Zobrazeno 1 - 10
of 225
pro vyhledávání: '"David M. Virshup"'
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110454- (2024)
Summary: Wnts are lipid-modified glycoproteins that play key roles in both embryonic development and adult homeostasis. Wnt signaling is dysregulated in many cancers and preclinical data shows that targeting Wnt biosynthesis and secretion can be effe
Externí odkaz:
https://doaj.org/article/9929fa1ce4b44dc29733e1e11feb70be
Autor:
Joel C. Francisco, David M. Virshup
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Biological systems operate in constant communication through shared components and feedback from changes in the environment. Casein kinase 1 (CK1) is a family of protein kinases that functions in diverse biological pathways and its regulation is begi
Externí odkaz:
https://doaj.org/article/781a4c78cd8b4b838fb2f44a261184bc
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
Wnt signaling regulates the balance between stemness and differentiation in multiple tissues and in cancer. RNF43-mutant pancreatic cancers are dependent on Wnt production, and pharmacologic blockade of the pathway, e.g., by PORCN inhibitors, leads t
Externí odkaz:
https://doaj.org/article/d3ac6d2f47d54c30923a44bed4508295
Autor:
Kenon Chua, Arthur Yi Loong Sim, Eric Yew Meng Yeo, Muhammad Sufyan Bin Masroni, Wah Wah Naw, Sai Mun Leong, Kee Wah Lee, Huey Jin Lim, David M. Virshup, Victor Kwan Min Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4759 (2023)
There is an increasing urgency in the search for new drugs to target high-grade cancers such as osteosarcomas (OS), as these have limited therapeutic options and poor prognostic outlook. Even though key molecular events leading to tumorigenesis are n
Externí odkaz:
https://doaj.org/article/53adbe271dd349ecaaa9c5fe02765a9b
Autor:
Lucy Brunt, Gediminas Greicius, Sally Rogers, Benjamin D. Evans, David M. Virshup, Kyle C. A. Wedgwood, Steffen Scholpp
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Cytonemes are cellular projections known to transfer Wnt ligands between cells, but their regulation remains unclear. Here, the authors show that activation of the planar cell polarity protein Vangl2 generates long and branched cytonemes increasing p
Externí odkaz:
https://doaj.org/article/5ea0c3f9e6304004a8bd71cac78f963e
Autor:
Shiyang Liu, Nathan Harmston, Trudy Lee Glaser, Yunka Wong, Zheng Zhong, Babita Madan, David M. Virshup, Enrico Petretto
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-22 (2020)
Abstract Background Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt sign
Externí odkaz:
https://doaj.org/article/b3c6a64a96b844899270d2ed76e7be32
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Wnt signaling plays a critical role in bone formation, homeostasis, and injury repair. Multiple cell types in bone have been proposed to produce the Wnts required for these processes. The specific role of Wnts produced from cells of hematopoietic ori
Externí odkaz:
https://doaj.org/article/0dd04496b2ff4ec69a07d1b3dd5d7957
Autor:
Jiao Wang, Zhizhi Wang, Tingting Yu, Huan Yang, David M. Virshup, Geert J. P. L. Kops, Sang Hyun Lee, Weihong Zhou, Xin Li, Wenqing Xu, Zihe Rao
Publikováno v:
Protein & Cell, Vol 7, Iss 7, Pp 516-526 (2016)
ABSTRACT Protein phosphatase 2A (PP2A) accounts for the majority of total Ser/Thr phosphatase activities in most cell types and regulates many biological processes. PP2A holoenzymes contain a scaffold A subunit, a catalytic C subunit, and one of the
Externí odkaz:
https://doaj.org/article/7c583d599c59406bb37f7f04074eeff5
Publikováno v:
Frontiers in Neurology, Vol 8 (2017)
An approximately 24-h biological timekeeping mechanism called the circadian clock is present in virtually all light-sensitive organisms from cyanobacteria to humans. The clock system regulates our sleep–wake cycle, feeding–fasting, hormonal secre
Externí odkaz:
https://doaj.org/article/6130b8fae82c4bb98b3951d32a54f17c
Publikováno v:
Biology Open, Vol 2, Iss 5, Pp 479-486 (2013)
Summary BUBR1 is a mitotic phosphoprotein essential for the maintenance of chromosome stability by promoting chromosome congression and proper kinetochore–microtubule (K-fiber) attachment, but the underlying mechanism(s) has remained elusive. Here
Externí odkaz:
https://doaj.org/article/3ae3affaa8824a0cad1bc49829517672