Zobrazeno 1 - 10
of 348
pro vyhledávání: '"David M. Sabatini"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Animals sense and respond to nutrient availability in their environments, a task coordinated in part by the mTOR complex 1 (mTORC1) pathway. mTORC1 regulates growth in response to nutrients and, in mammals, senses specific amino acids throug
Externí odkaz:
https://doaj.org/article/cfc0b44a13e543eb9b38d60685f127f0
Autor:
Celia de la Calle Arregui, Ana Belén Plata-Gómez, Nerea Deleyto-Seldas, Fernando García, Ana Ortega-Molina, Julio Abril-Garrido, Elena Rodriguez, Ivan Nemazanyy, Laura Tribouillard, Alba de Martino, Eduardo Caleiras, Ramón Campos-Olivas, Francisca Mulero, Mathieu Laplante, Javier Muñoz, Mario Pende, Guadalupe Sabio, David M. Sabatini, Alejo Efeyan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and sh
Externí odkaz:
https://doaj.org/article/ede1c5d31c18497daed3a08d29f4a91b
Autor:
Nadia Rasheed, Tatiani B. Lima, Gustavo F. Mercaldi, Andrey F.Z. Nascimento, Ana L.S. Silva, Germanna L. Righetto, Liron Bar‐Peled, Kuang Shen, David M. Sabatini, Fabio C. Gozzo, Ricardo Aparicio, Juliana H.C. Smetana
Publikováno v:
FEBS Open Bio, Vol 9, Iss 9, Pp 1589-1602 (2019)
Ragulator is a pentamer composed of p18, MP1, p14, C7orf59, and hepatitis B virus X‐interacting protein (HBXIP; LAMTOR 1—5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 signaling. Here, we pres
Externí odkaz:
https://doaj.org/article/105087508ad54b549ac83eec6ccc124e
Autor:
G. Jordan Ray, Elizabeth A. Boydston, Emily Shortt, Gregory A. Wyant, Sebastian Lourido, Walter W. Chen, David M. Sabatini
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Peroxisomes are metabolic organelles that perform a diverse array of critical functions in human physiology. Traditional isolation methods for peroxisomes can take more than 1 h to complete and can be laborious to implement. To address this,
Externí odkaz:
https://doaj.org/article/62922f4abfa34ce08a145992e523f901
Autor:
Christopher J. Yuskaitis, Brandon M. Jones, Rachel L. Wolfson, Chloe E. Super, Sameer C. Dhamne, Alexander Rotenberg, David M. Sabatini, Mustafa Sahin, Annapurna Poduri
Publikováno v:
Neurobiology of Disease, Vol 111, Iss , Pp 91-101 (2018)
DEPDC5 is a newly identified epilepsy-related gene implicated in focal epilepsy, brain malformations, and Sudden Unexplained Death in Epilepsy (SUDEP). In vitro, DEPDC5 negatively regulates amino acid sensing by the mTOR complex 1 (mTORC1) pathway, b
Externí odkaz:
https://doaj.org/article/8d170fb56a97490b916b45841e461d6c
Autor:
Alexandre Caron, Mathilde Mouchiroud, Nicolas Gautier, Sébastien M. Labbé, Romain Villot, Laurie Turcotte, Blandine Secco, Guillaume Lamoureux, Michael Shum, Yves Gélinas, André Marette, Denis Richard, David M. Sabatini, Mathieu Laplante
Publikováno v:
Molecular Metabolism, Vol 6, Iss 5, Pp 447-458 (2017)
Objective: The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions into distinct protein complexes (mTORC1 and mTORC2) that regulates growth and metabolism. DEP-domain containing mTOR-interacting protein (DEPTOR) is par
Externí odkaz:
https://doaj.org/article/5b657b32a77b4cd28ae9600da645e499
Autor:
Alexandre Caron, Sébastien M. Labbé, Damien Lanfray, Pierre-Gilles Blanchard, Romain Villot, Christian Roy, David M. Sabatini, Denis Richard, Mathieu Laplante
Publikováno v:
Molecular Metabolism, Vol 5, Iss 2, Pp 102-112 (2016)
Background/Objective: The mechanistic target of rapamycin (mTOR) is a serine–threonine kinase that functions into distinct protein complexes (mTORC1 and mTORC2) that regulate energy homeostasis. DEP-domain containing mTOR-interacting protein (DEPTO
Externí odkaz:
https://doaj.org/article/741054f323994ff1b77677412d06b9cd
Publikováno v:
Cell Reports, Vol 12, Iss 9, Pp 1445-1455 (2015)
mTORC1 controls key processes that regulate cell growth, including mRNA translation, ribosome biogenesis, and autophagy. Environmental amino acids activate mTORC1 by promoting its recruitment to the cytosolic surface of the lysosome, where its kinase
Externí odkaz:
https://doaj.org/article/3ac0e0cefb034548967e7acda8ed0c87
Autor:
Lynne Chantranupong, Rachel L. Wolfson, Jose M. Orozco, Robert A. Saxton, Sonia M. Scaria, Liron Bar-Peled, Eric Spooner, Marta Isasa, Steven P. Gygi, David M. Sabatini
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 1-8 (2014)
Summary: The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell growth that responds to numerous environmental cues. A key input is amino acids, which act through the heterodimeric Rag GTPases (RagA or RagB bound t
Externí odkaz:
https://doaj.org/article/c9bca710a90f4b2a84f1d20f8fd2edb3
Autor:
Walter W. Chen, Kıvanç Birsoy, Maria M. Mihaylova, Harriet Snitkin, Iwona Stasinski, Burcu Yucel, Erol C. Bayraktar, Jan E. Carette, Clary B. Clish, Thijn R. Brummelkamp, David D. Sabatini, David M. Sabatini
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 27-34 (2014)
Mitochondrial respiratory chain disorders are characterized by loss of electron transport chain (ETC) activity. Although the causes of many such diseases are known, there is a lack of effective therapies. To identify genes that confer resistance to s
Externí odkaz:
https://doaj.org/article/5e50b9f9c1bb4934ba26a0443b38d050