Zobrazeno 1 - 10
of 30
pro vyhledávání: '"David M. Rock"'
Publikováno v:
Drug Development Research. 41:85-90
Electrophysiological studies of the effects of test compounds on ion channel currents have been useful in the identification of novel therapeutic agents. Here, we examined the use of cultured superior cervical ganglion (SCG) neurons as a model system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24b177c89fbf5f92738e13613c4dfe44
https://doi.org/10.1002/(sici)1098-2299(199706)41:2<85::aid-ddr5>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199706)41:2<85::aid-ddr5>3.0.co
Autor:
David M. Rock, Robert L. Macdonald
Publikováno v:
Annual Review of Pharmacology and Toxicology. 35:463-482
Endogenous polyamines such as spermine and spermidine have multiple effects in the central nervous system and have been suggested to be neurotransmitters or neuromodulators. One effect of the polyamines is to regulate the activity of the N-methyl-D-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972f9bfcc61bb28f8f8c8a2b4263cb5d
https://doi.org/10.1146/annurev.pa.35.040195.002335
https://doi.org/10.1146/annurev.pa.35.040195.002335
Autor:
Thomas Charles Malone, Gregory W. Campbell, Elsebet Ø. Nielsen, Peter A. Boxer, Jorgen Drejer, Christopher F. Bigge, Frank Wätjen, Frank W. Marcoux, David M. Rock, Leif Helth Jensen, Leonard Joseph Lescosky, Linda L. Coughenour
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:371-376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8c346721d74ca36cf753dffe53bc279
https://doi.org/10.1016/s0960-894x(01)80147-5
https://doi.org/10.1016/s0960-894x(01)80147-5
Autor:
Leonard Joseph Lescosky, Peter A. Boxer, Christopher F. Bigge, E. Oe. Nielen, Thomas Charles Malone, David M. Rock, Gregory W. Campbell, Frank W. Marcoux, F. Waetjen, L. H. Jensen, J. Drejer, Linda L. Coughenour
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c38063053e43445d1cf35f12d1ae9f8
https://doi.org/10.1002/chin.199427105
https://doi.org/10.1002/chin.199427105
Autor:
Lain-Yen Hu, Todd R. Ryder, Michael F. Rafferty, Wayne L. Cody, Susan M. Lotarski, George P. Miljanich, Elizabeth Millerman, David M. Rock, Yuntao Song, Sally J. Stoehr, et al. et al.
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9168f94e1be8c7525b03b0036f07e921
https://doi.org/10.1002/chin.199926218
https://doi.org/10.1002/chin.199926218
Autor:
Charles Taylor, David M. Rock, Roy D. Schwarz, M. Duff Davis, Michael J. Callahan, Mark G. Vartanian
Publikováno v:
Drug Development Research. 21:195-215
Experiments were performed to assess the pharmacology of a novel inhibitor of GABA uptake, Cl-966 ([1-[2-[bis 4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, HCl salt; the molecular weight of the free acid is 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c3a4fd392a6e2e7f7191d6ccef9519b
https://doi.org/10.1002/ddr.430210306
https://doi.org/10.1002/ddr.430210306
Autor:
G P Miljanich, Mark L. Weber, David M. Rock, B G Szoke, Lain-Yen Hu, Sally J. Stoehr, Todd Robert Ryder, Michael Sinz, Michael Francis Rafferty, Elizabeth Millerman, Yong-Xiang Wang, Susan M. Lotarski, S. Scott Bowersox, Charles Taylor, M R Feng
Publikováno v:
Journal of medicinal chemistry. 42(20)
In this article, the rationale for the design, synthesis, and biological evaluation of a series of N-type voltage-sensitive calcium channel (VSCC) blockers is described. N-Type VSCC blockers, such as ziconotide, have shown utility in several models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5717d41b5b94e5d2230840d4c36c644a
https://pubmed.ncbi.nlm.nih.gov/10514294
https://pubmed.ncbi.nlm.nih.gov/10514294
Autor:
David M. Rock, Po-Wai Yuen, Sally J. Stoehr, Schelkun Robert Michael, Balazs G. Szoke, Thomas Charles Malone, Katalin Tarczy-Hornoch
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(16)
Voltage activated calcium channel (VACC) blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457c485411969b40711012f0001ff6e2
https://pubmed.ncbi.nlm.nih.gov/10476885
https://pubmed.ncbi.nlm.nih.gov/10476885
Autor:
Elizabeth Millerman, Balazs G. Szoke, Susan M. Lotarski, Michael Francis Rafferty, David M. Rock, George P. Miljanich, Lain-Yen Hu, Todd Robert Ryder, Charles Taylor, Mark L. Weber, Sally J. Stoehr
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(16)
Selective N-Type Voltage Sensitive Calcium Channel (VSCC) antagonists have shown utility in several models of pain and ischemia. We report the structure-activity relationship at the proximal phenyl group in a series of non-peptidyl VSCC blockers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad06e5d10ff3d0b2e50572a570a5a53
https://pubmed.ncbi.nlm.nih.gov/10476886
https://pubmed.ncbi.nlm.nih.gov/10476886
Autor:
David J. Dooley, Charles Taylor, David M. Rock, Sally J. Stoehr, Lain-Yen Hu, George P. Miljanich, Elizabeth Millerman, Joann J. Geer, Susan M. Lotarski, Mark G. Vartanian, Balazs G. Szoke, Michael Francis Rafferty, R. Todd Ryder
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(15)
Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown efficacy in several animal models of stroke and pain. In the process of searching for small molecule N-type calcium channel blockers, we have identified a series of N-methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e325778df2c038aa46c8d2093a6fa49
https://pubmed.ncbi.nlm.nih.gov/10465535
https://pubmed.ncbi.nlm.nih.gov/10465535