Generation of human parallel chimeric antigen receptor (pCAR) T cells to achieve synergistic T cell co-stimulation

Autor: Daniel Larcombe-Young, Lynsey Whilding, David Marc Davies, Benjamin Draper, Natasha Bechman, John Maher

Publikováno v: Larcombe-Young, D, Whilding, L, Davies, D, Draper, B, Bechman, N & Maher, J 2022, ' Generation of human parallel chimeric antigen receptor (pCAR) T cells to achieve synergistic T cell co-stimulation ', STAR Protocols, vol. 3, no. 2, 101414 . https://doi.org/10.1016/j.xpro.2022.101414

Dual co-stimulation may be harnessed using parallel chimeric antigen receptors(pCARs) in which two distinct co-stimulatory units are adjacently localized onthe plasma membrane. This protocol summarizes construct design, human Tcell isolation, retrovi

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https://kclpure.kcl.ac.uk/ws/files/175763017/Generation_of_human_parallel_LARCOMBE_YOUNG_Publishedonline27May2022_GOLD_VoR_CC_BY.pdf