Zobrazeno 1 - 10
of 35
pro vyhledávání: '"David MacTavish"'
Autor:
Wen Fu, Vlatka Vukojevic, Aarti Patel, Rania Soudy, David MacTavish, David Westaway, Kamaljit Kaur, Valeri Goncharuk, Jack Jhamandas
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-12 (2017)
Abstract Background Neuroinflammation in the brain consequent to activation of microglia is viewed as an important component of Alzheimer’s disease (AD) pathology. Amyloid beta (Aβ) protein is known to activate microglia and unleash an inflammator
Externí odkaz:
https://doaj.org/article/9a9fa02c523c4fa99cf9b49d41312e22
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 2, Pp 413-420 (2006)
In brains of Alzheimer's disease (AD) patients, expression of the neuropeptide galanin is significantly upregulated and galanin-immunoreactive fibers hypertrophy and hyperinnervate cholinergic neurons of the basal forebrain. However, the role of gala
Externí odkaz:
https://doaj.org/article/47a673c8f781415da9bb5556c8cd704a
Autor:
Wen Fu, Jack H. Jhamandas, Rania Soudy, Rachel A Davey, Jing Yang, Ryoichi Kimura, Jeffrey D Zajac, Aarti Patel, David Westaway, David MacTavish
Publikováno v:
Molecular Neurobiology
Based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a class B G protein-coupled receptor (GPCR), is a potential modulator of Alzheimer’s disease (AD) pathogenesis. However, past pharmacological approaches have failed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6440906649361b0bae4fb8ede6397c
https://doi.org/10.21203/rs.3.rs-515476/v1
https://doi.org/10.21203/rs.3.rs-515476/v1
Autor:
Aarti Patel, Wen Fu, Jack H. Jhamandas, David MacTavish, Rania Soudy, Rachel A Davey, David Westaway, Kamaljit Kaur, Jeffrey D Zajac
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction Amylin receptor serves as a portal for the expression of deleterious effects of amyloid β-protein (Aβ), a key pathologic hallmark of Alzheimer's disease. Previously, we showed that AC253, an amylin receptor antagonist, is neuroprotecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d793f7ab482703bfeb1a50a3abb369
https://doi.org/10.1016/j.trci.2016.11.005
https://doi.org/10.1016/j.trci.2016.11.005
Publikováno v:
Molecular Neurobiology. 54:748-754
Accumulation of amyloid-β peptide (Aβ) is a pathological hallmark of Alzheimer’s disease (AD). We have previously demonstrated that electrophysiological and neurotoxic effects of Aβ and human amylin are expressed via the amylin receptor. Recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5838e8ecdf40c69983e359606414a760
https://doi.org/10.1007/s12035-016-9684-x
https://doi.org/10.1007/s12035-016-9684-x
Autor:
Richard P. Fahlman, Aarti Patel, Wen Fu, Jack H. Jhamandas, Vishnu Vasanthan, David MacTavish
Publikováno v:
Brain Structure and Function. 221:1845-1860
Accumulation of β-amyloid (Aβ) protein within the brain is a neuropathological hallmark of Alzheimer's disease (AD). One strategy to facilitate Aβ clearance from the brain is to promote Aβ catabolism. Matrix metalloproteinase-9 (MMP-9), a member
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f51c1a26567eab608d1e3cb7b2151bf
https://doi.org/10.1007/s00429-015-1007-x
https://doi.org/10.1007/s00429-015-1007-x
Autor:
Jack H. Jhamandas, Vlatka Vukojevic, Aarti Patel, David MacTavish, Rania Soudy, Kamaljit Kaur, Wen Fu, David Westaway, Valeri D. Goncharuk
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-12 (2017)
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-12 (2017)
Background Neuroinflammation in the brain consequent to activation of microglia is viewed as an important component of Alzheimer’s disease (AD) pathology. Amyloid beta (Aβ) protein is known to activate microglia and unleash an inflammatory cascade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d94af526aecf38d4b62baf35f254ee
http://europepmc.org/articles/PMC5639602
http://europepmc.org/articles/PMC5639602
Autor:
Klaus Ballanyi, Wen Fu, David MacTavish, Araya Ruangkittisakul, Glen B. Baker, Jack H. Jhamandas
Publikováno v:
Neuroscience. 250:520-535
Neurons and neighboring astrocytic glia are mostly studied in nervous tissues from rodents whereas less is known on their properties and interactions in the human brain. Here, confocal/multiphoton fluorescence imaging for several hours revealed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a8dd818329b03fccb75658554985a6
https://doi.org/10.1016/j.neuroscience.2013.07.029
https://doi.org/10.1016/j.neuroscience.2013.07.029
Autor:
Jack H. Jhamandas, David MacTavish
Publikováno v:
Apoptosis. 17:37-47
Deposition of amyloid-beta (Aβ) protein, a 39-43 amino acid peptide, in the brain is a major pathological feature of Alzheimer's disease (AD). We have previously provided evidence that in primary cultures of rat basal forebrain and human fetal neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50c958ed66e5279c68b8ceeb98efa12
https://doi.org/10.1007/s10495-011-0656-3
https://doi.org/10.1007/s10495-011-0656-3
Publikováno v:
The Journal of Neuroscience. 27:9262-9269
Amyloid β (Aβ) protein, a 39–43 amino acid peptide deposited in brains of individuals with Alzheimer's disease (AD), has been shown to interact directly with a number of receptor targets including neuronal nicotinic acetylcholine receptors (nAChR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620a72452a0370a8c1da9e99a8989047
https://doi.org/10.1523/jneurosci.1843-07.2007
https://doi.org/10.1523/jneurosci.1843-07.2007