Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David Maraldo"'
Autor:
David Maraldo, Raj Mutharasan
Publikováno v:
Sensors and Actuators B: Chemical. 143:731-739
We show that mass-change sensitivity predicted from first principles model of piezoelectric-excited millimeter-sized cantilever (PEMC) sensors is in reasonable agreement with previously reported experimental values. We introduce a new attogram-level
Autor:
David Maraldo, Raj Mutharasan
Publikováno v:
Sensors and Actuators B: Chemical. 132:140-148
We show for the first time that approximate analytical models do not predict mass-change sensitivity of cantilever sensors of non-uniform cross-section. On the other hand, finite element model (FEM) is a better approach for determining the performanc
Autor:
Raj Mutharasan, David Maraldo
Publikováno v:
Sensors and Actuators B: Chemical. 123:474-479
The effectiveness of antibody immobilization on sensor performance was evaluated using a piezoelectric-excited millimeter-sized cantilever (PEMC) sensor and a model protein, bovine serum albumin (BSA). The immobilization parameters—antibody and act
Publikováno v:
Analytical Chemistry. 79:2762-2770
Rapid (approximately 10 min) measurement of very low concentration of pathogens (approximately 10 cells/mL) and protein (approximately fg/mL) has widespread use in medical diagnostics, monitoring biothreat agents, and in a broader context as a resear
Autor:
Jose Manuel Otero, Andrew Franklin, Elizabeth Sullivan, David Maraldo, Roberto Ortiz, Mark Mikola, Matthew Houser, Jennifer Haas
Publikováno v:
Vaccine. 32(24)
This case study provides an example of how Quality by Design (QbD) principles were applied to accelerate process development to manufacture a vaccine candidate at commercial scale. By leveraging an existing manufacturing platform process, a risk asse
Autor:
Raj Mutharasan, David Maraldo
Publikováno v:
Analytical chemistry. 79(20)
A sensitive and reliable method for the detection of a model toxin, staphylococcal enterotoxin B (SEB) in buffer, apple juice, and milk is shown using piezoelectric-excited, millimeter-sized cantilever (PEMC) sensors. Limit of detection in spiked mil
Publikováno v:
Analytical chemistry. 79(20)
We describe a macrocantilever-based method for detecting a prostate cancer biomarker (alpha-methylacyl-CoA racemase; AMACR) directly in patient urine without a sample preparation step and without the use of labeled reagents. Clean catch voided urine
Autor:
David Maraldo, Raj Mutharasan
Publikováno v:
Journal of food protection. 70(7)
We detected Escherichia coli O157:H7 (EC) at approximately 10 cells per ml in spiked ground beef samples in 10 min using piezoelectric-excited millimeter-size cantilever (PEMC) sensors. The composite PEMC sensors have a sensing area of 2 mm2 and are
Autor:
R. Nagarajan, Walter Zukas, T. Alan Hatton, Stephen Lee, Charles A. Bass, Catherine Cabrera, James Harper, Roderick Kunz, Theodore Lyszczarz, Lalitha Parameswaran, Mordechai Rothschild, Michael Sennett, Michael Switkes, Hema Viswanath, Gossett Campbell, David Maraldo, Raj Mutharasan, Minoo Naebe, Tong Lin, Lianfang Feng, Liming Dai, Alexis Abramson, Vikas Prakash, Xungia Wang, Pornnipa Vichchulada, Deepa Vairavapandian, Marcus D. Lay, Letha J. Sooter, Dimitra N. Stratis-Cullum, Yanting Zhang, Jeffrey J. Rice, John T. Ballew, Hyongsok T. Soh, Patrick S. Daugherty, Paul Pellegrino, Nancy Stagliano, Yuehe Lin, Jun Wang, Guodong Liu, Charles Timchalk, J. D. Driskell, S. Shanmukh, Y. Liu, S. Chaney, S. Hennigan, L. Jones, D. Krause, R. A. Tripp, Y.-P. Zhao, R. A. Dluhy, Paresh Chandra Ray, Gopala Krishna Darbha, Oleg Tovmachenko, Uma Shanker Rai, Jelani Griffin, William Hardy, Ana Balarezo, Michael L. Ramirez, Leonardo C. Pacheco, Marcos A. Barreto, Samuel P. Hernández-Rivera, Amy Szuchmacher Blum, Carissa M. Soto, Gary J. Vora, Kim E. Sapsford, Banahall