Zobrazeno 1 - 10
of 292
pro vyhledávání: '"David M. Gilbert"'
Autor:
Lorenzo Corazzi, Vivien S. Ionasz, Sergej Andrejev, Li-Chin Wang, Athanasios Vouzas, Marco Giaisi, Giulia Di Muzio, Boyu Ding, Anna J. M. Marx, Jonas Henkenjohann, Michael M. Allers, David M. Gilbert, Pei-Chi Wei
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Recurrent DNA break clusters (RDCs) are replication-transcription collision hotspots; many are unique to neural progenitor cells. Through high-resolution replication sequencing and a capture-ligation assay in mouse neural progenitor cells ex
Externí odkaz:
https://doaj.org/article/13d7755a88784e01a7e8da33478c4219
Autor:
Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N. Klein, Mariia Nazarova, Ursula E. Schoeberl, David M. Gilbert, Sara C. B. Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. He
Externí odkaz:
https://doaj.org/article/7e8a67d729464111a78e5ef9b1dc0236
Autor:
Meng Zhang, Mary Elisabeth Ehmann, Srija Matukumalli, Aashutosh Girish Boob, David M. Gilbert, Huimin Zhao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Chromatin boundary elements contribute to the partitioning of mammalian genomes into topological domains to regulate gene expression. Certain boundary elements are adopted as DNA insulators for safe and stable transgene expression in mammali
Externí odkaz:
https://doaj.org/article/66d99c0653d14d1b81af7d501ac5c018
Autor:
Marek Gierlinski, José A. da Costa-Nunes, Emma J. Haagensen, Takayo Sasaki, J. Julian Blow, David M. Gilbert
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: It has been known for many years that in metazoan cells, replication origins are organised into clusters where origins within each cluster fire near-synchronously. Despite clusters being a fundamental organising principle of metazoan DNA
Externí odkaz:
https://doaj.org/article/a76eca10627e41d8ae9b98b575ed5cfc
Autor:
Priscilla S. Redd, Lisette Payero, David M. Gilbert, Clinton A. Page, Reese King, Edward V. McAssey, Dalton Bodie, Stephanie Diaz, C. Nathan Hancock
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Class II DNA transposable elements account for significant portions of eukaryotic genomes and contribute to genome evolution through their mobilization. To escape inactivating mutations and persist in the host genome over evolutionary t
Externí odkaz:
https://doaj.org/article/0c88294b553a472089cd0ae0f64d5fbe
Autor:
Michael B. Heskett, Athanasios E. Vouzas, Leslie G. Smith, Phillip A. Yates, Christopher Boniface, Eric E. Bouhassira, Paul T. Spellman, David M. Gilbert, Mathew J. Thayer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Heskett et al. describe several members of a class of long non-coding RNAs, known as ASARs, which show distinct epigenetic regulation between subclonal lineages and are essential for normal DNA replication timing and stability of human autosomes.
Externí odkaz:
https://doaj.org/article/4e4cb57c90794f0db665eeb98bc386ca
Autor:
Stefano Gnan, Ilya M. Flyamer, Kyle N. Klein, Eleonora Castelli, Alexander Rapp, Andreas Maiser, Naiming Chen, Patrick Weber, Elin Enervald, M. Cristina Cardoso, Wendy A. Bickmore, David M. Gilbert, Sara C. B. Buonomo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
How nuclear architecture overall affects the replication-timing programme is not yet clear. Here the authors reveal RIF1’s dual role as a chromatin-interaction scaffold and regulator of replication timing that allows the coordination of these two a
Externí odkaz:
https://doaj.org/article/051ec9ea54774968bffcfc289db433ad
Autor:
Yuchuan Wang, Yang Zhang, Ruochi Zhang, Tom van Schaik, Liguo Zhang, Takayo Sasaki, Daniel Peric-Hupkes, Yu Chen, David M. Gilbert, Bas van Steensel, Andrew S. Belmont, Jian Ma
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)
Abstract We report SPIN, an integrative computational method to reveal genome-wide intranuclear chromosome positioning and nuclear compartmentalization relative to multiple nuclear structures, which are pivotal for modulating genome function. As a pr
Externí odkaz:
https://doaj.org/article/e008eba1ec264243b115380d6b6da444
Autor:
Marion Cremer, Katharina Brandstetter, Andreas Maiser, Suhas S. P. Rao, Volker J. Schmid, Miguel Guirao-Ortiz, Namita Mitra, Stefania Mamberti, Kyle N. Klein, David M. Gilbert, Heinrich Leonhardt, M. Cristina Cardoso, Erez Lieberman Aiden, Hartmann Harz, Thomas Cremer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The role of cohesin in organizing a functional nuclear architecture remains poorly understood. Here the authors show that cohesin depleted cells pass through endomitosis forming a multilobulated nucleus able to proceed through S-phase with typical fe
Externí odkaz:
https://doaj.org/article/f0e404681d714c6f838a9676235998d2
Autor:
Jing Zhang, Donghoon Lee, Vineet Dhiman, Peng Jiang, Jie Xu, Patrick McGillivray, Hongbo Yang, Jason Liu, William Meyerson, Declan Clarke, Mengting Gu, Shantao Li, Shaoke Lou, Jinrui Xu, Lucas Lochovsky, Matthew Ung, Lijia Ma, Shan Yu, Qin Cao, Arif Harmanci, Koon-Kiu Yan, Anurag Sethi, Gamze Gürsoy, Michael Rutenberg Schoenberg, Joel Rozowsky, Jonathan Warrell, Prashant Emani, Yucheng T. Yang, Timur Galeev, Xiangmeng Kong, Shuang Liu, Xiaotong Li, Jayanth Krishnan, Yanlin Feng, Juan Carlos Rivera-Mulia, Jessica Adrian, James R Broach, Michael Bolt, Jennifer Moran, Dominic Fitzgerald, Vishnu Dileep, Tingting Liu, Shenglin Mei, Takayo Sasaki, Claudia Trevilla-Garcia, Su Wang, Yanli Wang, Chongzhi Zang, Daifeng Wang, Robert J. Klein, Michael Snyder, David M. Gilbert, Kevin Yip, Chao Cheng, Feng Yue, X. Shirley Liu, Kevin P. White, Mark Gerstein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
ENCODE is a resource comprising thousands of functional genomic datasets. Here, the authors present custom annotation within ENCODE for cancer, highlighting a workflow that can help prioritise key elements in oncogenesis.
Externí odkaz:
https://doaj.org/article/d3ef1766b33842a5aa6bd3194efeba4e