Zobrazeno 1 - 10
of 28
pro vyhledávání: '"David M. Pinkerton"'
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 2, Pp o342-o343 (2010)
A sample of the title compound [systematic name: (1aS,2aS,3S,5aS,6aS,7R,7aS,7bS,8R,8aS,10R)-7-hydroxy-3-(1-methoxy-1-methylethyl)-10-(2-methyl-1-propenyl)-1a,5a,6a,7,7a,7b,8,8a-octahydro-2H-8,2a-(epoxymethano)phenanthro[2,3-b:6,7-b′]bisoxirene-2,5(
Externí odkaz:
https://doaj.org/article/0f13eebdf67a4472951fd12211bbd4dd
Autor:
Luke W. Guddat, Jed M. Burns, G. Paul Savage, Sharon Chow, Craig M. Williams, Nada H. Eisa, David M. Pinkerton, Timothy J. Vanden Berg, Ahmed Chadli, Kashish Kainth
Publikováno v:
Chemistry – A European Journal. 25:1451-1455
D-Ring-seco-limonoids (tetranortriterpenoids), such as gedunin and xylogranin B display anti-cancer activity, acting via inhibition of Hsp90 and/or associated chaperon machinery (e.g., p23). Despite this, these natural products have received relative
Publikováno v:
Asian Journal of Organic Chemistry. 6:583-597
The widely occurring tetranortriterpene natural product gedunin has a well-established range of important biological properties. Although this molecule has received substantial semi-synthetic attention from medicinal chemists, it has not received dev
Publikováno v:
Chemistry - A European Journal. 23:2282-2285
Gedunin, first isolated in 1960, displays a remarkable range of biological activity, but has yet to receive dedicated synthetic attention from a ground up construction perspective. Presented herein is a successfully executed approach to the fully fun
Publikováno v:
Organicbiomolecular chemistry. 15(34)
The first seco-casbane, EBC-329, isolated from the Australian rainforest, was synthesised from (+)-2-carene in seven steps. This endeavour not only established the absolute stereochemical assignment as (8R,9S)-EBC-329, but also identified, via photoi
Autor:
Catherine A. Campos, David M. Pinkerton, Brandon L. Ashfeld, Joseph B. Gianino, Antonio J. Lepore
Publikováno v:
The Journal of Organic Chemistry. 79:12083-12095
A titanocene-catalyzed multicomponent coupling is described herein. Using catalytic titanocene, phosphine, and zinc dust, zinc acetylides can be generated from the corresponding iodoalkynes to affect sequential nucleophilic additions to aromatic alde
Publikováno v:
Advanced Synthesis & Catalysis. 355:1500-1504
Herein we describe a direct, multicomponent assembly of 1,5-enynes. The titanocene-catalyzed coupling of an aryl aldehyde, iodoalkyne, and allylsilane enables the convergent and rapid synthesis of this versatile architectural motif in good to excelle
Publikováno v:
Organic Letters. 13:5680-5683
The titanocene-catalyzed construction of all-carbon substituted tertiary centers directly from aromatic aldehydes is described. The starting aldehyde behaves as a traceless functionality in the formation of multiple carbon-carbon bonds through consec
Autor:
Matthew T. Jones, David M. Pinkerton, David W. Lupton, David T. J. Loong, Martin G. Banwell, Jayanta K. Ray, Anthony C. Willis
Publikováno v:
Tetrahedron. 66:9252-9262
The Pd[0]-catalyzed Ullmann cross-coupling of o-nitrohaloarenes 1a–e with the brominated heterocycles 2a–f delivers the expected products 3a–j in good to excellent yields. The reductive cyclization of such products, as well as N-acyl derivative
Autor:
Mary J. Garson, David M. Pinkerton, Francisco W.A. Barros, Martin G. Banwell, Manoel Odorico de Moraes, Bruno C. Cavalcanti, Naresh Kumar, Cláudia Pessoa
Publikováno v:
ResearcherID
In the first comprehensive biological assessment of the tambjamine class of marine alkaloids, synthetically derived samples of compounds 1-9 have been subjected to evaluation as antimicrobial agents and screened for their cytotoxic effects on various