Zobrazeno 1 - 10
of 662
pro vyhledávání: '"David M. Evans"'
Autor:
Sindre Lee-Ødegård, Marit Hjorth, Thomas Olsen, Gunn-Helen Moen, Emily Daubney, David M Evans, Andrea L Hevener, Aldons J Lusis, Mingqi Zhou, Marcus M Seldin, Hooman Allayee, James Hilser, Jonas Krag Viken, Hanne Gulseth, Frode Norheim, Christian A Drevon, Kåre Inge Birkeland
Publikováno v:
eLife, Vol 13 (2024)
Background: Physical activity has been associated with preventing the development of type 2 diabetes and atherosclerotic cardiovascular disease. However, our understanding of the precise molecular mechanisms underlying these effects remains incomplet
Externí odkaz:
https://doaj.org/article/d8371b2a65a34ab0b877c43460d1a3c0
Autor:
Marta R. Moksnes, Ailin F. Hansen, Brooke N. Wolford, Laurent F. Thomas, Humaira Rasheed, Anica Simić, Laxmi Bhatta, Anne Lise Brantsæter, Ida Surakka, Wei Zhou, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Tore Syversen, Jie Zheng, Lars G. Fritsche, David M. Evans, Nicole M. Warrington, Therese H. Nøst, Bjørn Olav Åsvold, Trond Peder Flaten, Cristen J. Willer, Kristian Hveem, Ben M. Brumpton
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. Here we report a c
Externí odkaz:
https://doaj.org/article/a7e170131ef54ac2b581216700d4d812
Autor:
Caroline Brito Nunes, Maria Carolina Borges, Rachel M. Freathy, Deborah A. Lawlor, Elisabeth Qvigstad, David M. Evans, Gunn-Helen Moen
Publikováno v:
Metabolites, Vol 14, Iss 9, p 508 (2024)
Background/Objectives: During pregnancy, physiological changes in maternal circulating glucose levels and its metabolism are essential to meet maternal and fetal energy demands. Major changes in glucose metabolism occur throughout pregnancy and consi
Externí odkaz:
https://doaj.org/article/8f33c21fdc2e4c388603a8c2c25a90c6
Autor:
Carolina Medina-Gomez, Benjamin H. Mullin, Alessandra Chesi, Vid Prijatelj, John P. Kemp, Chen Shochat-Carvalho, Katerina Trajanoska, Carol Wang, Raimo Joro, Tavia E. Evans, Katharina E. Schraut, Ruifang Li-Gao, Tarunveer S. Ahluwalia, M. Carola Zillikens, Kun Zhu, Dennis O. Mook-Kanamori, Daniel S. Evans, Maria Nethander, Maria J. Knol, Gudmar Thorleifsson, Ivana Prokic, Babette Zemel, Linda Broer, Fiona E. McGuigan, Natasja M. van Schoor, Sjur Reppe, Mikolaj A. Pawlak, Stuart H. Ralston, Nathalie van der Velde, Mattias Lorentzon, Kari Stefansson, Hieab H. H. Adams, Scott G. Wilson, M. Arfan Ikram, John P. Walsh, Timo A. Lakka, Kaare M. Gautvik, James F. Wilson, Eric S. Orwoll, Cornelia M. van Duijn, Klaus Bønnelykke, Andre G. Uitterlinden, Unnur Styrkársdóttir, Kristina E. Akesson, Timothy D. Spector, Jonathan H. Tobias, Claes Ohlsson, Janine F. Felix, Hans Bisgaard, Struan F. A. Grant, J. Brent Richards, David M. Evans, Bram van der Eerden, Jeroen van de Peppel, Cheryl Ackert-Bicknell, David Karasik, Erika Kague, Fernando Rivadeneira
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analy
Externí odkaz:
https://doaj.org/article/48a29b7a20594248bc9b5e7eb32dd872
Autor:
Emily R. Daubney, BE/BSc, Shannon D’Urso, BAdvSc (Hons), Gabriel Cuellar-Partida, PhD, Dorrilyn Rajbhandari, RN, Elizabeth Peach, MS, Erika de Guzman, BBSc, Colin McArthur, MD, Andrew Rhodes, MD, Jason Meyer, RN, Simon Finfer, MD, John Myburgh, MD, PhD, Jeremy Cohen, MD, PhD, Horst Joachim Schirra, PhD, Balasubramanian Venkatesh, MD, David M. Evans, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 1, p e1030 (2024)
