Zobrazeno 1 - 10
of 88
pro vyhledávání: '"David M. Dietz"'
Autor:
Keita Ishiwari, Christopher P. King, Connor D. Martin, Jordan A. Tripi, Anthony M. George, Alexander C. Lamparelli, Apurva S. Chitre, Oksana Polesskaya, Jerry B. Richards, Leah C. Solberg Woods, Amy M. Gancarz, Abraham A. Palmer, David M. Dietz, Suzanne H. Mitchell, Paul J. Meyer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Organisms must regulate their behavior flexibly in the face of environmental challenges. Failure can lead to a host of maladaptive behavioral traits associated with a range of neuropsychiatric disorders, including attention deficit hyperacti
Externí odkaz:
https://doaj.org/article/586ad7aa872542d0899cd03f7eb3bb9d
Autor:
Amy M. Gancarz, Suzanne H. Mitchell, Anthony M. George, Connor D. Martin, Marisa C. Turk, Heather M. Bool, Fahmida Aktar, Francis Kwarteng, Abraham A. Palmer, Paul J. Meyer, Jerry B. Richards, David M. Dietz, Keita Ishiwari
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Choice behavior requires animals to evaluate both short- and long-term advantages and disadvantages of all potential alternatives. Impulsive choice is traditionally measured in laboratory tasks by utilizing delay discounting (DD), a paradigm
Externí odkaz:
https://doaj.org/article/f50d1540ab384c6180c60c3d3277bf91
Autor:
Kateryna Murlanova, Yan Jouroukhin, Ksenia Novototskaya-Vlasova, Shovgi Huseynov, Olga Pletnikova, Michael J. Morales, Yun Guan, Atsushi Kamiya, Dwight E. Bergles, David M. Dietz, Mikhail V. Pletnikov
Publikováno v:
Cells, Vol 12, Iss 10, p 1412 (2023)
Astrocytes express mu/µ opioid receptors, but the function of these receptors remains poorly understood. We evaluated the effects of astrocyte-restricted knockout of µ opioid receptors on reward- and aversion-associated behaviors in mice chronicall
Externí odkaz:
https://doaj.org/article/26d7ea31e0aa4d55a6b9ddc5ba3e91bc
Autor:
Shannon L. Cole, Ramesh Chandra, Maya Harris, Ishan Patel, Torrance Wang, Hyunjae Kim, Leah Jensen, Scott J. Russo, Gustavo Turecki, Amy M. Gancarz-Kausch, David M. Dietz, Mary Kay Lobo
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Mitochondrial function is required for brain energy homeostasis and neuroadaptation. Recent studies demonstrate that cocaine affects mitochondrial dynamics and morphological characteristics within the nucleus accumbens (NAc). Further, mitoch
Externí odkaz:
https://doaj.org/article/9d6dd2987a8d4db7bdc5e26bc0388cab
Autor:
Jennifer A. Martin, Craig T. Werner, Swarup Mitra, Ping Zhong, Zi-Jun Wang, Pedro H. Gobira, Andrew. F. Stewart, Jay Zhang, Kyra Erias, Justin N. Siemian, Devin Hagarty, Lauren E. Mueller, Rachael L. Neve, Jun-Xu Li, Ramesh Chandra, Karen C. Dietz, Mary Kay Lobo, Amy M. Gancarz, Zhen Yan, David M. Dietz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The underlying transcriptional and cellular events mediating the reduction of dendritic spines on medium spiny neurons of the nucleus accumbens (NAc) remains unknown. Here, authors demonstrate that heroin self-administration negatively regulates the
Externí odkaz:
https://doaj.org/article/fd3986183cd145e696e221b400cee251
Autor:
Allyson K. Friedman, Barbara Juarez, Stacy M. Ku, Hongxing Zhang, Rhodora C. Calizo, Jessica J. Walsh, Dipesh Chaudhury, Song Zhang, Angel Hawkins, David M. Dietz, James W. Murrough, Maria Ribadeneira, Erik H. Wong, Rachael L. Neve, Ming-Hu Han
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalize
Externí odkaz:
https://doaj.org/article/27a25b5d540741f383c902474985df50
Autor:
Lara J. Duffney, Ping Zhong, Jing Wei, Emmanuel Matas, Jia Cheng, Luye Qin, Kaijie Ma, David M. Dietz, Yuji Kajiwara, Joseph D. Buxbaum, Zhen Yan
Publikováno v:
Cell Reports, Vol 11, Iss 9, Pp 1400-1413 (2015)
Haploinsufficiency of the Shank3 gene, which encodes a scaffolding protein at glutamatergic synapses, is a highly prevalent and penetrant risk factor for autism. Using combined behavioral, electrophysiological, biochemical, imaging, and molecular app
Externí odkaz:
https://doaj.org/article/f47f0206b53b4948a2ff095b100fdc77
Publikováno v:
Brain Behav Immun
Opioid addiction remains a severe health problem. While substantial insights underlying opioid addiction have been yielded from neuron-centric studies, the contribution of non-neuronal mechanisms to opioid-related behavioral adaptations has begun to
Autor:
Sasha L. Fulton, Swarup Mitra, Ashley E. Lepack, Jennifer A. Martin, Andrew F. Stewart, Jacob Converse, Mason Hochstetler, David M. Dietz, Ian Maze
Publikováno v:
Neuropsychopharmacology. 47:1776-1783
Persistent transcriptional events in ventral tegmental area (VTA) and other reward relevant brain regions contribute to enduring behavioral adaptations that characterize substance use disorder. Recent data from our laboratory indicate that aberrant a
Autor:
Swarup Mitra, Shruthi A. Thomas, Jennifer A. Martin, Jamal Williams, Kristen Woodhouse, Ramesh Chandra, Jun Xu Li, Mary Kay Lobo, Fraser J. Sim, David M. Dietz
Publikováno v:
Psychopharmacology. 239(11)
Chronic pain can be a debilitating condition, leading to profound changes in nearly every aspect of life. However, the reliance on opioids such as oxycodone for pain management is thought to initiate dependence and addiction liability. The neurobiolo