Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David M. Keane"'
Autor:
David M. Keane, Emma C. Erlich, Deborah Hartman, Skaison Kim, Brenda Lemos, Rutvij Patel, Kailash C. Bhol, Daniel E. Tracey, Randall Burton, Barbara S. Fox, M. Scott Harris
Publikováno v:
Journal of Crohn's and Colitis. 10:641-649
Background and aims: AVX-470 is an orally administered, bovine-derived, anti-tumour necrosis factor (TNF) antibody with local activity in the gastrointestinal tract. In the first-in-human clinical trial of AVX-470 in active ulcerative colitis, we eva
Autor:
Daniel E. Tracey, Kailash C. Bhol, Brenda Lemos, Shawn Clark, Gregory D. Lyng, Michael S. Quesenberry, Emma C. Erlich, David M. Keane, Amy D. Holdorf, Barbara S. Fox, Lisa D. Schlehuber
Publikováno v:
Inflammatory Bowel Diseases. 19:2273-2281
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which is currently treated with injected monoclonal antibodies specific for tumor necrosis factor (TNF). We developed and characterized AVX-470, a novel
Autor:
Matthew O'Connor, Gretchen M. Argast, Iain J. Mulford, David M. Keane, Julie L.C. Kan, Salam Shaaban, Jonathan A. Pachter, Peter Mercado, David Epstein
Publikováno v:
Cells Tissues Organs. 193:114-132
Epithelial to mesenchymal transition (EMT) plays a dual role in tumor progression. It enhances metastasis of tumor cells by increasing invasive capacity and promoting survival, and it decreases tumor cell sensitivity to epithelial cell-targeting agen
Autor:
Neil W. Gibson, Patricia Beck, Andrew Cooke, Feng-Lei Sun, Vanessa Smith, Michael Vrkljan, Mark Bittner, Mark J. Mulvihill, Anthony Nigro, David M. Keane, Arlindo L. Castelhano, Cara Cesario, Julie L.C. Kan, David L. Emerson, Shannon L. Winski, Mary Srebernak, Christy Nillson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1669-1673
A series of [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines were designed and synthesized as CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBA's).
Autor:
David M. Keane, Susan M. Saporito-Irwin, Jerry P. Melchor, Feng Xu, William E. Van Nostrand, Galina Romanov, Judianne Davis
Publikováno v:
Journal of Biological Chemistry. 277:36392-36398
Deposition of fibrillar amyloid-beta protein (Abeta) in senile plaques and in the walls of cerebral blood vessels is a key pathological feature of Alzheimer's disease and certain related disorders. Fibrillar Abeta deposition is intimately associated
Autor:
Jennie Hauser, Rebecca Rose, Alexander Beko, Feng-Lei Sun, Xiao-Qiong Liu, Charles LeVea, Elizabeth Sharratt, Julie L.C. Kan, Neil W. Gibson, Karen K. Kuropatwinski, Michael G. Brattain, Jing Wang, Lisa E. Brattain, David M. Keane, Ivan Dominquez, Ashwani Rajput
Publikováno v:
The Journal of biological chemistry. 284(16)
Abnormal accumulation and activation of receptor tyrosine kinase Ron (recepteur d'origine nantais) has been demonstrated in a variety of primary human cancers. We show that RNA interference-mediated knockdown of Ron kinase in a highly tumorigenic col
Autor:
Emma C. Erlich, Barbara S. Fox, Kailash C. Bhol, Brenda Lemos, Deborah Hartman, David M. Keane, Daniel E. Tracey
Publikováno v:
Gastroenterology. 146:S-788
Autor:
Kailash C. Bhol, David M. Keane, Barbara S. Fox, Brenda Lemos, Emma C. Erlich, Deborah Hartman, Daniel E. Tracey
Publikováno v:
Inflammatory Bowel Diseases. 19:S19
Autor:
Brenda Lemos, Kailash C. Bhol, David M. Keane, Daniel E. Tracey, Amy D. Holdorf, Shawn Clark, Michael S. Quesenberry, Barbara S. Fox
Publikováno v:
Gastroenterology. 144:S-817
Autor:
David M. Keane, Kailash C. Bhol, Shawn Clark, Brenda Lemos, Michael S. Quesenberry, Daniel E. Tracey, Amy D. Holdorf, Barbara S. Fox
Publikováno v:
Inflammatory Bowel Diseases. 18:S95