OBJECTIVES:. We sought to assess whether genetic associations with metabolite concentrations in septic shock patients could be used to identify pathways of potential importance for understanding sepsis pathophysiology. DESIGN:. Retrospective multicen
Externí odkaz:
https://doaj.org/article/158ad5eba31446ff8c699b5134a934d5
Autor:
Eshim S. Jami, Anke R. Hammerschlag, Hannah M. Sallis, Zhen Qiao, Ole A. Andreassen, Per M. Magnus, Pål R. Njølstad, Alexandra Havdahl, Jean-Baptiste Pingault, David M. Evans, Marcus R. Munafò, Eivind Ystrom, Meike Bartels, Christel Middeldorp
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-6 (2023)
Abstract Parental genes may indirectly influence offspring psychiatric outcomes through the environment that parents create for their children. These indirect genetic effects, also known as genetic nurture, could explain individual differences in com
Externí odkaz:
https://doaj.org/article/78a09fc9378445a288d3d72bcea7dcc6
Autor:
Benjamin G. Faber, Monika Frysz, Cindy G. Boer, Daniel S. Evans, Raja Ebsim, Kaitlyn A. Flynn, Mischa Lundberg, Lorraine Southam, April Hartley, Fiona R. Saunders, Claudia Lindner, Jennifer S. Gregory, Richard M. Aspden, Nancy E. Lane, Nicholas C. Harvey, David M. Evans, Eleftheria Zeggini, George Davey Smith, Timothy Cootes, Joyce Van Meurs, John P. Kemp, Jonathan H. Tobias
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104759- (2023)
Summary: Background: Hip minimum joint space width (mJSW) provides a proxy for cartilage thickness. This study aimed to conduct a genome-wide association study (GWAS) of mJSW to (i) identify new genetic determinants of mJSW and (ii) identify which mJ
Externí odkaz:
https://doaj.org/article/e65b32b807094d3195f523dc966a7bd4
Autor:
Shannon D’Urso, Pooja Arumugam, Therese Weider, Liang-Dar Hwang, Tom A. Bond, John P. Kemp, Nicole M. Warrington, David M. Evans, Tracy A. O’Mara, Gunn-Helen Moen
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Observational epidemiological studies suggest a link between several factors related to ovulation and reproductive function and endometrial cancer (EC) risk; however, it is not clear whether these relationships are causal, and whe
Externí odkaz:
https://doaj.org/article/893b631401204381b848f44df831d3bb
Autor:
Jian Zhao, Isobel D. Stewart, Denis Baird, Dan Mason, John Wright, Jie Zheng, Tom R. Gaunt, David M. Evans, Rachel M. Freathy, Claudia Langenberg, Nicole M. Warrington, Deborah A. Lawlor, Maria Carolina Borges
Publikováno v:
EBioMedicine, Vol 88, Iss , Pp 104441- (2023)
Summary: Background: Amino acids are key to protein synthesis, energy metabolism, cell signaling and gene expression; however, the contribution of specific maternal amino acids to fetal growth is unclear. Methods: We explored the effect of maternal c
Externí odkaz:
https://doaj.org/article/bad35794bde34138994005c619dd6000
Autor:
Veronika V. Odintsova, Matthew Suderman, Fiona A. Hagenbeek, Doretta Caramaschi, Jouke-Jan Hottenga, René Pool, BIOS Consortium, Conor V. Dolan, Lannie Ligthart, Catharina E. M. van Beijsterveldt, Gonneke Willemsen, Eco J. C. de Geus, Jeffrey J. Beck, Erik A. Ehli, Gabriel Cuellar-Partida, David M. Evans, Sarah E. Medland, Caroline L. Relton, Dorret I. Boomsma, Jenny van Dongen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Handedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study of left-handedness. In a meta-analysis of 3914 adults of w
Externí odkaz:
https://doaj.org/article/aa0c21ef02a64c0a895c88975f37a66d