Zobrazeno 1 - 10
of 50
pro vyhledávání: '"David M. Zhang"'
Autor:
David M. Zhang, Rachita Navara, Tiankai Yin, Jeffrey Szymanski, Uri Goldsztejn, Camryn Kenkel, Adam Lang, Cedric Mpoy, Catherine E. Lipovsky, Yun Qiao, Stephanie Hicks, Gang Li, Kaitlin M. S. Moore, Carmen Bergom, Buck E. Rogers, Clifford G. Robinson, Phillip S. Cuculich, Julie K. Schwarz, Stacey L. Rentschler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac con
Externí odkaz:
https://doaj.org/article/b87d769fbd7248d484a32dad47327e5a
Autor:
Catherine E. Lipovsky, Jesus Jimenez, Qiusha Guo, Gang Li, Tiankai Yin, Stephanie C. Hicks, Somya Bhatnagar, Kentaro Takahashi, David M. Zhang, Brittany D. Brumback, Uri Goldsztejn, Rangarajan D. Nadadur, Carlos Perez-Cervantez, Ivan P. Moskowitz, Shaopeng Liu, Bo Zhang, Stacey L. Rentschler
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Atrial fibrillation (AF) is the most common cardiac arrhythmia, yet the molecular signature of the vulnerable atrial substrate is not well understood. Here, we delineated a distinct transcriptional signature in right versus left atrial cardiomyocytes
Externí odkaz:
https://doaj.org/article/47324dd7c833416f9a9884ad95536924
Autor:
Gang Li, Brittany D. Brumback, Lei Huang, David M. Zhang, Tiankai Yin, Catherine E. Lipovsky, Stephanie C. Hicks, Jesus Jimenez, Patrick M. Boyle, Stacey L. Rentschler
Publikováno v:
JACC: Basic to Translational Science. 7:1001-1017
Glycogen synthase kinase 3 (GSK-3) inhibition has emerged as a potential therapeutic target for several diseases, including cancer. However, the role for GSK-3 regulation of human cardiac electrophysiology remains ill-defined. We demonstrate that SB2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce118c424bf89ebef749f059b7d3056
https://doi.org/10.1016/j.jacbts.2022.04.007
https://doi.org/10.1016/j.jacbts.2022.04.007
Autor:
Brittany D. Brumback, Oleksandr Dmytrenko, Ashley N. Robinson, Adam L. Bailey, Pan Ma, Jing Liu, Stephanie C. Hicks, Sherwin Ng, Gang Li, David M. Zhang, Catherine E. Lipovsky, Chieh-Yu Lin, Michael S. Diamond, Kory J. Lavine, Stacey L. Rentschler
Publikováno v:
JACC. Basic to translational science.
Coronavirus disease 2019 (COVID-19) is associated with serious cardiovascular complications, with incompletely understood mechanism(s). Pericytes have key functions in supporting endothelial cells and maintaining vascular integrity. We demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d2489bfb8a2c1e72c27366e879b309
https://pubmed.ncbi.nlm.nih.gov/36124009
https://pubmed.ncbi.nlm.nih.gov/36124009
Autor:
Cedric Mpoy, Carmen Bergom, Clifford G. Robinson, Julie K. Schwarz, David M. Zhang, Catherine E. Lipovsky, Buck E. Rogers, Tiankai Yin, Camryn Kenkel, Uri Goldsztejn, Phillip S. Cuculich, K.M.S. Moore, Jeffrey J. Szymanski, Stacey Rentschler, Stephanie C. Hicks, Gang Li, Rachita Navara, Adam Lang, Yun Qiao
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Cardiac radiotherapy (RT) may be effective in treating heart failure (HF) patients with refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation-induced fibrosis does not explain the rapidity and magnitude with which VT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8371b63539f3179e8a0538c89f2551
https://doi.org/10.1038/s41467-021-25730-0
https://doi.org/10.1038/s41467-021-25730-0
Autor:
Erica C. Pehrsson, Xiaoyun Xing, Zea Z. Dailey, David M. Zhang, Daofeng Li, Sungsu Kim, David O'Donnell, Ting Wang, Paula M. Godoy, Hyo Sik Jang, Nakul M. Shah, Jeffrey I. Gordon, Alan Y. Du
Publikováno v:
Nature genetics
Transposable elements (TEs) are an abundant and rich genetic resource of regulatory sequences1–3. Cryptic regulatory elements within TEs can be epigenetically reactivated in cancer to influence oncogenesis in a process termed onco-exaptation4. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fa3bf9c6b0d70f735714794cbe2240
https://doi.org/10.1038/s41588-019-0373-3
https://doi.org/10.1038/s41588-019-0373-3
Autor:
Jeffrey J. Szymanski, Cliff G. Robinson, Carmen Bergom, Phillip S. Cuculich, Julie K. Schwarz, Stacey Rentschler, David M. Zhang
Publikováno v:
Clinical oncology (Royal College of Radiologists (Great Britain)). 33(11)
Radiation therapy is a well-established approach for safely and non-invasively treating solid tumours and benign diseases with high precision and accuracy. Cardiac radiation therapy has recently emerged as a non-invasive treatment option for the mana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ac0b3a58762d53ca41a78f770b8d6d
https://pubmed.ncbi.nlm.nih.gov/34535357
https://pubmed.ncbi.nlm.nih.gov/34535357
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 320(1)
Although diastolic stiffness and relaxation are considered independent chamber properties, the cardio-hemic inertial oscillation that generates E-waves obeys Newton’s law. E-waves vary with heart rate requiring simultaneous change in stiffness and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d946999cf0b57a5d5efa9064a6558a
https://pubmed.ncbi.nlm.nih.gov/33185111
https://pubmed.ncbi.nlm.nih.gov/33185111
Autor:
Christian A. Bermudez, David M. Zhang, Michael A. Acker, Samson Hennessy-Strahs, Pavan Atluri, Jooeun Kang, David J. Restle, Carlo R. Bartoli
Publikováno v:
Circulation. Heart failure. 11(9)
Background Gastrointestinal bleeding from angiodysplasia is a major problem in continuous-flow left ventricular assist device (LVAD) patients. LVAD shear stress causes pathologic degradation of VWF (von Willebrand factor). A mechanistic relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721b4d9b5620025bbcd572634799bcbc
https://pubmed.ncbi.nlm.nih.gov/30354369
https://pubmed.ncbi.nlm.nih.gov/30354369
Autor:
Carlo R. Bartoli, David M. Zhang, Cameron Shabahang, Jooeun Kang, Pavan Atluri, David J. Restle, Michael A. Acker
Publikováno v:
JACC: Heart Failure. 3:860-869
Objectives The aim of this study was to investigate a potential therapy for left ventricular assist device (LVAD)–associated bleeding. Background Nonsurgical bleeding is the most frequent complication of LVAD support. Recent evidence has demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::525b1bccbb21d46b30c139bdfcd04605
https://doi.org/10.1016/j.jchf.2015.06.016
https://doi.org/10.1016/j.jchf.2015.06.016