Zobrazeno 1 - 10
of 38
pro vyhledávání: '"David McDougall"'
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 6, Pp n/a-n/a (2024)
Abstract The systemic exposure at the no‐observed‐adverse‐effect‐level (NOAEL) estimated from animals is an important criterion commonly applied to guard the safety of participants in clinical trials of investigational drugs. However, the dis
Externí odkaz:
https://doaj.org/article/58a999c5eead4fabaa55701bc86f924f
Akademický článek
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Autor:
John Jezorwski, Juan Jose Perez-Ruixo, Herta Crauwels, Carlos Perez-Ruixo, Oliver Ackaert, David McDougall
Publikováno v:
The AAPS Journal. 23
The single-tablet regimen darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg has undergone phase III studies AMBER (NCT02431247) and EMERALD (NCT02269917) in HIV-infected patients. An existing population pharmacoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe759544a84f9cc1b92aff565f41d3d
https://doi.org/10.1208/s12248-021-00607-8
https://doi.org/10.1208/s12248-021-00607-8
Autor:
Martin Coenen, Craig B. Langman, Bernd Hoppe, Michelle A. Baum, Kelly Barrios, David McDougall, Annelize Koch, Sander F. Garrelfs, Aniruddha Amrite, Jaap W. Groothoff, Graham Lipkin, Gesa Schalk, Pierre Cochat
Publikováno v:
Kidney international. Nature Publishing Group
Primary hyperoxaluria (PH) is a family of ultra-rare autosomal recessive inherited disorders of hepatic glyoxylate metabolism characterized by oxalate overproduction. Nedosiran is an RNA interference agent that inhibits hepatic lactate dehydrogenase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f77e773f290169ac0ad9c5fbd8d9ca
https://pure.amc.nl/en/publications/safety-pharmacodynamics-and-exposureresponse-modeling-results-from-a-firstinhuman-phase-1-study-of-nedosiran-phyox1-in-primary-hyperoxaluria(1c7005ba-03d0-46d6-9341-a3ec4ee99611).html
https://pure.amc.nl/en/publications/safety-pharmacodynamics-and-exposureresponse-modeling-results-from-a-firstinhuman-phase-1-study-of-nedosiran-phyox1-in-primary-hyperoxaluria(1c7005ba-03d0-46d6-9341-a3ec4ee99611).html
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
The subsurface of the highly productive Murzuq Basin in southwest Libya remains poorly understood. As a consequence, a need exists for detailed sedimentological studies of both the oil-prone Mamuniyat Formation and Hawaz Formation reservoirs in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd94460fdce220dcd07b0fc813f5453b
http://hdl.handle.net/2445/161896
http://hdl.handle.net/2445/161896
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 43:165-177
Model based personalised dosing (MBPD) is a sophisticated form of individualised therapy, where a population pharmacokinetic (PK) or pharmacodynamic model is utilised to estimate the dose required to reach a target exposure or effect. The choice of w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf37ed12344ae3e0ce479b04c80e36d
https://doi.org/10.1007/s10928-015-9462-9
https://doi.org/10.1007/s10928-015-9462-9
Publikováno v:
International Journal of Infectious Diseases, Vol 30, Iss C, Pp 161-165 (2015)
Summary Introduction Outpatient parenteral antibiotic therapy (OPAT) has become established as a standard of care in most Australian hospitals to treat a variety of infections. Since 1998, the Alternate Site Infusion Service (ASIS) has provided an OP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0ee341a818b6d001ec0985b11546b8
Autor:
Marjoree Sehu, Tina Patterson, Kate Houghton, B Pharm, Paul Firman, Zack Klyza, David McDougall
Publikováno v:
Open Forum Infectious Diseases
Background Community acquired pneumonia (CAP) is a common condition with significant morbidity and mortality especially in the elderly. Inappropriate selection of antibiotics has frequently been reported in the literature, including within the Austra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0a30a4d45419accaa847580d52f7b0
https://doi.org/10.1093/ofid/ofy210.1500
https://doi.org/10.1093/ofid/ofy210.1500
Autor:
Nicholas G. H. Mohtadi, John Grant, Richard E. A. Walker, Shamir Patel, Peter David Longino, David McDougall
Publikováno v:
American Journal of Roentgenology. 201:483-495
This imaging-based article systematically reviews traumatic knee dislocations. After completion, the reader should be familiar with the definition, epidemiology, cause, and classification schemes associated with these injuries, as well as the importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55087f3f066be9508f03fb3649ccebbd
https://doi.org/10.2214/ajr.12.10221
https://doi.org/10.2214/ajr.12.10221