Zobrazeno 1 - 10
of 93
pro vyhledávání: '"David M. Helfman"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Overexpression or activation of oncogenes or loss of tumor-suppressor genes can induce cellular senescence as a defense mechanism against tumor development, thereby maintaining cellular homeostasis. However, cancer cells can circumvent this
Externí odkaz:
https://doaj.org/article/56fbeca6658f458ab0ef871f85a4091e
AKT drives sustained motility following MEK inhibition via promoting SNAIL and AXL in MDA-MB-231 LM2
Publikováno v:
Biochemical and Biophysical Research Communications. 528:92-98
The adaptive activation of alternative signaling pathways contributes to acquired resistance against targeted cancer therapies. Our previous research has shown that blocking Ras/ERK signaling promotes PI3K/AKT signaling in the lung metastatic derivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c489b2c966e81a52fca40d4c8832b7
https://doi.org/10.1016/j.bbrc.2020.05.043
https://doi.org/10.1016/j.bbrc.2020.05.043
Publikováno v:
Oncotarget
// HyeRim Shin 1 , Dayoung Kim 1 and David M. Helfman 1 1 Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea Correspondence to: David M. Helfman, email: dhelfman@kaist.ac.kr Keywords: col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e4d169e61b4427c520ec24605b2861
https://doi.org/10.18632/oncotarget.19182
https://doi.org/10.18632/oncotarget.19182
Publikováno v:
Oncotarget
// SukYeong Jeong 1 , SunYoung Lim 1 , Galina Schevzov 2 , Peter W. Gunning 2 , David M. Helfman 1 1 Department of Biological Sciences, Korean Advanced Institute of Science and Technology, Daejeon, Republic of Korea 2 Oncology Research Unit, School o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b69b906d5dff3dc50aa568c52f1c4c1
https://doi.org/10.18632/oncotarget.16825
https://doi.org/10.18632/oncotarget.16825
Publikováno v:
Oncotarget
// Cheolwon Choi 1 , Junyeob Kwon 1 , Sunyoung Lim 1 , David M. Helfman 1 1 Department of Biological Sciences, Korean Advanced Institute of Science and Technology, Daejeon, Korea Correspondence to: David M. Helfman, email: dhelfman@kaist.ac.kr Keywor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba87bf772fc9549da76fbd68a3a9b71
https://doi.org/10.18632/oncotarget.11525
https://doi.org/10.18632/oncotarget.11525
Autor:
D Y Kim, David M. Helfman
Publikováno v:
Oncogene. 35:4495-4508
Myosin light chain kinase (MLCK) expression is downregulated in breast cancer, including invasive ductal carcinoma compared with ductal breast carcinoma in situ and metastatic breast tumors. However, little is known about how loss of MLCK expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93200df406007b61de5ddcbd35786b09
https://doi.org/10.1038/onc.2015.508
https://doi.org/10.1038/onc.2015.508
Autor:
Xiaoyu Jiang, Xiaoqing Lu, James Watt, Danuta Szczesna-Cordary, David M. Helfman, Jeffrey R. Moore, Michelle Jones, Izidore S. Lossos, Katarzyna Kazmierczak
Publikováno v:
FEBS Journal. 278:1922-1931
Human germinal center associated lymphoma (HGAL) is a germinal center-specific gene whose expression correlates with a favorable prognosis in patients with diffuse large B-cell and classic Hodgkin lymphomas. HGAL is involved in negative regulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83faf5ee4db5be4f43c4cd2365095fc3
https://doi.org/10.1111/j.1742-4658.2011.08109.x
https://doi.org/10.1111/j.1742-4658.2011.08109.x
Autor:
Patrick G. Flynn, David M. Helfman
Publikováno v:
Journal of Cellular Biochemistry. 110:1365-1375
Non-muscle myosin II (NM II) helps mediate survival and apoptosis in response to TNF-alpha (TNF), however, NM II's mechanism of action in these processes is not fully understood. NM II isoforms are involved in a variety of cellular processes and diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a550a9458ec87ca832bc6265217e67
https://doi.org/10.1002/jcb.22653
https://doi.org/10.1002/jcb.22653
Autor:
Feng Hong, Deborah A. Lannigan, Thiago G. da Silva, Seth A. Wander, Michelle D. Larrea, David M. Helfman, Jeffrey A. Smith, Joyce M. Slingerland
Publikováno v:
Proceedings of the National Academy of Sciences. 106:9268-9273
p90 ribosomal S6 kinase (RSK1) is an effector of both Ras/MEK/MAPK and PI3K/PDK1 pathways. We present evidence that RSK1 drives p27 phosphorylation at T198 to increase RhoA-p27 binding and cell motility. RSK1 activation and p27pT198 both increase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5108ec455b2d8cc2ca8546e48d8407a
https://doi.org/10.1073/pnas.0805057106
https://doi.org/10.1073/pnas.0805057106
Autor:
Izidore S. Lossos, Jun Chen, Raquel Malumbres, David M. Helfman, Xiaoqing Lu, Elena Cubedo Gil
Publikováno v:
Blood. 110:4268-4277
HGAL is a newly identified germinal center (GC)–specific gene whose expression by the tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas. The function of HGAL is unknown. Previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a8e5dd63673805c620e73f1184181e
https://doi.org/10.1182/blood-2007-04-087775
https://doi.org/10.1182/blood-2007-04-087775