Zobrazeno 1 - 10
of 144
pro vyhledávání: '"David M. Bowen"'
Publikováno v:
Journal of Lipid Research, Vol 7, Iss 3, Pp 379-386 (1966)
The galactoside bond in cerebroside was found to be cleaved by an enzyme in rat and pig brain. Emulsified stearoyl-14C psychosine was used as the substrate and the extent of cleavage was studied by isolating and counting the stearoyl sphingosine (cer
Externí odkaz:
https://doaj.org/article/e7a94a23bf3645c09f97afcd12c1d5bb
Autor:
David M. Bowen, Andrew W. Procter
Publikováno v:
Alzheimer Disease ISBN: 9781003067665
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5021cbd0d783c9c42ff7303f888404
https://doi.org/10.1201/9781003067665-23
https://doi.org/10.1201/9781003067665-23
Autor:
Margaret M. Esiri, David M. Bowen, David Neary, P. Berman, Gordon K. Wilcock, M. E. Appleyard, A. D. Smith
Acetylcholinesterase (AChE) and nonspecific cholinesterase (nsChE) activities of lumbar cere-brospinal fluid (CSF) from patients with a clinical or histological diagnosis of Alzheimer's disease have been compared with those of normal age-matched cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72280f6210877f66a2c98d77482cacb9
https://ora.ox.ac.uk/objects/uuid:c34dfb75-bae8-4b67-bceb-a65fa9e36397
https://ora.ox.ac.uk/objects/uuid:c34dfb75-bae8-4b67-bceb-a65fa9e36397
Publikováno v:
Journal of Neurochemistry. 65:2165-2169
Physostigmine, the acetylcholinesterase inhibitor (0.3 mg/kg, i.m.), increased extracellular glutamate but not aspartate concentrations in the striatum of anaesthetised rats, determined using microdialysis and HPLC. The rise was both tetrodotoxin and
Publikováno v:
Journal of Neural Transmission. 105:839-853
The mismetabolism of amyloid precursor protein (APP), favouring the production of A beta, is considered to be central to the pathogenesis of Alzheimer's disease (AD). However it remains to be established whether the causative factor is the reported t
Publikováno v:
Experimental Neurology. 147:183-191
Experimental lesions and quantitative autoradiography were used to investigate the cellular distribution of neurotransmitter receptors in rats. Lesions were produced by intracortical injections of either volkensin or ricin. However, only the former i
Neuronal Degeneration by Suicide Transport Following Injection of Volkensin into Rat Cerebral Cortex
Publikováno v:
Experimental Neurology. 147:192-203
We have examined the time course of neurodegeneration in subcortical nuclei and other cortical areas known to project to the rat parietal cortex, following unilateral injection of the suicide transport agent, volkensin, into the cortex of one side. D
Publikováno v:
Neurodegeneration. 4:415-424
Experimental lesions using the retrogradely transported toxic lectin, volkensin, were used in conjunction with quantitative autoradiography to investigate the cellular localization of nicotinic and adenosine A 1 receptors. Lesions were produced by un
Autor:
Rudolph E. Tanzi, Paul T. Francis, F E Sherriff, David M. Bowen, Kevin M. Felsenstein, M.-T. Webster, Gopal Thinakaran, Wilma Wasco, Brian Pearce, N Groome
Publikováno v:
Biochemical Journal. 310:95-99
A monoclonal antibody, 3B11, was raised to a novel protein, amyloid precursor-like protein 2, which did not recognize amyloid precursor protein. Multiple bands were detected in human brain fractions and cell lysate by Western blotting, indicating the
Publikováno v:
British Journal of Pharmacology. 115:1169-1174
1. We have investigated an aspect of the regulation of cortical pyramidal neurone activity. Microdialysis was used to assess whether topical application of drugs (in 10 microliter) to fill a burr hole over the frontal cortex, where part of the cortic