Zobrazeno 1 - 10
of 282
pro vyhledávání: '"David M. Ornitz"'
Autor:
Chunsik Lee, Rongyuan Chen, Guangli Sun, Xialin Liu, Xianchai Lin, Chang He, Liying Xing, Lixian Liu, Lasse D. Jensen, Anil Kumar, Harald F. Langer, Xiangrong Ren, Jianing Zhang, Lijuan Huang, Xiangke Yin, JongKyong Kim, Juanhua Zhu, Guanqun Huang, Jiani Li, Weiwei Lu, Wei Chen, Juanxi Liu, Jiaxin Hu, Qihang Sun, Weisi Lu, Lekun Fang, Shasha Wang, Haiqing Kuang, Yihan Zhang, Geng Tian, Jia Mi, Bi-Ang Kang, Masashi Narazaki, Aaron Prodeus, Luc Schoonjans, David M. Ornitz, Jean Gariepy, Guy Eelen, Mieke Dewerchin, Yunlong Yang, Jing-Song Ou, Antonio Mora, Jin Yao, Chen Zhao, Yizhi Liu, Peter Carmeliet, Yihai Cao, Xuri Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs that inhibit VEGF-B together with o
Externí odkaz:
https://doaj.org/article/ad0f2de2f96d45acbb44f158c21c99b6
Autor:
Spencer G. Willet, Nattapon Thanintorn, Helen McNeill, Sung-Ho Huh, David M. Ornitz, Won Jae Huh, Stella G. Hoft, Richard J. DiPaolo, Jason C. Mills
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 325-339 (2023)
Background & Aims: Acute and chronic gastric injury induces alterations in differentiation within the corpus of the stomach called pyloric metaplasia. Pyloric metaplasia is characterized by the death of parietal cells and reprogramming of mitotically
Externí odkaz:
https://doaj.org/article/cabec06a0a304c2999d88643e63e8b04
Autor:
Sophie Patzek, Zhe Liu, Sean de la O, Sean Chang, Lauren E. Byrnes, Xiuqin Zhang, David M. Ornitz, Julie B. Sneddon
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106500- (2023)
Summary: Pancreatic development requires spatially and temporally controlled expression of growth factors derived from mesenchyme. Here, we report that in mice the secreted factor Fgf9 is expressed principally by mesenchyme and then mesothelium durin
Externí odkaz:
https://doaj.org/article/bd0d92840287409786057b307a72e385
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Fibroblast growth factor receptors (FGFRs) are expressed in multiple cell types in the adult heart. Previous studies have shown a cardioprotective effect of some FGF ligands in cardiac ischemia-reperfusion (I/R) injury and a protective role for endot
Externí odkaz:
https://doaj.org/article/16fb64462d824a3c8edf44b4c1542e1d
Autor:
Jingyi Wu, Ye Tian, Lu Han, Chao Liu, Tianyu Sun, Ling Li, Yanlei Yu, Bikash Lamichhane, Rena N. D’Souza, Sarah E. Millar, Robb Krumlauf, David M. Ornitz, Jian Q. Feng, Ophir Klein, Hu Zhao, Fuming Zhang, Robert J. Linhardt, Xiaofang Wang
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-19 (2020)
Abstract Background The formation of supernumerary teeth is an excellent model for studying the molecular mechanisms that control stem/progenitor cell homeostasis needed to generate a renewable source of replacement cells and tissues. Although multip
Externí odkaz:
https://doaj.org/article/d075ac87bfca4c4f89c5fdce533e9fd6
Autor:
Teresa Elo, Päivi H. Lindfors, Qiang Lan, Maria Voutilainen, Ewelina Trela, Claes Ohlsson, Sung-Ho Huh, David M. Ornitz, Matti Poutanen, Beatrice A. Howard, Marja L. Mikkola
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Mammary gland development begins with the appearance of epithelial placodes that invaginate, sprout, and branch to form small arborized trees by birth. The second phase of ductal growth and branching is driven by the highly invasive structur
Externí odkaz:
https://doaj.org/article/5ba55031e3954d0bbbb781c3f97f48b6
Autor:
Yongjun Yin, Xiaodi Ren, Craig Smith, Qianxu Guo, Maria Malabunga, Ilhem Guernah, Yiwei Zhang, Juqun Shen, Haijun Sun, Nabil Chehab, Nick Loizos, Dale L. Ludwig, David M. Ornitz
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 5, Pp 563-571 (2016)
Activating mutations in fibroblast growth factor receptor 3 (FGFR3) have been identified in multiple types of human cancer and in congenital birth defects. In human lung cancer, fibroblast growth factor 9 (FGF9), a high-affinity ligand for FGFR3, is
Externí odkaz:
https://doaj.org/article/5ac0feb2ecbf488585a464818511769e
Autor:
Xianmin Luo, Yujie Fu, Andrew J. Loza, Bhavna Murali, Kathleen M. Leahy, Megan K. Ruhland, Margery Gang, Xinming Su, Ali Zamani, Yu Shi, Kory J. Lavine, David M. Ornitz, Katherine N. Weilbaecher, Fanxin Long, Deborah V. Novack, Roberta Faccio, Gregory D. Longmore, Sheila A. Stewart
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 82-92 (2016)
More than 85% of advanced breast cancer patients suffer from metastatic bone lesions, yet the mechanisms that facilitate these metastases remain poorly understood. Recent studies suggest that tumor-derived factors initiate changes within the tumor mi
Externí odkaz:
https://doaj.org/article/d637abeba09f4ec789b2549d8c87f54d
Autor:
Vikram G. Shakkottai, Maolei Xiao, Lin Xu, Michael Wong, Jeanne M. Nerbonne, David M. Ornitz, Kelvin A. Yamada
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 1, Pp 81-88 (2009)
A missense mutation in the fibroblast growth factor 14 (FGF14) gene underlies SCA27, an autosomal dominant spinocerebellar ataxia in humans. Mice with a targeted disruption of the Fgf14 locus (Fgf14−/−) develop ataxia resembling human SCA27. We t
Externí odkaz:
https://doaj.org/article/e8d85312bcd84e47b33e667b8a349904
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 1, Pp 14-26 (2007)
Spinocerebellar ataxia 27 (SCA27) is a recently described syndrome characterized by impaired cognitive abilities and a slowly progressive ataxia. SCA27 is caused by an autosomal dominant missense mutation in Fibroblast Growth Factor 14 (FGF14). Mice
Externí odkaz:
https://doaj.org/article/33efcca583814141abd13bffbef015b9