Zobrazeno 1 - 10
of 118
pro vyhledávání: '"David M. Gamm"'
Autor:
In-Kyu Lee, Ruosen Xie, Agustin Luz-Madrigal, Seunghwan Min, Jingcheng Zhu, Jiahe Jin, Kimberly L. Edwards, M. Joseph Phillips, Allison L. Ludwig, David M. Gamm, Shaoqin Gong, Zhenqiang Ma
Publikováno v:
Bioactive Materials, Vol 30, Iss , Pp 142-153 (2023)
Age-related macular degeneration (AMD) causes blindness due to loss of retinal pigment epithelium (RPE) and photoreceptors (PRs), which comprise the two outermost layers of the retina. Given the small size of the macula and the importance of direct c
Externí odkaz:
https://doaj.org/article/5fc9b60834c9465ca150b67de55a410f
Autor:
Meha Kabra, Pawan K. Shahi, Yuyuan Wang, Divya Sinha, Allison Spillane, Gregory A. Newby, Shivani Saxena, Yao Tong, Yu Chang, Amr A. Abdeen, Kimberly L. Edwards, Cole O. Theisen, David R. Liu, David M. Gamm, Shaoqin Gong, Krishanu Saha, Bikash R. Pattnaik
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Clinical genome editing is emerging for rare disease treatment, but one of the major limitations is the targeting of CRISPR editors’ delivery. We delivered base editors to the retinal pigmented epithelium (RPE) in the mouse eye using silica nanocap
Externí odkaz:
https://doaj.org/article/3120d5bf8bdb4fc3874e0562564f1672
Autor:
Francesca Barone, Juan Amaral, Irina Bunea, Mitra Farnoodian, Rohan Gupta, Rishabh Gupta, Dara Baker, M. Joseph Phillips, Richard J. Blanch, Arvydas Maminishkis, David M. Gamm, Kapil Bharti
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Over 30 million people worldwide suffer from untreatable vision loss and blindness associated with childhood-onset and age-related eye diseases caused by photoreceptor (PR), retinal pigment epithelium (RPE), and choriocapillaris (CC) degeneration. Re
Externí odkaz:
https://doaj.org/article/31aba2db034c4e20911854cd3b29f75e
Autor:
Sarah K. Rempel, Madalynn J. Welch, Allison L. Ludwig, M. Joseph Phillips, Yochana Kancherla, Donald J. Zack, David M. Gamm, Timothy M. Gómez
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110827- (2022)
Summary: Photoreceptors (PRs) are the primary visual sensory cells, and their loss leads to blindness that is currently incurable. Although cell replacement therapy holds promise, success is hindered by our limited understanding of PR axon growth dur
Externí odkaz:
https://doaj.org/article/bd6e215e3ba0463aabe701ded4ab98b5
Autor:
Karl J. Wahlin, Jie Cheng, Shawna L. Jurlina, Melissa K. Jones, Nicholas R. Dash, Anna Ogata, Nawal Kibria, Sunayan Ray, Kiara C. Eldred, Catherine Kim, Jacob S. Heng, Jenny Phillips, Robert J. Johnston, David M. Gamm, Cynthia Berlinicke, Donald J. Zack
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Human pluripotent stem cells (PSCs) represent a powerful tool to investigate human eye development and disease. When grown in 3D, they can self-assemble into laminar organized retinas; however, variation in the size, shape and composition of individu
Externí odkaz:
https://doaj.org/article/9163c7a815ae44529b224062f12f13fe
Autor:
Kirstin B. Langer, Sarah K. Ohlemacher, M. Joseph Phillips, Clarisse M. Fligor, Peng Jiang, David M. Gamm, Jason S. Meyer
Publikováno v:
Stem Cell Reports, Vol 10, Iss 4, Pp 1282-1293 (2018)
Summary: Retinal ganglion cells (RGCs) are the projection neurons of the retina and transmit visual information to postsynaptic targets in the brain. While this function is shared among nearly all RGCs, this class of cell is remarkably diverse, compr
Externí odkaz:
https://doaj.org/article/05bed16f4f6a49e4a9581f6eda731039
Autor:
M. Joseph Phillips, Elizabeth E. Capowski, Andrew Petersen, Alex D. Jansen, Katherine Barlow, Kimberly L. Edwards, David M. Gamm
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Reporter lines generated in human pluripotent stem cells can be highly useful for the analysis of specific cell types and lineages in live cultures. We created the first human rod reporter line using CRISPR/Cas9 genome editing to replace one
Externí odkaz:
https://doaj.org/article/bc6bee677a18423c99acf52dbb951ec4
Autor:
Allison L. Ludwig, Steven J. Mayerl, Yu Gao, Mark Banghart, Cole Bacig, Maria A. Fernandez Zepeda, Xinyu Zhao, David M. Gamm
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(2)
Human pluripotent stem cell (hPSC)-derived retinal organoids (ROs) can efficiently and reproducibly generate retinal neurons that have potential for use in cell replacement strategies [Capowski et al. , Development 146, dev171686 (2019)]. The ability
Autor:
Aindrila Saha, Elizabeth Capowski, Maria A. Fernandez Zepeda, Emma C. Nelson, David M. Gamm, Raunak Sinha
Publikováno v:
Cell Stem Cell
High-definition vision in humans and nonhuman primates is initiated by cone photoreceptors located within a specialized region of the retina called the fovea. Foveal cone death is the ultimate cause of central blindness in numerous retinal dystrophie
Autor:
Meha Kabra, Pawan K. Shahi, Yuyuan Wang, Divya Sinha, Allison Spillane, Gregory A. Newby, Shivani Saxena, Amr A. Abdeen, Kimberly L. Edwards, Cole O. Theisen, David M. Gamm, David R. Liu, Shaoqin Gong, Krishanu Saha, Bikash R. Pattnaik
Leber Congenital Amaurosis (LCA16) is a progressive vision loss disorder caused by point mutations in the KCNJ13 gene, which encodes an inward-rectifying potassium channel, Kir7.1. A nonsense mutation, W53X (c.158G>A), leads to premature truncation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce73b967956c1f0e73ae09d2ad95a92c
https://doi.org/10.1101/2022.07.12.499808
https://doi.org/10.1101/2022.07.12.499808