Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association.

Autor: David M Vossen, Caroline V M Verhagen, Reidar Grénman, Roelof J C Kluin, Marcel Verheij, Michiel W M van den Brekel, Lodewyk F A Wessels, Conchita Vens

Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0206632 (2018)

BACKGROUND:Large cancer genome studies continue to reveal new players in treatment response and tumorigenesis. The discrimination of functional alterations from the abundance of passenger genetic alterations still poses challenges and determines DNA

Externí odkaz: https://doaj.org/article/1ece493379cf446194cdc3f9516511b8

Ovarian cancer-derived copy number alterations signatures are prognostic in chemoradiotherapy-treated head and neck squamous cell carcinoma

Autor: Conchita Vens, Paul B. Essers, Marcel Verheij, C. René Leemans, Michiel W. M. van den Brekel, David M. Vossen, Harry Bartelink, Ruud H. Brakenhoff, Martijn van der Heijden, Reinout H. de Roest

Publikováno v: Essers, P B M, van der Heijden, M, Vossen, D, de Roest, R H, Leemans, C R, Brakenhoff, R H, van den Brekel, M W M, Bartelink, H, Verheij, M & Vens, C 2020, ' Ovarian cancer-derived copy number alterations signatures are prognostic in chemoradiotherapy-treated head and neck squamous cell carcinoma ', International Journal of Cancer, vol. 147, no. 6, pp. 1732-1739 . https://doi.org/10.1002/ijc.32962
International Journal of Cancer
International Journal of Cancer, 147(6), 1732-1739. Wiley-Liss Inc.
International journal of cancer. Journal international du cancer, 147(6), 1732-1739. Wiley-Liss Inc.
International Journal of Cancer, 147(6), 1732-1739. International Union Against Cancer

DNA copy number alterations (CNAs) are frequent in cancer, and recently developed CNA signatures revealed their value in molecular tumor stratification for patient prognosis and platinum resistance prediction in ovarian cancer. Head and neck squamous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28d639c12b483f64b396c4244ad4673
https://research.vumc.nl/en/publications/192930cb-fe8b-48c8-9bb9-0d38c675b376

Genetic factors associated with a poor outcome in head and neck cancer patients receiving definitive chemoradiotherapy

Autor: Paul B. Essers, Martijn van der Heijden, David M. Vossen, Harry Bartelink, Caroline V.M. Verhagen, Conchita Vens, Marcel Verheij, Lodewyk F. A. Wessels, Michiel W. M. van den Brekel

Publikováno v: Cancers, 11(4):445. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 11(4)
Cancers, 11
Cancers
Volume 11
Issue 4
Cancers, 11(4):445. MDPI Multidisciplinary Digital Publishing Institute
Cancers, 11, 4
Vossen, D M, Verhagen, C V M, Van Der Heijden, M, Essers, P B M, Bartelink, H, Verheij, M, Wessels, L F A, Van Den Brekel, M W M & Vens, C 2019, ' Genetic factors associated with a poor outcome in head and neck cancer patients receiving definitive chemoradiotherapy ', Cancers, vol. 11, no. 4, 445 . https://doi.org/10.3390/cancers11040445
Cancers, Vol 11, Iss 4, p 445 (2019)

Contains fulltext : 207152.pdf (Publisher’s version ) (Open Access) About half of advanced stage head and neck squamous cell carcinoma (HNSCC) patients can be cured by chemoradiotherapy. Patient outcome may be partially determined by the genetic al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8eaa3db5e58b5ba50a6f05ed69bb131
https://research.vumc.nl/en/publications/98bcf11b-c102-4589-96a0-5e335a287e58

Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma

Autor: Kerstin Borgmann, Mark J. O'Connor, Volkert B. Wreesmann, Reidar Grénman, Ron M. Kerkhoven, Conchita Vens, Roel J.C. Kluin, Lisanne Mout, Lodewyk F. A. Wessels, Marja Nieuwland, Caroline V.M. Verhagen, David M. Vossen, Martijn van der Heijden, Manon Verwijs-Janssen, Marie-Louise F. van Velthuysen, Arno Velds, Tesa M. Severson, Floor Hageman, Marcel Verheij, Michiel W. M. van den Brekel

Publikováno v: Oncotarget, 9(26), 18198-18213. Impact Journals
Oncotarget, 9, 18198-18213
Oncotarget, 9, 26, pp. 18198-18213
Verhagen, C V M, Vossen, D M, Borgmann, K, Hageman, F, Grénman, R, Verwijs-Jansen, M, Mout, L, Kluin, R J C, Nieuwland, M, Severson, T M, Velds, A, Kerkhoven, R, O'Connor, M J, van der Heijden, M, van Velthuysen, M-L, Verheij, M, Wreesmann, V B, Wessels, L F A, van den Brekel, M W M & Vens, C 2018, ' Fanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma ', Oncotarget, vol. 9, no. 26, pp. 18198-18213 . https://doi.org/10.18632/oncotarget.24797
Oncotarget

Contains fulltext : 193611.pdf (Publisher’s version ) (Open Access) Mutations in Fanconi Anemia or Homologous Recombination (FA/HR) genes can cause DNA repair defects and could therefore impact cancer treatment response and patient outcome. Their f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231fb9d3393d48b5ab7381980f42f12c
https://pure.amc.nl/en/publications/fanconi-anemia-and-homologous-recombination-gene-variants-are-associated-with-functional-dna-repair-defects-in-vitro-and-poor-outcome-in-patients-with-advanced-head-and-neck-squamous-cell-carcinoma(54523a9a-d2ad-44fa-8a4b-9ee055bbd7dc).html

OC-0483: DNA repair defects in squamous cell carcinomas of the head and neck

Autor: Reidar Grénman, Marcel Verheij, L. Wessels, Conchita Vens, Ron M. Kerkhoven, Kerstin Borgmann, M.W.M. van den Brekel, Floor Hageman, David M. Vossen, Caroline V.M. Verhagen

Publikováno v: Radiotherapy and Oncology. 111:S189

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79406ee0f2308762c26c2c87b5374d2d
https://doi.org/10.1016/s0167-8140(15)30588-0