Autor:
Dalmas, Olivier, Sandtner, Walter, Medovoy, David, Frezza, Ludivine, Bezanilla, Francisco, Perozo, Eduardo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 2/25/2014, Vol. 111 Issue 8, p3002-3007, 6p