Zobrazeno 1 - 10
of 21
pro vyhledávání: '"David M. Tillman"'
Autor:
Scott Long, Rob Clark, John T. Gray, Jenny McIntosh, Amit C. Nathwani, James A. Allay, Arthur W. Nienhuis, Gael Carney, Andrew M. Davidoff, Paolo Fagone, Susan Sleep, David M. Tillman
Publikováno v:
Human Gene Therapy. 22:595-604
To generate sufficient clinical-grade vector to support a phase I/II clinical trial of adeno-associated virus serotype 8 (AAV8)-mediated factor IX (FIX) gene transfer for hemophilia B, we have developed a large-scale, good manufacturing practice (GMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbad2d6967169b92a7cc27a3ef2fe0c
https://doi.org/10.1089/hum.2010.202
https://doi.org/10.1089/hum.2010.202
Publikováno v:
Cancer Research. 65:7436-7445
The effects of reactive oxygen species (ROS) on tumor necrosis factor–related apoptosis–inducing ligand (TRAIL)–induced apoptosis in solid cancers have yet to be clearly defined. In this study, we found that the classic uncoupler of oxidative p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8400fdb73c4e7e20373401a9103af4
https://doi.org/10.1158/0008-5472.can-04-2628
https://doi.org/10.1158/0008-5472.can-04-2628
Autor:
P. Kellie Turner, Clinton F. Stewart, Lee S. Schwartzberg, Catherine A. Billups, István Peták, David M. Tillman, Janet A. Houghton, Leslie Douglas, John C. Panetta
Publikováno v:
Cancer Chemotherapy and Pharmacology. 53:253-260
The study objectives were to define subcutaneous (s.c.) interferon gamma (IFN-gamma) disposition in patients with gastrointestinal malignancies receiving 5-fluorouracil (5-FU) and leucovorin (LV) and to examine the relationship between IFN-gamma expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55ef587c552982aff017a730ee464cd
https://doi.org/10.1007/s00280-003-0723-8
https://doi.org/10.1007/s00280-003-0723-8
A caspase-8-independent component in TRAIL/Apo-2L-induced cell death in human rhabdomyosarcoma cells
Autor:
M. Anozie, Kinga Szekely Szucs, Darren C. Phillips, David M. Tillman, Leslie Douglas, István Peták, Janet A. Houghton, Reka Vernes, Kamel Izeradjene
Publikováno v:
Cell Death & Differentiation. 10:729-739
Tumor necrosis factor related apoptosis inducing ligand (TRAIL) belongs to the Tumor necrosis factor (TNF) family of death-inducing ligands, and signaling downstream of TRAIL ligation to its receptor(s) remains to be fully elucidated. Components of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aead2c0170923411916260d52202bd6c
https://doi.org/10.1038/sj.cdd.4401232
https://doi.org/10.1038/sj.cdd.4401232
Expression of genes that regulate Fas signalling and Fas-mediated apoptosis in colon carcinoma cells
Publikováno v:
Cell Death & Differentiation. 5:450-457
The expression of genes that regulate Fas-induced apoptosis has been examined in 10 human cultured colon carcinoma cell lines with defined and varied sensitivity to the cytolytic anti-Fas MoAb CH-11. Four lines demonstrated sensitivity to CH-11 (HT29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2d32de314c4af640b3e8a0501edb77
https://doi.org/10.1038/sj.cdd.4400369
https://doi.org/10.1038/sj.cdd.4400369
Publikováno v:
Methods. 11:3-11
Anti-DNA antibodies are a major contributor to the pathogenesis associated with the autoimmune disease systemic lupus erythematosus in mice and human. The accumulation of a large body of structural information on autoimmune anti-DNA antibodies over t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8f0365ca8ffcccd63875068a257a95
https://doi.org/10.1006/meth.1996.0381
https://doi.org/10.1006/meth.1996.0381
Publikováno v:
Archives of Biochemistry and Biophysics. 326:1-7
Eukaryotes synthesize queuosine (nucleoside Q) by the irreversible base-for-base exchange of queuine (Q base) for guanine at tRNA position 34, a reaction catalyzed by tRNA-guanine transglycosylase (TGT). The physiological role of Q remains unknown bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9f7128b61009775cb3423321fe349b
https://doi.org/10.1006/abbi.1996.0039
https://doi.org/10.1006/abbi.1996.0039
Autor:
Jerome M. Seyer, James F. Hainfeld, Mona T. Norcum, David M. Tillman, Deborah A. Wilkinson, Gerald M. Carlson, Tony N. Marion
Publikováno v:
Journal of Molecular Biology. 235:974-982
An epitope of the alpha-subunit of phosphorylase kinase from fast-twitch skeletal muscle was localized to the tips of the bilobal kinase molecule by two types of immunoelectron microscopy. This is the first direct evidence identifying the location of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3164134691699c6434e941ae207f530b
https://doi.org/10.1006/jmbi.1994.1051
https://doi.org/10.1006/jmbi.1994.1051
Publikováno v:
The Journal of Experimental Medicine
Disease activity in systemic lupus erythematosus is closely associated with the appearance of immunoglobulin (Ig)G antibody to native DNA in both humans and mice. Like normal antibody responses, the anti-DNA autoantibody first appears as IgM and then
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08028673323f2f6e44216dd3e224d4b2
https://doi.org/10.1084/jem.176.3.761
https://doi.org/10.1084/jem.176.3.761
Publikováno v:
Immunological Reviews. 128:123-149
Results from our analyses of variable region gene usage among spontaneous anti-DNA antibodies in autoimmune mice have indicated that both the early IgM and later-appearing IgG autoantibodies to DNA are generated by clonally selected B cells. The recu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a208afcdaf7e33a3a98ba39a6d0d13b
https://doi.org/10.1111/j.1600-065x.1992.tb00835.x
https://doi.org/10.1111/j.1600-065x.1992.tb00835.x