Zobrazeno 1 - 10
of 205
pro vyhledávání: '"David M. de Kretser"'
Autor:
Alice M. Richardson, Don P. Lewis, Badia Kita, Helen Ludlow, Nigel P. Groome, Mark P. Hedger, David M. de Kretser, Brett A. Lidbury
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-11 (2018)
Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is clinically defined and characterised by persistent disabling tiredness and exertional malaise, leading to functional impairment. Methods This study introduces the weig
Externí odkaz:
https://doaj.org/article/9dbed92699a8462fbc64bdd76cdf4ca2
Publikováno v:
Reproductive Sciences. 28:2916-2928
Cryptorchidism causes spermatogenic failure and reduced serum androgen levels, as well as testicular oedema and fibrosis, which are hallmarks of inflammation. However, the role of inflammation and the effects of cryptorchidism on Sertoli cell and Ley
Autor:
Shane M Colley, Larissa Wintle, Richelle Searles, Victoria Russell, Renee C Firman, Stephanie Smith, Kathleen Deboer, D Jo Merriner, Ben Genevieve, Jacqueline M Bentel, Bronwyn G A Stuckey, Michael R Phillips, Leigh W Simmons, David M de Kretser, Moira K O'Bryan, Peter J Leedman
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70700 (2013)
Nuclear receptors (NRs) and their coregulators play fundamental roles in initiating and directing gene expression influencing mammalian reproduction, development and metabolism. SRA stem Loop Interacting RNA-binding Protein (SLIRP) is a Steroid recep
Externí odkaz:
https://doaj.org/article/7f91d76418a14cfc994b9db99320d800
Autor:
Peter Temple-Smith, Seungmin Ham, Craig A. Harrison, Graeme Southwick, David M. de Kretser, Euan M. Wallace
Publikováno v:
Experimental dermatologyREFERENCES. 30(3)
Keloids are benign tumours caused by abnormal wound healing driven by increased expression of cytokines, including activin A. This study compared effects of activins on normal and keloid-derived human dermal fibroblasts and investigated a novel treat
Publikováno v:
Reproductive sciences (Thousand Oaks, Calif.). 28(10)
Cryptorchidism causes spermatogenic failure and reduced serum androgen levels, as well as testicular oedema and fibrosis, which are hallmarks of inflammation. However, the role of inflammation and the effects of cryptorchidism on Sertoli cell and Ley
Autor:
David M. de Kretser, Rukmali Wijayarathna, Kate A. Loveland, Helen Ludlow, Andreas Meinhardt, Ralf Middendorff, Nigel P. Groome, Mark P. Hedger
Publikováno v:
Molecular and Cellular Endocrinology. 470:188-198
Regionalised interaction of the activins, follistatin and inhibin was investigated in the male reproductive tract of mice lacking the inhibin α-subunit (Inha-/-). Serum and intratesticular activin B, although not activin A and follistatin, were incr
Autor:
Constanze Christin Maresch, Dina C. Stute, Pedro Oliveira, Marco G. Alves, David M. de Kretser, Thomas Linn
Publikováno v:
Human Reproduction Update. 24:86-105
Background Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in their function leading to decreased insulin secretion or may arise from insulin resistance and variable degrees of inadequate insulin secretion resulting in diab
Autor:
Helen Ludlow, Constanze C. Maresch, Dina C. Stute, Thomas Linn, David M. de Kretser, Hans-Peter Hammes, Mark P. Hedger
Publikováno v:
Molecular and Cellular Endocrinology. 446:91-101
Type 1 diabetes (T1D) is associated with subfertility in men. We hypothesised that this results from inhibitory effects of chronic hyperglycemia on testicular function and used the Ins2Akita+/- mouse model to investigate this. Diabetic mice exhibited
Autor:
Mark P. Hedger, Susan Hayward, Brett A. Lidbury, David M. de Kretser, Badia Kita, Donald P. Lewis, Alice Richardson, Edwina Privitera
Publikováno v:
Diagnostics, Vol 9, Iss 3, p 79 (2019)
Diagnostics
Volume 9
Issue 3
Diagnostics
Volume 9
Issue 3
Biomarker discovery applied to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disabling disease of inconclusive aetiology, has identified several cytokines to potentially fulfil a role as a quantitative blood/serum marker for laborato
Publikováno v:
Molecular and cellular endocrinology. 498
Heat reversibly disrupts spermatogenesis, but the effects on Sertoli cell (SC) function and inhibin/activin-related proteins are less well-defined. Adult rat testis weights decreased by 40% within 2 weeks after heat-treatment (43 °C, 15 min), due to