Zobrazeno 1 - 10
of 398
pro vyhledávání: '"David Malka"'
Autor:
Julieta E. Rodriguez, Damien Vasseur, Mohamed Amine Bani, Odile Cabaret, Sophie Cotteret, Martine Muleris, Veronica Golbarg, David Malka, Thomas Pudlarz, Olivier Caron, Cristina Smolenschi
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionMicrosatellite instability (MSI) is a genetic marker that is useful in the detection and treatment of Lynch syndrome (Sd). Although conventional techniques such as immunohistochemistry (IHC) and polymerase chain reaction (PCR) are the sta
Externí odkaz:
https://doaj.org/article/54fec50bb2b942a79241dc0f02c735e2
Autor:
Jérôme Cartry, Sabrina Bedja, Alice Boilève, Jacques R. R. Mathieu, Emilie Gontran, Maxime Annereau, Bastien Job, Ali Mouawia, Pierre Mathias, Thierry De Baère, Antoine Italiano, Benjamin Besse, Isabelle Sourrouille, Maximiliano Gelli, Mohamed-Amine Bani, Peggy Dartigues, Antoine Hollebecque, Cristina Smolenschi, Michel Ducreux, David Malka, Fanny Jaulin
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background Patient Derived Organoids (PDOs) emerged as the best technology to develop ex vivo tumor avatars. Whether drug testing on PDOs to identify efficient therapies will bring clinical utility by improving patient survival remains uncle
Externí odkaz:
https://doaj.org/article/0d8a07fdb2e64fafb7f7082f91aca715
Autor:
Jean-Louis Legoux, Roger Faroux, Nicolas Barrière, Karine Le Malicot, David Tougeron, Véronique Lorgis, Véronique Guerin-Meyer, Vincent Bourgeois, David Malka, Thomas Aparicio, Matthieu Baconnier, Valérie Lebrun-Ly, Joëlle Egreteau, Faïza Khemissa Akouz, Magali Terme, Côme Lepage, Valérie Boige
Publikováno v:
Cancers, Vol 16, Iss 8, p 1515 (2024)
Fluropyrimidine monotherapy is an option for some patients with inoperable metastatic colorectal cancer. Unlike bevacizumab, the addition of aflibercept, an antibody acting as an anti-angiogenic agent, has never been evaluated in this context. The ai
Externí odkaz:
https://doaj.org/article/40c4d0c2d4ac4f6f983b13dc163f3d4c
Autor:
Anthony Tarabay, Alice Boileve, Cristina Smolenschi, Leony Antoun, Marine Valery, Alina Fuerea, Audrey Perret, Pascal Burtin, Simona Cosconea, Hichem Belkhodja, David Malka, Valérie Boige, Antoine Hollebecque, Michel Ducreux
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2569 (2023)
Background: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of death by cancer worldwide. Mostly diagnosed with locally advanced or metastatic disease, patients lack treatment options. Gene alterations (GAs) are frequently observed
Externí odkaz:
https://doaj.org/article/26a3fb018c8542f2bb1c09dce554c516
Autor:
Eugénie Rigault, Benjamin Lacas, Olivier Glehen, Denis Smith, Eric Dupont-Bierre, Rosine Guimbaud, David Malka, Valérie Boige, Alina Fuerea, Jean-Pierre Pignon, Michel Ducreux
Publikováno v:
Cancer Treatment and Research Communications, Vol 34, Iss , Pp 100674- (2023)
Introduction: Intra-arterial hepatic (IAH) treatment has shown promising results in the management of patients with unresectable colorectal liver metastases (CRLM) the prognosis of which is poor. Bevacizumab adjunction to standard chemotherapy has be
Externí odkaz:
https://doaj.org/article/c22bcb3444d34782a25dee5d64cfa6c8
Autor:
David Malka, Philippe Laramée, Mondher Toumi, Jean-Baptiste Trouiller, Bérengère Macabeo, Andrew Poll, Dan Howard, Andy Buckland, Marine Sivignon, Emilie Clay, Emmanuelle Samalin
Publikováno v:
BMJ Open, Vol 12, Iss 11 (2022)
Objective The BEACON CRC randomised controlled trial (NCT02928224) in BRAF-mutant metastatic colorectal cancer (mCRC) patients showed improved overall survival for the combination treatment of encorafenib (BRAF inhibitor) with cetuximab (EGFR inhibit
Externí odkaz:
https://doaj.org/article/223f47e391ee4605ad9203dec8cf7868
Publikováno v:
European Medical Journal Oncology, Vol 8, Iss 1, Pp 82-94 (2020)
Cholangiocarcinomas (CCA) are uncommon malignant tumours and are classified as intrahepatic, perihilar, or distal, depending on where they arise within the biliary epithelium. Surgery is still the only curative treatment, yet diagnosis is often made
Externí odkaz:
https://doaj.org/article/370569a8858447c5914ccada9ac123cf
Autor:
Ruth Gabriela Herrera-Gómez, Miruna Grecea, Claire Gallois, Valérie Boige, Patricia Pautier, Barbara Pistilli, David Planchard, David Malka, Michel Ducreux, Olivier Mir
Publikováno v:
Cancers, Vol 14, Iss 12, p 2914 (2022)
Background: The safety of bevacizumab in combination with chemotherapy in patients with inflammatory bowel disease (IBD) and digestive and nondigestive cancers is poorly documented. Methods: We retrospectively evaluated patient records of all adult c
Externí odkaz:
https://doaj.org/article/e75464e13e6b4f9e969e83585288d70b
Autor:
Diane Goéré, Jean-Pierre Pignon, Maximiliano Gelli, Dominique Elias, Léonor Benhaim, Frédéric Deschamps, Caroline Caramella, Valérie Boige, Michel Ducreux, Thierry de Baere, David Malka
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background After curative-intent surgery for colorectal liver metastases (CRLM), liver recurrence occurs in more than 60% of patients, despite the administration of perioperative or adjuvant chemotherapy. This risk is even higher after resec
Externí odkaz:
https://doaj.org/article/d8fe7864dd004117aa4d7b9f2afc6de7
Autor:
Juliette Palle, Laure Hirsch, Alexandra Lapeyre-Prost, David Malka, Morgane Bourhis, Simon Pernot, Elie Marcheteau, Thibault Voron, Florence Castan, Ariane Lacotte, Nadine Benhamouda, Corinne Tanchot, Eric François, François Ghiringhelli, Christelle de la Fouchardière, Aziz Zaanan, Eric Tartour, Julien Taieb, Magali Terme
Publikováno v:
Cancers, Vol 13, Iss 21, p 5562 (2021)
Elucidating mechanisms involved in tumor-induced immunosuppression is of great interest since it could help to improve cancer immunotherapy efficacy. Here we show that Hepatocyte Growth Factor (HGF), a pro-tumoral and proangiogenic factor, and its re
Externí odkaz:
https://doaj.org/article/c25ad10896804800b263589545bd4b25