Zobrazeno 1 - 10
of 27
pro vyhledávání: '"David M. Essayan"'
Autor:
David M. Essayan, Beverly A. Plunkett, Shau Ku Huang, Paola B. Canelos, Naruhito Oda, Allen C. Myers
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 171:12-18
Interleukin (IL)-17F is a recently described human cytokine belonging to the IL-17 gene family, but its in vivo function remains to be determined. To this end, a full-length mouse IL-17F cDNA sequence with a 483-bp coding region sequence was first id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7034ac4b0f330a7e2b97a9c57706ffc
https://doi.org/10.1164/rccm.200406-778oc
https://doi.org/10.1164/rccm.200406-778oc
Autor:
David M. Essayan
Publikováno v:
Journal of Allergy and Clinical Immunology. 108:671-680
Cyclic nucleotide second messengers (cAMP and cGMP) play a central role in signal transduction and regulation of physiologic responses. Their intracellular levels are controlled by the complex superfamily of cyclic nucleotide phosphodiesterase (PDE)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca44414b8bcb99d975811fe9dc60e11
https://doi.org/10.1067/mai.2001.119555
https://doi.org/10.1067/mai.2001.119555
Publikováno v:
Journal of Interferon & Cytokine Research. 20:383-389
Interferon-beta (IFN-beta) inhibits mitogen-induced T cell responses, in part through downregulation of interleukin-12 (IL-12) or upregulation of IL-10. We have reexamined these findings using ragweed (RW) stimulated or tetanus toxoid (TT)-stimulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee417f03f872c573542d729a7da5acc
https://doi.org/10.1089/107999000312324
https://doi.org/10.1089/107999000312324
Autor:
Miriam Burman, M Grous, Mary S. Barnette, Carol D. Manning, David M Essayan, Siegfried B. Christensen, L. B. Cieslinski, Theodore J. Torphy
Publikováno v:
British Journal of Pharmacology. 128:1393-1398
1. Of the four major phosphodiesterase 4 (PDE4) subtypes, PDE4A, PDE4B and PDE4D are widely expressed in human inflammatory cells, including monocytes and T lymphocytes. We explored the functional role of these subtypes using ten subtype-selective PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51a6d705c94ad234a80956c8fada41a2
https://doi.org/10.1038/sj.bjp.0702911
https://doi.org/10.1038/sj.bjp.0702911
Publikováno v:
Journal of Allergy and Clinical Immunology. 104:828-835
Background: Cyclosporin A (CS) and tacrolimus (FK506, FK) are calcineurin antagonists used widely as T-cell immunosuppressants; however, their relative efficacy on antigen-stimulated T-cell subsets remains undefined. Objective: We have examined the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734a32e692f86c4806794edf098e79d5
https://doi.org/10.1016/s0091-6749(99)70294-0
https://doi.org/10.1016/s0091-6749(99)70294-0
Publikováno v:
Journal of Allergy and Clinical Immunology. 103:451-457
Background: IL-4 and IL-13 are related cytokines with similar functional properties. Differential regulation of IL-4 and IL-13 has not been described. Objective: We have examined the effects of IFN-α on antigen-driven proliferation, IL-4 generation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5c2586c42237d658f1ce5ccc1d40df
https://doi.org/10.1016/s0091-6749(99)70470-7
https://doi.org/10.1016/s0091-6749(99)70470-7
Autor:
Christine M. Braun, Anne Kagey-Sobotka, Lawrence M. Lichtenstein, David M. Essayan, Shau Ku Huang
Publikováno v:
Biochemical Pharmacology. 56:871-879
While a differential sensitivity to cyclic AMP (cAMP)-mediated signaling between Th1 and Th2 cells has been hypothesized, differential activity of downstream signaling through cAMP-dependent protein kinase (cAK) isoforms remains unexplored. We herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfa48cc3d1e385513b1eb27ad9ec1a9
https://doi.org/10.1016/s0006-2952(98)00238-x
https://doi.org/10.1016/s0006-2952(98)00238-x
Autor:
Philip S. Norman, David M. Essayan, Christopher F. Nicodemus, Anne Kagey-Sobotka, Lawrence M. Lichtenstein, Gregory V. Marcotte, Christine M. Braun
Publikováno v:
Journal of Allergy and Clinical Immunology. 101:506-513
Background: Peptide therapy targets T cells directly with short peptides containing multiple T-cell receptor epitopes. Murine studies suggest T-cell anergy as the mechanism of action; however, changes in T-cell cytokine profiles may be more relevant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd479a8e834b6ea7b6eead68e8092cd
https://doi.org/10.1016/s0091-6749(98)70358-6
https://doi.org/10.1016/s0091-6749(98)70358-6
Publikováno v:
Methods. 13:69-78
The pathophysiology of allergic disease is multifactorial, involving an intricate network of interactions among cells, mediators, and cytokines. Substantial progress has been made in defining the role of antigen-specific T cells and cytokines in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f568acb14e99c51da3987054c9644e3
https://doi.org/10.1006/meth.1997.0498
https://doi.org/10.1006/meth.1997.0498
Autor:
Christine M. Braun, Anne Kagey-Sobotka, Lawrence M. Lichtenstein, Gregory G. Bashian, Shau Ku Huang, David M. Essayan
Publikováno v:
Journal of Allergy and Clinical Immunology. 100:400-407
Corticosteroids are potent antiinflammatory agents that modulate human T-lymphocyte responses. Controversy remains as to their possible differential effects on Th1 and Th2 subsets. This study explores the kinetics and efficacy of these agents in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b25985ea9f7260dc2a2e7b2ef16d736
https://doi.org/10.1016/s0091-6749(97)70255-0
https://doi.org/10.1016/s0091-6749(97)70255-0