Zobrazeno 1 - 10
of 434
pro vyhledávání: '"David M. Hunt"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The electroretinogram (ERG) measures the electrical activity of retinal neurons and glial cells in response to a light stimulus. Amongst other techniques, clinicians utilize the ERG to diagnose various eye diseases, including inherited conditions suc
Externí odkaz:
https://doaj.org/article/884e0c3effae482aa41a2d9cfe3ee118
Autor:
Jessica K. Mountford, Wayne I. L. Davies, Lyn R. Griffiths, Seyhan Yazar, David A. Mackey, David M. Hunt
Publikováno v:
Molecular Vision, Vol 25, Iss 1, Pp 183-193 (2019)
Purpose: In Bornholm eye disease, a defect in the splicing of transcripts from a variant OPN1LW opsin gene leads to a depletion in spliced transcript levels and, consequently, a reduction in photopigment in photoreceptors expressing the variant gene.
Externí odkaz:
https://doaj.org/article/2ad86b55063e46b2a64c47fd42c153ec
Autor:
Xiaotian Jiang, Rabab Rashwan, Valentina Voigt, Jeanne Nerbonne, David M. Hunt, Livia S. Carvalho
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4877 (2021)
Cone Dystrophy with Supernormal Rod Response (CDSRR) is a rare autosomal recessive disorder leading to severe visual impairment in humans, but little is known about its unique pathophysiology. We have previously shown that CDSRR is caused by mutation
Externí odkaz:
https://doaj.org/article/7abb8e0695e74020a6e557f221cd228a
Autor:
Trevor D. Lamb, David M. Hunt
Publikováno v:
Open Biology, Vol 8, Iss 9 (2018)
We examined the genes encoding the proteins that mediate the Ca-feedback regulatory system in vertebrate rod and cone phototransduction. These proteins comprise four families: recoverin/visinin, the guanylyl cyclase activating proteins (GCAPs), the g
Externí odkaz:
https://doaj.org/article/2a4dd8cf8a33404a9f8a6e32f4d2181a
Publikováno v:
Open Biology, Vol 8, Iss 1 (2018)
Different isoforms of the genes involved in phototransduction are expressed in vertebrate rod and cone photoreceptors, providing a unique example of parallel evolution via gene duplication. In this study, we determine the molecular phylogeny of the p
Externí odkaz:
https://doaj.org/article/fca04b9322984d23adcb524cb9dd2847
Autor:
David M. Hunt, Livia S. Carvalho, Daniel M. A. Pessoa, Jessica K. Mountford, Wayne I. L. Davies
Publikováno v:
Frontiers in Ecology and Evolution, Vol 5 (2017)
Primate color vision is based on two to three cone types in the retina, each expressing a different class of visual pigment, making them the only mammals that possess trichromacy. These pigment classes are the short wavelength-sensitive (SWS1) pigmen
Externí odkaz:
https://doaj.org/article/823dc44dcef94eff895bc791028dc7b1
Publikováno v:
BioTechniques, Vol 43, Iss 6, Pp 785-789 (2007)
We describe a rapid and cost-effective technique for the in vitro removal of introns and other unwanted regions from genomic DNA to generate a single sequence of continuous coding capacity, where tissues required for RNA extraction and complementary
Externí odkaz:
https://doaj.org/article/b378cf302bae46d9bd1168aafe196966
Autor:
Lisa Nivison-Smith, Shaun P. Collin, Yuan Zhu, Sarah Ready, Monica L. Acosta, David M. Hunt, Ian C. Potter, Michael Kalloniatis
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/be3bbeac2e8241a792d9efe53324e826
Autor:
Lucy Kinton, Frederick R Burgess, Stephen Madill, Neeraj Dhaun, Desmond P. Kidd, Peter M Fernandes, David M. Hunt, Helen J. Lachmann, Euan McRorie, Richard J Davenport
Publikováno v:
Practical Neurology. 22:64-70
A 46-year-old man presented with worsening vision in the context of long-standing optic disc changes, bilateral sensorineural hearing loss, chronic aseptic meningitis, rash, arthralgia and raised inflammatory markers. The differential diagnoses of ne
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 473:1455-1468
Light activation of the classical light-sensing retinal neurons, the photoreceptors, results in a graded change in membrane potential that ultimately leads to a reduction in neurotransmitter release to the post-synaptic retinal neurons. Photoreceptor