Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David M. Jensen"'
Autor:
Hong Xue, Guangyuan Zhang, Aron M. Geurts, Kristie Usa, David M. Jensen, Yong Liu, Michael E. Widlansky, Mingyu Liang
Publikováno v:
EBioMedicine, Vol 35, Iss , Pp 260-269 (2018)
Background: miR-29 is a master regulator of extracellular matrix genes, but conflicting data on its anti-fibrotic effect have been reported. miR-29 improves nitric oxide (NO) production in arterioles by targeting Lypla1. Mir29b1 targeted mutation exa
Externí odkaz:
https://doaj.org/article/2b19ce4c4c1b46209d1dfb0bacf20622
Autor:
David M. Jensen, Peng Han, Lingegowda S. Mangala, Gabriel Lopez-Berestein, Anil K. Sood, Jing Liu, Alison J. Kriegel, Kristie Usa, Michael E. Widlansky, Mingyu Liang
Publikováno v:
Molecular Therapy. 30:3462-3476
MicroRNA miR-29 promotes endothelial function in human arterioles in part by targeting LYPLA1 and increasing nitric oxide production. In addition, miR-29 is a master inhibitor of extracellular matrix gene expression, which may attenuate fibrosis but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83bffd3249f856d528d7d293bb18bd06
https://doi.org/10.1016/j.ymthe.2022.08.007
https://doi.org/10.1016/j.ymthe.2022.08.007
Autor:
Michael E Widlansky, David M Jensen, Jingli Wang, Yong Liu, Aron M Geurts, Alison J Kriegel, Pengyuan Liu, Rong Ying, Guangyuan Zhang, Marc Casati, Chen Chu, Mobin Malik, Amberly Branum, Michael J Tanner, Sudhi Tyagi, Kristie Usa, Mingyu Liang
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 3, Pp 1-14 (2018)
Abstract We investigated the role of microRNAs (miRNA) in endothelial dysfunction in the setting of cardiometabolic disorders represented by type 2 diabetes mellitus (T2DM). miR‐29 was dysregulated in resistance arterioles obtained by biopsy in T2D
Externí odkaz:
https://doaj.org/article/952f272fb18645b9b1998da60a033318
Autor:
Anna Marie Williams, David M. Jensen, Xiaoqing Pan, Pengyuan Liu, Jing Liu, Sean Huls, Kevin R. Regner, Kenneth A. Iczkowski, Feng Wang, Junhui Li, Alexander J. Gallan, Tao Wang, Maria Angeles Baker, Yong Liu, Nava Lalehzari, Mingyu Liang
Publikováno v:
Kidney Int
Pathological heterogeneity is common in clinical tissue specimens and complicates the interpretation of molecular data obtained from the specimen. As a typical example, a kidney biopsy specimen often contains glomeruli and tubulointerstitial regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99181859a1a010ee0021769da79914ee
https://europepmc.org/articles/PMC8940673/
https://europepmc.org/articles/PMC8940673/
Autor:
Anil K. Sood, Alison J. Kriegel, Mingyu Liang, Jing Liu, Selanere Mangala, David M Jensen, Michael E. Widlansky, Kristie Usa
Publikováno v:
Hypertension. 76
MicroRNA miR-29 promotes endothelial function in human arterioles in part by targeting LYPLA1 and increasing nitric oxide production. Endothelial dysfunction is common in cardiovascular diseases such as hypertension and diabetic microvascular complic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6408bdde29dceb480f1099d5568d76e
https://doi.org/10.1161/hyp.76.suppl_1.p245
https://doi.org/10.1161/hyp.76.suppl_1.p245
Autor:
Aron M. Geurts, Yong Liu, Kristie Usa, Hong Xue, David M Jensen, Mingyu Liang, Guangyuan Zhang
Publikováno v:
Hypertension. 72
miR-29 is a master regulator of extracellular matrix genes and is generally considered anti-fibrotic, and it improves nitric oxide (NO) production in human and rat arterioles by targeting Lypla1.Targeted mutation in the Mir29b1 gene exacerbates hyper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49fc51d076b7519db203ba334f8231ef
https://doi.org/10.1161/hyp.72.suppl_1.054
https://doi.org/10.1161/hyp.72.suppl_1.054
Autor:
Jingli Wang, Chen Chu, Rong Ying, Kristie Usa, Marc Casati, Mingyu Liang, Guangyuan Zhang, Sudhi Tyagi, Yong Liu, Mobin Malik, Michael J Tanner, Amberly Branum, Aron M. Geurts, Alison J. Kriegel, David M Jensen, Pengyuan Liu, Michael E. Widlansky
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 3, Pp n/a-n/a (2018)
EMBO Molecular Medicine
EMBO Molecular Medicine
We investigated the role of microRNAs (miRNA) in endothelial dysfunction in the setting of cardiometabolic disorders represented by type 2 diabetes mellitus (T2DM). miR‐29 was dysregulated in resistance arterioles obtained by biopsy in T2DM patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850527d9adbe06b5b4753c30823a8d4f
https://doaj.org/article/952f272fb18645b9b1998da60a033318
https://doaj.org/article/952f272fb18645b9b1998da60a033318
Autor:
David M Jensen, Michael E Widlansky, Mingyu Liang, Jingli Wang, Yong Liu, Aaron Geurts, Alison Kriegel, Pengyuan Liu, Rong Ying, Mobin Malik, Amberly Branum, Michael J Tanner, Kristie Usa, Marc Casati, Guangyuan Zhang, Chen Chu
Publikováno v:
Hypertension. 70
MicroRNA miR-29 is down-regulated in Dahl salt-sensitive (SS) rats compared to salt-insensitive SS-13 BN rats. We investigated the role of miR-29 in endothelial function and the development of hypertension. Using TALENs (Transcriptional Activator-Lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f15b7c669fc470ea3519457a4307c100
https://doi.org/10.1161/hyp.70.suppl_1.059
https://doi.org/10.1161/hyp.70.suppl_1.059
Autor:
Rong Ying, Yong Liu, Allison Couillard, Mingyu Liang, Mobin Malik, Jingli Wang, David M Jensen, Chen Chu, Alison J. Kriegel, Michael E. Widlansky, Pengyuan Liu
Publikováno v:
Hypertension. 66
Background: Studies of experimental models and human blood samples support an important role of microRNAs (miRNAs) in the development of vascular dysfunction in hypertension and diabetes mellitus (DM). Information on miRNA expression in clinically di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edb0e7281aebe69b73454fada4c21fa0
https://doi.org/10.1161/hyp.66.suppl_1.p124
https://doi.org/10.1161/hyp.66.suppl_1.p124