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pro vyhledávání: '"David M. Roof"'
Autor:
David M. Roof, Donna M. Gordon
Publikováno v:
Proceedings of the National Academy of Sciences. 98:12515-12520
Kip1p of Saccharomyces cerevisiae is a bipolar kinesin in the conserved bimC kinesin subfamily that mediates mitotic spindle–pole separation. Here, we show that Kip1p is regulated immediately after anaphase initiation by its rapid degradation. Degr
Autor:
Thomas H. Giddings, Mark Winey, Cornelia Kurischko, Manali Mody, David M. Roof, Francis C. Luca
Publikováno v:
Molecular and Cellular Biology. 21:6972-6983
The Saccharomyces cerevisiae mitotic exit network (MEN) is a conserved set of genes that mediate the transition from mitosis to G(1) by regulating mitotic cyclin degradation and the inactivation of cyclin-dependent kinase (CDK). Here, we demonstrate
Autor:
Donna M. Gordon, David M. Roof
Publikováno v:
Journal of Biological Chemistry. 274:28779-28786
Kip1p is a mitotic spindle-associated kinesin-related protein in Saccharomyces cerevisiae that participates in spindle pole separation. Here, we define the domain arrangement and polypeptide composition of the Kip1p holoenzyme. Electron microscopy of
Publikováno v:
The Journal of Cell Biology
We identified two new Saccharomyces cerevisiae kinesin-related genes, KIP1 and KIP2, using polymerase chain reaction primers corresponding to highly conserved regions of the kinesin motor domain. Both KIP proteins are expressed in vivo, but deletion
Publikováno v:
The Journal of Cell Biology
Spindle orientation and nuclear migration are crucial events in cell growth and differentiation of many eukaryotes. Here we show that KIP3, the sixth and final kinesin-related gene in Saccharomyces cerevisiae , is required for migration of the nucleu
Autor:
Robert B. Wilson, David M. Roof
Publikováno v:
Nature genetics. 16(4)
Friedreich's ataxia (FRDA) is an autosomal recessive degenerative disorder that primarily affects the nervous system and heart. Patients with FRDA have point mutations or trinucleotide repeat expansions in both alleies of FRDA, which encodes a protei
Publikováno v:
Cold Spring Harbor symposia on quantitative biology. 56