Zobrazeno 1 - 10
of 35
pro vyhledávání: '"David M. Lukac"'
Autor:
Jonathan Guito, David M. Lukac
Publikováno v:
Viruses, Vol 7, Iss 1, Pp 72-109 (2015)
In Kaposi’s sarcoma-associated herpesvirus (KSHV) oncogenesis, both latency and reactivation are hypothesized to potentiate tumor growth. The KSHV Rta protein is the lytic switch for reactivation. Rta transactivates essential genes via interactions
Externí odkaz:
https://doaj.org/article/73fdc5d48b40400aa54f634d681ef814
Autor:
Jennifer L. DeCotiis, David M. Lukac
Publikováno v:
Pathogens, Vol 6, Iss 3, p 34 (2017)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of two human cancers, Kaposi’s Sarcoma (KS) and primary effusion lymphoma (PEL), and a lymphoproliferation, Multicentric Castleman’s Disease (MCD). Progression to tumor devel
Externí odkaz:
https://doaj.org/article/a9ea404d11d448b39957469c8f0b18ec
Autor:
Jonathan eGuito, David M. Lukac
Publikováno v:
Frontiers in Microbiology, Vol 3 (2012)
Viruses are obligate intracellular pathogens whose biological success depends upon replication and packaging of viral genomes, and transmission of progeny viruses to new hosts. The biological success of herpesviruses is enhanced by their ability to r
Externí odkaz:
https://doaj.org/article/488bdbebea6e48afaaa9d55f3edba6ba
Autor:
Jennifer DeCotiis-Mauro, Sun M. Han, Helena Mello, Corey Goyeneche, Giuseppina Marchesini-Tovar, Lianhua Jin, Vivian Bellofatto, David M. Lukac
The cellular Notch signal transduction pathway is intimately associated with infections by Kaposi’s sarcoma-associated herpesvirus (KSHV) and other gamma-herpesviruses. RBP-Jk, the cellular DNA binding component of the canonical Notch pathway, is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07520c34f699cb6d89e4eee1d37e7284
https://doi.org/10.1101/2022.10.21.513206
https://doi.org/10.1101/2022.10.21.513206
Autor:
Diana Palmeri, Peicheng Du, Corey Goyeneche, Olga Gonzalez-Lopez, David M. Lukac, Bryan Alexis Vicente-Ortiz, Helena Mello, Hye Jin Shin, Kyla E. Driscoll, Jennifer DeCotiis
Publikováno v:
J Biol Chem
Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) from latency requires the viral transactivator Rta to contact the host protein Jκ recombination signal-binding protein (RBP-Jκ or CSL). RBP-Jκ normally binds DNA sequence-specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3859aa0cb38e28c55e6872cab2b548
https://doi.org/10.1074/jbc.ra118.007331
https://doi.org/10.1074/jbc.ra118.007331
Publikováno v:
Journal of Virological Methods. 247:99-106
Reactivation of Kaposi’s sarcoma-associated herpesvirus (KHSV; also known as Human herpesvirus (HHV)-8) from latency is associated with progression to disease. The primary experimental models for studying KSHV reactivation are B lymphocyte cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6cf97bd705d44e07d66029ac96a047
https://doi.org/10.1016/j.jviromet.2017.04.019
https://doi.org/10.1016/j.jviromet.2017.04.019
Autor:
David M. Lukac, Jennifer DeCotiis
Publikováno v:
Pathogens
Pathogens, Vol 6, Iss 3, p 34 (2017)
Pathogens, Vol 6, Iss 3, p 34 (2017)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of two human cancers, Kaposi’s Sarcoma (KS) and primary effusion lymphoma (PEL), and a lymphoproliferation, Multicentric Castleman’s Disease (MCD). Progression to tumor devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a69cb96a2db87de2635425877eec7f
http://europepmc.org/articles/PMC5617991
http://europepmc.org/articles/PMC5617991
Publikováno v:
Journal of Virology. 88:1281-1292
In primary effusion lymphoma (PEL) cells infected with latent Kaposi's sarcoma-associated herpesvirus (KSHV), the promoter of the viral lytic switch gene, Rta, is organized into bivalent chromatin, similar to cellular developmental switch genes. Hist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea5dfe314674675de8f90de1f857eba
https://doi.org/10.1128/jvi.02665-13
https://doi.org/10.1128/jvi.02665-13
Publikováno v:
Journal of Virology. 88:547-558
Kaposi's sarcoma-associated herpesvirus (KSHV) causes Kaposi's sarcoma and primary effusion lymphoma. KSHV-infected cells are predominantly latent, with a subset undergoing lytic reactivation. Rta is the essential lytic switch protein that reactivate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bf1f465515ef5bb960279202981620
https://doi.org/10.1128/jvi.02877-13
https://doi.org/10.1128/jvi.02877-13
Autor:
David A. Wah, Jennifer B. Palenchar, Patricia Soteropoulos, Rachel Morales, Anish Das, Vivian Bellofatto, Virginie Aris, David M. Lukac, Mahrukh Banday, Wenzhe Liu
Publikováno v:
Molecular and Biochemical Parasitology. 186:139-142
RNA polymerase II (RNAP-II) synthesizes the m(7)G-capped Spliced Leader (SL) RNA and most protein-coding mRNAs in trypanosomes. RNAP-II recruitment to DNA usually requires a set of transcription factors that make sequence-specific contacts near trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361ddb319ab1f94e1359c976582e6c67
https://doi.org/10.1016/j.molbiopara.2012.09.003
https://doi.org/10.1016/j.molbiopara.2012.09.003