Zobrazeno 1 - 10 of 102 pro vyhledávání: '"David M. Thomson"'
1
Akademický článek
16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability
Autor: Rebecca L. Openshaw, David M. Thomson, Greg C. Bristow, Emma J. Mitchell, Judith A. Pratt, Brian J. Morris, Neil Dawson
Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Autism spectrum disorders are more common in males, and have a substantial genetic component. Chromosomal 16p11.2 deletions in particular carry strong genetic risk for autism, yet their neurobiological impact is poorly characterised, particu
Externí odkaz: https://doaj.org/article/a9c33b7142af4f94937b2541091f6e9d
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2
Akademický článek
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
Autor: Jessica Segalés, Eusebio Perdiguero, Antonio L. Serrano, Pedro Sousa-Victor, Laura Ortet, Mercè Jardí, Andrei V. Budanov, Laura Garcia-Prat, Marco Sandri, David M. Thomson, Michael Karin, Jun Hee Lee, Pura Muñoz-Cánoves
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Ageing is associated with muscle atrophy, which negatively impacts quality of life. Here the authors show that expression of sestrins decreases during inactivity and that their overexpression prevents atrophy in mice via modulation of autophagy and p
Externí odkaz: https://doaj.org/article/36ab756e6fc848bfb843ed2f784d654b
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3
Akademický článek
16p11 Duplication Disrupts Hippocampal-Orbitofrontal-Amygdala Connectivity, Revealing a Neural Circuit Endophenotype for Schizophrenia
Autor: Greg C. Bristow, David M. Thomson, Rebecca L. Openshaw, Emma J. Mitchell, Judith A. Pratt, Neil Dawson, Brian J. Morris
Publikováno v: Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Chromosome 16p11.2 duplications dramatically increase risk for schizophrenia, but the mechanisms remain largely unknown. Here, we show that mice with an equivalent genetic mutation (16p11.2 duplication mice) exhibit impaired hippocampal-orbi
Externí odkaz: https://doaj.org/article/7728d8dbc8bd473aafcc7b7820bf4f24
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4
Akademický článek
BRCA1 is a novel regulator of metabolic function in skeletal muscle
Autor: Kathryn C. Jackson, Eva-Karin Gidlund, Jessica Norrbom, Ana P. Valencia, David M. Thomson, Rosemary A. Schuh, P. Darrell Neufer, Espen E. Spangenburg
Publikováno v: Journal of Lipid Research, Vol 55, Iss 4, Pp 668-680 (2014)
Breast cancer type 1 (BRCA1) susceptibility protein is expressed across multiple tissues including skeletal muscle. The overall objective of this investigation was to define a functional role for BRCA1 in skeletal muscle using a translational approac
Externí odkaz: https://doaj.org/article/d025e92e414043399f99f122bd147e06
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10
Exercise, but Not Metformin Prevents Loss of Muscle Function Due to Doxorubicin in Mice Using an In Situ Method
Autor: David M. Thomson, Chad R. Hancock, Erik D. Marchant, Makensie Joann Louw, Amy D Mackay
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9163, p 9163 (2021)
Though effective in treating various types of cancer, the chemotherapeutic doxorubicin (DOX) is associated with skeletal muscle wasting and fatigue. The purpose of this study was to assess muscle function in situ following DOX administration in mice.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7968c2e93187d6dd52927bcb0b1aca2
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