Zobrazeno 1 - 10
of 13
pro vyhledávání: '"David Mark Pritchard"'
Autor:
Thomas Edward Conley, Rachael Slater, Stephen Moss, David Colin Bulmer, Juan de la Revilla Negro, Umer Zeeshan Ijaz, David Mark Pritchard, Miles Parkes, Chris Probert
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105282- (2024)
Summary: Background: Irritable bowel syndrome (IBS) is a common and debilitating disorder manifesting with abdominal pain and bowel dysfunction. A mainstay of treatment is dietary modification, including restriction of FODMAPs (fermentable oligosacch
Externí odkaz:
https://doaj.org/article/f8af627437b94096a8628c27e6cd1ad5
Publikováno v:
Cell Death and Disease, Vol 14, Iss 4, Pp 1-11 (2023)
Abstract Galectin-3 is a galactoside-binding protein that is commonly overexpressed in many epithelial cancers. It is increasingly recognized as a multi-functional, multi-mode promoter in cancer development, progression, and metastasis. This study re
Externí odkaz:
https://doaj.org/article/5b06190b06684cf7be425e0d44fd1674
Autor:
Louis Gall, Carrie Duckworth, Ferran Jardi, Lieve Lammens, Aimee Parker, Ambra Bianco, Holly Kimko, David Mark Pritchard, Carmen Pin
Publikováno v:
eLife, Vol 12 (2023)
The maintenance of the functional integrity of the intestinal epithelium requires a tight coordination between cell production, migration, and shedding along the crypt–villus axis. Dysregulation of these processes may result in loss of the intestin
Externí odkaz:
https://doaj.org/article/018bbe6213294175aa395f530f4a00b7
Autor:
Lu-Gang Yu, Jonathan M. Rhodes, David Mark Pritchard, Qicheng Zhao, Carrie A. Duckworth, Chen Chen
Purpose: Cytokines such as interleukin (IL)-6 and granulocyte colony-stimulating factor (G-CSF) are important metastasis promoters. This study has investigated the functional significance of the increased circulation of galectin-3, a common feature i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d7ca41949fe6b05b99716ccc3cb3a1
https://doi.org/10.1158/1078-0432.c.6523268
https://doi.org/10.1158/1078-0432.c.6523268
Autor:
Lu-Gang Yu, Jonathan M. Rhodes, David Mark Pritchard, Qicheng Zhao, Carrie A. Duckworth, Chen Chen
PDF file - 106K, Table S1: Characteristics of the colorectal cancer patients; Fig S1: Effect of low and high galectin-3-containing human serum on cytokine secretion from HMVECs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00408abce31ac127a070d5bbe415fae4
https://doi.org/10.1158/1078-0432.22456298.v1
https://doi.org/10.1158/1078-0432.22456298.v1
Publikováno v:
CANCERS
Matrix metalloproteinase-13 (MMP-13) is a member of the Matrix metalloproteinases (MMPs) family of endopeptidases. MMP-13 is produced in low amounts and is well-regulated during normal physiological conditions. Its expression and secretion are, howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b5bbcc66bfa43d9808f85070a14154
https://pubmed.ncbi.nlm.nih.gov/35805035
https://pubmed.ncbi.nlm.nih.gov/35805035
Autor:
Edward, Alabraba, David Mark, Pritchard, Rebecca, Griffin, Rafael, Diaz-Nieto, Melissa, Banks, Daniel James, Cuthbertson, Stephen, Fenwick
Publikováno v:
Endocrine. 73(3)
Appendiceal goblet cell carcinomas (aGCCs) are rare but aggressive tumours associated with significant mortality. We retrospectively reviewed the outcomes of aGCC patients treated at our tertiary referral centre.We analysed aGCC patients, diagnosed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ad82db405b841fbcf5f88bd5e9fb999
https://pubmed.ncbi.nlm.nih.gov/33891259
https://pubmed.ncbi.nlm.nih.gov/33891259
Publikováno v:
Europe PubMed Central
The thymidylate synthase inhibitor raltitrexed (ZD1694, Tomudex) induces greater intestinal toxicity, manifested as diarrhea and weight loss, in BALB/c than in DBA/2 mice. No convincing pharmacokinetic or pharmacodynamic reason for this strain differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5cc600ce156b32dec47e6bb1db4384b2
https://pubmed.ncbi.nlm.nih.gov/11106258
https://pubmed.ncbi.nlm.nih.gov/11106258
Publikováno v:
Europe PubMed Central
The relationship between acute (36 h) induction of apoptosis and longer-term (72 h) intestinal histopathology was systematically investigated in vivo using p53 wild-type (+/+) and null (-/-) mice. Administration of the enterotoxin 5-fluorouracil (5-F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::82e2ccb9460374cdb05631dfe2a311b1
https://pubmed.ncbi.nlm.nih.gov/9850079
https://pubmed.ncbi.nlm.nih.gov/9850079
Autor:
Fitzgerald, R. C., Abdalla, S., Haigh, C. R., Kirton, C. M., David Mark Pritchard, Varro, A., Dimaline, R., Attwood, S. E. A., Thompson, D. G., Jankowski, J. A.
Publikováno v:
Scopus-Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0ed02004ef6ed718e70c1130187e1088
http://www.scopus.com/inward/record.url?eid=2-s2.0-10744225728&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-10744225728&partnerID=MN8TOARS