Zobrazeno 1 - 10
of 224
pro vyhledávání: '"David M Virshup"'
Autor:
Amanpreet Kaur, Jun Yi Stanley Lim, Sugunavathi Sepramaniam, Siddhi Patnaik, Nathan Harmston, May Ann Lee, Enrico Petretto, David M Virshup, Babita Madan
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Wnt signaling maintains diverse adult stem cell compartments and is implicated in chemotherapy resistance in cancer. PORCN inhibitors that block Wnt secretion have proven effective in Wnt‐addicted preclinical cancer models and are in clini
Externí odkaz:
https://doaj.org/article/e6cc94805b174024ac08e91805f362b0
Autor:
Jonathan M Philpott, Rajesh Narasimamurthy, Clarisse G Ricci, Alfred M Freeberg, Sabrina R Hunt, Lauren E Yee, Rebecca S Pelofsky, Sarvind Tripathi, David M Virshup, Carrie L Partch
Publikováno v:
eLife, Vol 9 (2020)
Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of CK1 in eukaryotes, little is known about its regulation and the
Externí odkaz:
https://doaj.org/article/b24fcf56b8e544f2a439eb2d0a4668d5
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212711 (2019)
Wnts are a family of secreted palmitoleated glycoproteins that play key roles in cell to cell communication during development and regulate stem cell compartments in adults. Wnt receptors, downstream signaling cascades and target pathways have been e
Externí odkaz:
https://doaj.org/article/68803df216644ed1b05ccd6d976205cb
Autor:
Benjamin Mattes, Yonglong Dang, Gediminas Greicius, Lilian Tamara Kaufmann, Benedikt Prunsche, Jakob Rosenbauer, Johannes Stegmaier, Ralf Mikut, Suat Özbek, Gerd Ulrich Nienhaus, Alexander Schug, David M Virshup, Steffen Scholpp
Publikováno v:
eLife, Vol 7 (2018)
Signaling filopodia, termed cytonemes, are dynamic actin-based membrane structures that regulate the exchange of signaling molecules and their receptors within tissues. However, how cytoneme formation is regulated remains unclear. Here, we show that
Externí odkaz:
https://doaj.org/article/9c85a7ddf36a4601a666711100784529
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177834 (2017)
Circadian rhythms are intrinsic ~24 hour cycles that regulate diverse aspects of physiology, and in turn are regulated by interactions with the external environment. Casein kinase 1 delta (CK1δ, CSNK1D) is a key regulator of the clock, phosphorylati
Externí odkaz:
https://doaj.org/article/6e71a7653f1c44829236d3c2be9ea88b
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110454- (2024)
Summary: Wnts are lipid-modified glycoproteins that play key roles in both embryonic development and adult homeostasis. Wnt signaling is dysregulated in many cancers and preclinical data shows that targeting Wnt biosynthesis and secretion can be effe
Externí odkaz:
https://doaj.org/article/9929fa1ce4b44dc29733e1e11feb70be
Autor:
Tracy M Covey, Simran Kaur, Tina Tan Ong, Kyle D Proffitt, Yonghui Wu, Patrick Tan, David M Virshup
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34532 (2012)
Porcupine (PORCN) is a membrane-bound O-acyl transferase that is required for the palmitoylation of Wnt proteins, and that is essential in diverse Wnt pathways for Wnt-Wntless (WLS) binding, Wnt secretion, and Wnt signaling activity. We tested if POR
Externí odkaz:
https://doaj.org/article/6d803ceca73949ce8406e72b0add2d83
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13545 (2010)
PTEN, a phosphoinositide-3-phosphatase, serves dual roles as a tumor suppressor and regulator of cellular anabolic/catabolic metabolism. Adaptation of a redox-sensitive cysteinyl thiol in PTEN for signal transduction by hydrogen peroxide may have sup
Externí odkaz:
https://doaj.org/article/a60878cab3fd4c3a89365b9924f555e7
Autor:
Rachel Harold, Nikhil K. Tulsian, Rajesh Narasimamurthy, Noelle Yaitanes, Maria G. Ayala Hernandez, Hsiau-Wei Lee, David M. Virshup, Carrie L. Partch
SummaryCasein kinase 1 δ (CK1δ) controls essential biological processes, including circadian rhythms and Wnt signaling, but how its activity is regulated is not well understood. CK1δ is inhibited by autophosphorylation of its intrinsically disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caff44d44467f8309af522754415c828
https://doi.org/10.1101/2023.04.24.538174
https://doi.org/10.1101/2023.04.24.538174
Autor:
Babita Madan, David M. Virshup, Enrico Petretto, Héctor G. Palmer, Oriol Arqués, Jun Yi Stanley Lim, Nathan Harmston
Supplementary Figures 1 and 2 and legends for Table S1, S2 and S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e838a8e85064aeaae82ee876d71b9e
https://doi.org/10.1158/0008-5472.22426750.v1
https://doi.org/10.1158/0008-5472.22426750.v1