Zobrazeno 1 - 10
of 111
pro vyhledávání: '"David M. Ferguson"'
Autor:
Peter G. Larson, David M. Ferguson
Publikováno v:
Molbank, Vol 2021, Iss 4, p M1305 (2021)
4-Amino-imidazo-, oxazolo-, and thiazoloquinolines are key structural scaffolds in the design of nucleoside base analogs for use as therapeutic agents. Current strategies for arriving at diverse substitutions at the C6–C9 positions of the thiazolo-
Externí odkaz:
https://doaj.org/article/4fc1aecdefa848d9a1348d095b6fe499
Publikováno v:
Molecules, Vol 27, Iss 9, p 2616 (2022)
Molecular mechanics force field calculations have historically shown significant limitations in modeling the energetic and conformational interconversions of highly substituted furanose rings. This is primarily due to the gauche effect that is not ea
Externí odkaz:
https://doaj.org/article/1a2444eb7bdc4af7be878de1d143d5d1
Autor:
Ruben Ferreira, Roberto Artali, Adam Benoit, Raimundo Gargallo, Ramon Eritja, David M. Ferguson, Yuk Y. Sham, Stefania Mazzini
Publikováno v:
PLoS ONE, Vol 8, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/cf633fe109f3404985e0edd121bcfd4b
Autor:
Nagamani Vunnam, Mu Yang, Chih Hung Lo, Carolyn Paulson, William D. Fiers, Evan Huber, MaryJane Been, David M. Ferguson, Jonathan N. Sachs
Publikováno v:
ACS Bio & Med Chem Au.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::755fe7c99107f5db3d51536314426ce2
https://doi.org/10.1021/acsbiomedchemau.2c00048
https://doi.org/10.1021/acsbiomedchemau.2c00048
Autor:
Tamara A. Kucaba, Drishti Sehgal, Vidhi Khanna, Jayanth Panyam, Thomas S. Griffith, David M. Ferguson, Hyunjoon Kim, Wenqiu Zhang
Publikováno v:
Molecular Pharmaceutics. 17:2109-2124
Activated natural killer (NK) cells can kill malignant tumor cells via granule exocytosis and secretion of IFN-γ, a key regulator of the TH1 response. Thus, mobilization of NK cells can augment cancer immunotherapy, particularly when mediated throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508076e34cd67bdb5a0f5f2ed4267e8d
https://doi.org/10.1021/acs.molpharmaceut.0c00271
https://doi.org/10.1021/acs.molpharmaceut.0c00271
Publikováno v:
Carbery, C M, Woods, R, McAteer, C & Ferguson, D M 2022, ' Missingness Analysis of Manufacturing Systems: A case study ', Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture . https://doi.org/10.1177/09544054221076631
Increasingly manufacturing companies are looking to use sensors to collect data from production lines to help analyse their performance. More rigorous approaches are needed to process and analyse the resulting data, particularly when considering miss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6b7d51bb4e15e3bbb5373d31d4e0d1
https://pure.qub.ac.uk/en/publications/ee171ecb-6f5f-4b63-a025-d6e6a8294ecf
https://pure.qub.ac.uk/en/publications/ee171ecb-6f5f-4b63-a025-d6e6a8294ecf
Autor:
Padmaja Chittepu, Junshu Yang, Adam Benoit, Christine E. Salomon, Yinduo Ji, David M. Ferguson
A series of acridone and xanthone-based compounds bearing 1,2-epoxypropyl or 1,2-propanediol substituents were synthesized and evaluated for activity against MRSA and MSSA bacterial strains. The results indicate a correlation exists between the numbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd9f3c5e0c5c8f3b0ededa4a1e5b9bda
https://doi.org/10.1101/2021.12.10.472175
https://doi.org/10.1101/2021.12.10.472175
Autor:
Mu Yang, Peter G. Larson, Lincoln Brown, John R. Schultz, Tamara A. Kucaba, Thomas S. Griffith, David M. Ferguson
Publikováno v:
Bioorganicmedicinal chemistry letters. 59
Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for treating infectious disease, cancer, and autoimmune disorders. These receptors can adopt both agonist and antagonist binding conformations that switch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6bd48cf622d4327b2e2a852819a078
https://pubmed.ncbi.nlm.nih.gov/35051578
https://pubmed.ncbi.nlm.nih.gov/35051578
The transmembrane protease serine subfamily (TMPRSS) has at least eight members with known protein sequence: TMPRSS2, TMPRRS3, TMPRSS4, TMPRSS5, TMPRSS6, TMPRSS7, TMPRSS9, TMPRSS11, TMPRSS12 and TMPRSS13. A majority of these TMPRSS proteins have key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a8617ce994cd147e58316ab8740c103
https://doi.org/10.1101/2021.06.15.448583
https://doi.org/10.1101/2021.06.15.448583
Autor:
Julia D. Cramer, Matthew R. Bockman, Helena I. Boshoff, Matthew D. Zimmerman, Michael D. Howe, Véronique Dartois, Neeraj K. Mishra, Victor G. Young, Courtney C. Aldrich, Dirk Schnappinger, Nadine Alvarez-Cabrera, David M. Ferguson, Jonathan F. Bean, Sae Woong Park, Joseph T. Jarrett, Peter Larson, Curtis A. Engelhart
Publikováno v:
ACS Infectious Diseases. 5:598-617
The synthesis, absolute stereochemical configuration, complete biological characterization, mechanism of action and resistance, and pharmacokinetic properties of (S)-(−)-acidomycin are described. Acidomycin possesses promising antitubercular activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1906551a4ed57a1d4d6f5edcb025bbb6
https://doi.org/10.1021/acsinfecdis.8b00345
https://doi.org/10.1021/acsinfecdis.8b00345