Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David M. Guimond"'
Autor:
David M Guimond, Nicholas R Cam, Nupura Hirve, Wei Duan, John D Lambris, Michael Croft, Constantine D Tsoukas
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63645 (2013)
The inducible T cell kinase (ITK) regulates type 2 (Th2) cytokines that provide defense against certain parasitic and bacterial infections and are involved in the pathogenesis of lung inflammation such as allergic asthma. Activation of ITK requires t
Externí odkaz:
https://doaj.org/article/edf470c0afbc4eea888e37cb6147f104
Autor:
Nupura Hirve, Roman M Levytskyy, Stephanie Rigaud, David M Guimond, Tomasz Zal, Karsten Sauer, Constantine D Tsoukas
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45158 (2012)
Binding of the membrane phospholipid phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) to the Pleckstrin Homology (PH) domain of the Tec family protein tyrosine kinase, Inducible T cell Kinase (ITK), is critical for the recruitment of the kinase to t
Externí odkaz:
https://doaj.org/article/97cbf54ebbe84f86a9ad66d1ea411332
Autor:
David M. Guimond, John D. Lambris, Juris A. Grasis, Nicholas R. Cam, Krystal Herman, Paola Magotti, Constantine D. Tsoukas
Publikováno v:
Molecular and Cellular Biology. 30:3596-3609
In vitro data have suggested that activation of the inducible T-cell kinase (ITK) requires an interaction with the adaptor protein SLP-76. One means for this interaction involves binding of the ITK SH3 domain to the polyproline-rich (PR) region of SL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb326d88d2314eda761fa87aff3c29c
https://doi.org/10.1128/mcb.01657-09
https://doi.org/10.1128/mcb.01657-09
Autor:
Lie Min, Constantine D. Tsoukas, Roman M. Levytskyy, Nupura Hirve, Amy H. Andreotti, David M. Guimond
Publikováno v:
Journal of Signal Transduction
ITK-SH3-mediated interactions, both with exogenous ligands and via intermolecular self-association with ITK-SH2, have been shown to be important for regulation of ITK activity. The biological significance of these competing SH3 interactions is not co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306d770860923693abf0cfe0bc033757
Autor:
Wei Duan, Nicholas R. Cam, Constantine D. Tsoukas, Nupura Hirve, John D. Lambris, Michael Croft, David M. Guimond
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63645 (2013)
PLoS ONE
PLoS ONE
The inducible T cell kinase (ITK) regulates type 2 (Th2) cytokines that provide defense against certain parasitic and bacterial infections and are involved in the pathogenesis of lung inflammation such as allergic asthma. Activation of ITK requires t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56861cd6c087f4a51bb5509363861db
https://doi.org/10.1371/journal.pone.0063645
https://doi.org/10.1371/journal.pone.0063645
Autor:
Roman M. Levytskyy, David M. Guimond, Stephanie Rigaud, Constantine D. Tsoukas, Tomasz Zal, Nupura Hirve, Karsten Sauer
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45158 (2012)
PLoS ONE
PLoS ONE
Binding of the membrane phospholipid phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) to the Pleckstrin Homology (PH) domain of the Tec family protein tyrosine kinase, Inducible T cell Kinase (ITK), is critical for the recruitment of the kinase to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8a252319f3a9815f42d3126b046167
https://doi.org/10.1371/journal.pone.0045158
https://doi.org/10.1371/journal.pone.0045158
Autor:
Guimond, David M.1, Cam, Nicholas R.1, Hirve, Nupura1, Duan, Wei2, Lambris, John D.3, Croft, Michael2, Tsoukas, Constantine D.1 ctsoukas@mail.sdsu.edu
Publikováno v:
PLoS ONE. May2013, Vol. 8 Issue 5, p1-10. 10p.
Autor:
Hirve, Nupura1, Levytskyy, Roman M.1, Rigaud, Stephanie2, Guimond, David M.1, Zal, Tomasz3, Sauer, Karsten2, Tsoukas, Constantine D.1 ctsoukas@sciences.sdsu.edu, Cebecauer, Marek4
Publikováno v:
PLoS ONE. Sep2012, Vol. 7 Issue 9, Special section p1-11. 11p.
Autor:
Guimond, David M.
Publikováno v:
Guimond, David M.; & Guimond, David M.(2012). Treatment of experimental asthma using a novel peptide inhibitor of the inducible T cell kinase. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5pb1z1d9
As central regulators of asthma pathogenesis, allergen- specific CD4+ T cells are recruited to the lungs and secrete sustained levels of Th2 cytokines upon reencounter with inhaled allergen leading to the development of the hallmark indicators of ast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::ee25e5b1600d3131b8afb6b54e5ca9c6
http://www.escholarship.org/uc/item/5pb1z1d9
http://www.escholarship.org/uc/item/5pb1z1d9
