Zobrazeno 1 - 10
of 95
pro vyhledávání: '"David Margulies"'
Autor:
Jonathan Yaacov Weinstein, Carlos Martí-Gómez, Rosalie Lipsh-Sokolik, Shlomo Yakir Hoch, Demian Liebermann, Reinat Nevo, Haim Weissman, Ekaterina Petrovich-Kopitman, David Margulies, Dmitry Ivankov, David M. McCandlish, Sarel J. Fleishman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Mutations in a protein active site can lead to dramatic and useful changes in protein activity. The active site, however, is sensitive to mutations due to a high density of molecular interactions, substantially reducing the likelihood of obt
Externí odkaz:
https://doaj.org/article/0a700fa200fc4fecb09ddd2b73e61207
Autor:
Luis A. Williams, David J. Gerber, Amy Elder, Wei Chou Tseng, Valeriya Baru, Nathaniel Delaney-Busch, Christina Ambrosi, Gauri Mahimkar, Vaibhav Joshi, Himali Shah, Karthiayani Harikrishnan, Hansini Upadhyay, Sakthi H. Rajendran, Aishwarya Dhandapani, Joshua Meier, Steven J. Ryan, Caitlin Lewarch, Lauren Black, Julie Douville, Stefania Cinquino, Helen Legakis, Karsten Nalbach, Christian Behrends, Ai Sato, Lorenzo Galluzzi, Timothy W. Yu, Duncan Brown, Sudhir Agrawal, David Margulies, Alan Kopin, Graham T. Dempsey
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 189-203 (2022)
Mutations in the TECPR2 gene are the cause of an ultra-rare neurological disorder characterized by intellectual disability, impaired speech, motor delay, and hypotonia evolving to spasticity, central sleep apnea, and premature death (SPG49 or HSAN9;
Externí odkaz:
https://doaj.org/article/555fd4156baf47509e8e7211947eb238
Autor:
Pragati K. Prasad, Noa Eizenshtadt, Inna Goliand, Liat Fellus-Alyagor, Roni Oren, Ofra Golani, Leila Motiei, David Margulies
Publikováno v:
Materials Today Bio, Vol 20, Iss , Pp 100669- (2023)
Common methods to label cell surface proteins (CSPs) involve the use of fluorescently modified antibodies (Abs) or small-molecule-based ligands. However, optimizing the labeling efficiency of such systems, for example, by modifying them with addition
Externí odkaz:
https://doaj.org/article/3b84f0dd00f44e488e75b0b7e3076828
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2749-2756 (2020)
A method for encrypting messages using engineered bacteria and different fluorescently labeled synthetic receptors is described. We show that the binding of DNA-based artificial receptors to E. coli expressing His-tagged outer membrane protein C (His
Externí odkaz:
https://doaj.org/article/a7f7ecc0a65b4810b0f4a355bd439a06
Autor:
Naama Lahav-Mankovski, Pragati Kishore Prasad, Noa Oppenheimer-Low, Gal Raviv, Tali Dadosh, Tamar Unger, Tomer Meir Salame, Leila Motiei, David Margulies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cell surface proteins mediate the interactions between cells and their extracellular environment. Here the authors design synthetic biomemetic receptor-like sensors that facilitate programmable interactions between bacteria and their target.
Externí odkaz:
https://doaj.org/article/1775545b224b434386e60ac5594acff8
Publikováno v:
Results in Chemistry, Vol 3, Iss , Pp 100134- (2021)
Labeling of proteins with small-molecule-based fluorescent probes provides a powerful tool to determine their expression level and localization in living cells. We propose a method for increasing and stabilizing the emission of such probes using supr
Externí odkaz:
https://doaj.org/article/55feab2dd5464a87a6f95396556222ba
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
An emerging direction in the area of molecular logic and computation is developing molecular-scale devices that can operate in complex biological environments, such as within living cells, which are beyond the reach of conventional electronic devices
Externí odkaz:
https://doaj.org/article/20d2ad7145ed4a198f740dfa69f7c61d
Publikováno v:
Molecules, Vol 26, Iss 9, p 2828 (2021)
Fluorescent sensing of biomolecules has served as a revolutionary tool for studying and better understanding various biological systems. Therefore, it has become increasingly important to identify fluorescent building blocks that can be easily conver
Externí odkaz:
https://doaj.org/article/8281c792545a45589688fb0a4a4ce1b7
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Although historically common chemicals were frequently used as secret inks, the ease of readout could not prevent unauthorized reading. Here, the authors report a multi-analyte sensor that can conceal and encrypt messages by responding to simple chem
Externí odkaz:
https://doaj.org/article/75c087c4b1814f4f8da1ae5203ba0b80
Publikováno v:
Proceedings, Vol 1, Iss 8, p 720 (2017)
The self-assembly of amyloid beta (Aβ) peptides into insoluble aggregates is thought to play a [...]
Externí odkaz:
https://doaj.org/article/75fa7cf456b24cbdad2d08ca3eb1f834