Zobrazeno 1 - 4
of 4
pro vyhledávání: '"David M. Bornes"'
Autor:
Sean X. Peng, Michael George Natchus, Timothy R. Baker, Salane L. King, David J. Foltz, David M. Bornes
Publikováno v:
Analytical Chemistry. 72:1913-1917
Bioanalytical methods based on automated solid-phase extraction (SPE) and high-performance liquid chromatography with electrospray tandem mass spectrometry (LC-MS-MS) have been developed and utilized for the determination of MMP inhibitors in plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37129477080dadd43cc866d35fe97280
https://doi.org/10.1021/ac991349b
https://doi.org/10.1021/ac991349b
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 19:343-349
Automated column-switching HPLC methods were developed and utilized for the direct analyses of three hydroxamic acid based metalloprotease inhibitors in rat plasma. These column-switching methods involved the use of a restricted-access media (RAM) pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a82f9fdf1c65c9bc2525a51ba3d517e
https://doi.org/10.1016/s0731-7085(98)00127-7
https://doi.org/10.1016/s0731-7085(98)00127-7
Publikováno v:
Pharmaceutical Research. 15:1414-1418
Purpose. To develop an in vitro cartilage permeation model for cartilage permeability study and to evaluate the effects of molecular hydrophilicity and cartilage location on the permeability of articular cartilage to matrix metalloprotease inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6ee742e02d3d752353b62087ad4c2c
https://doi.org/10.1023/a:1011905806123
https://doi.org/10.1023/a:1011905806123
Autor:
Fei Gu, David M. Bornes, E.B. Hookfin, Glen E. Mieling, Matthew Pokross, Timothy R. Baker, Michael J. Strojnowski, Sandra A. Heitmeyer, Susan M. Garver, Stanislaw Pikul, David J. Foltz, Lily C. Hsieh, Vikram S. Patel, Michael George Natchus, Michael J. Janusz, Biswanath De, Sean X. Peng, Martin E. Dowty, Charles R. Dietsch, Neil Gregory Almstead, Yetunde Olabisi Taiwo, Roger G. Bookland
Publikováno v:
Journal of medicinal chemistry. 43(26)
A series of hydroxamates was prepared from an aminoproline scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for five enzymes within the MMP family, and a number of inhibitors, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0f2a0b0432bdbaffa16d228b9204e8
https://pubmed.ncbi.nlm.nih.gov/11150165
https://pubmed.ncbi.nlm.nih.gov/11150165