Zobrazeno 1 - 10
of 348
pro vyhledávání: '"David M Sabatini"'
Autor:
Yong Yu, Shihong M Gao, Youchen Guan, Pei-Wen Hu, Qinghao Zhang, Jiaming Liu, Bentian Jing, Qian Zhao, David M Sabatini, Monther Abu-Remaileh, Sung Yun Jung, Meng C Wang
Publikováno v:
eLife, Vol 13 (2024)
Lysosomes are active sites to integrate cellular metabolism and signal transduction. A collection of proteins associated with the lysosome mediate these metabolic and signaling functions. Both lysosomal metabolism and lysosomal signaling have been li
Externí odkaz:
https://doaj.org/article/e0e6d3cb9074413abcb47380357cca41
Autor:
Jacob M Winter, Heidi L Fresenius, Corey N Cunningham, Peng Wei, Heather R Keys, Jordan Berg, