Zobrazeno 1 - 10
of 57
pro vyhledávání: '"David M. Feldser"'
Autor:
Jonuelle Acosta, Qinglan Li, Nelson F. Freeburg, Nivitha Murali, Alexandra Indeglia, Grant P. Grothusen, Michelle Cicchini, Hung Mai, Amy C. Gladstein, Keren M. Adler, Katherine R. Doerig, Jinyang Li, Miguel Ruiz-Torres, Kimberly L. Manning, Ben Z. Stanger, Luca Busino, Maureen Murphy, Liling Wan, David M. Feldser
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The p53 tumor suppressor regulates multiple context-dependent tumor suppressive programs. Although p53 is mutated in ~90% of small cell lung cancer (SCLC) tumors, how p53 mediates tumor suppression in this context is unknown. Here, using a m
Externí odkaz:
https://doaj.org/article/ff845a6444d4462dbb8f4fdf61c394b3
Autor:
David M. Walter, Amy C. Gladstein, Katherine R. Doerig, Ramakrishnan Natesan, Saravana G. Baskaran, A. Andrea Gudiel, Keren M. Adler, Jonuelle O. Acosta, Douglas C. Wallace, Irfan A. Asangani, David M. Feldser
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
SETD2 inactivation leads to heightened mTORC1 signaling, oxidative metabolism and protein synthesis in KRAS-driven mouse models of lung adenocarcinoma, contributing to the understanding of how SETD2 deficiency drives early and widespread tumor growth
Externí odkaz:
https://doaj.org/article/c2c79fc965134987aff07bf0f609c365
Autor:
Christopher W. Murray, Jennifer J. Brady, Mingqi Han, Hongchen Cai, Min K. Tsai, Sarah E. Pierce, Ran Cheng, Janos Demeter, David M. Feldser, Peter K. Jackson, David B. Shackelford, Monte M. Winslow
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
LKB1 tumour suppressor gene is frequently mutated in lung adenocarcinoma. Here the authors show that in genetically engineered mouse models of lung cancer Lkb1 restoration induces growth arrest and drives neoplastic cells toward a more differentiated
Externí odkaz:
https://doaj.org/article/fac054136b674b659d92c440e9e9e2b2
Autor:
Alex Doan, Julia Arand, Diana Gong, Alexandros P. Drainas, Yan Ting Shue, Myung Chang Lee, Shuyuan Zhang, David M. Walter, Andrea C. Chaikovsky, David M. Feldser, Hannes Vogel, Lukas E. Dow, Jan M. Skotheim, Julien Sage
Publikováno v:
PLoS Genetics, Vol 17, Iss 12 (2021)
The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors where this inactivation promotes tumorigenesis in part by allowing uncontrolled proliferation. RB has been extensively studied, but its mechanisms of
Externí odkaz:
https://doaj.org/article/c1de44c222424f55b2ca3406c6f3a587
Autor:
Michelle Cicchini, Elizabeth L. Buza, Kyra M. Sagal, A. Andrea Gudiel, Amy C. Durham, David M. Feldser
Publikováno v:
Cell Reports, Vol 18, Iss 8, Pp 1958-1969 (2017)
Expression of oncogenic KrasG12D initiates lung adenomas in a mitogen-activated protein kinase (MAPK) signal-dependent manner from only a subset of cell types in the adult mouse lung. Amplification of MAPK signaling is associated with progression to
Externí odkaz:
https://doaj.org/article/18253b216cca47dc9a2732008fcf0a29
Autor:
Shin-Heng Chiou, Caroline Kim-Kiselak, Viviana I. Risca, Megan K. Heimann, Chen-Hua Chuang, Aurora A. Burds, William J. Greenleaf, Tyler E. Jacks, David M. Feldser, Monte M. Winslow
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 2078-2086 (2014)
Conditional gene deletion in mice has contributed immensely to our understanding of many biological and biomedical processes. Despite an increasing awareness of nonprotein-coding functional elements within protein-coding transcripts, current gene-tar
Externí odkaz:
https://doaj.org/article/e7a176c69bed42c0b44d3b2a6e4e8285
Autor:
David M. Feldser, Travis J. Yates, Michelle Cicchini, Caroline Kim-Kiselak, A. Andrea Gudiel, Charuhas Deshpande, John W. Tobias, Elizabeth L. Buza, Olivia S. Venancio, David M. Walter
Supplementary Table 3: Gene ontology analysis for genes deregulated by both Arid1a and Setd2 loss.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4fe00ed8f0169ad9244e103bd52315
https://doi.org/10.1158/0008-5472.22416824.v1
https://doi.org/10.1158/0008-5472.22416824.v1
Autor:
David M. Feldser, Travis J. Yates, Michelle Cicchini, Caroline Kim-Kiselak, A. Andrea Gudiel, Charuhas Deshpande, John W. Tobias, Elizabeth L. Buza, Olivia S. Venancio, David M. Walter
Figure legends for supplementary figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0522efbac8f25153fd945a5558707410
https://doi.org/10.1158/0008-5472.22416839
https://doi.org/10.1158/0008-5472.22416839
Autor:
David M. Feldser, Travis J. Yates, Michelle Cicchini, Caroline Kim-Kiselak, A. Andrea Gudiel, Charuhas Deshpande, John W. Tobias, Elizabeth L. Buza, Olivia S. Venancio, David M. Walter
Chromatin-modifying genes are frequently mutated in human lung adenocarcinoma, but the functional impact of these mutations on disease initiation and progression is not well understood. Using a CRISPR-based approach, we systematically inactivated thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4d8f9067a4b248f9769fb74e9a87ec
https://doi.org/10.1158/0008-5472.c.6509660.v1
https://doi.org/10.1158/0008-5472.c.6509660.v1
Autor:
Marcelo G. Kazanietz, David M. Feldser, Michelle Cicchini, Martín C. Abba, Fernando Benavides, Mariana Cooke, Rachana Garg
Figure S1. Generation of PKCe knockout mice in A/J background.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bafe351f8695eeb399bfd0278d02fe3
https://doi.org/10.1158/0008-5472.22428046.v1
https://doi.org/10.1158/0008-5472.22428046.v1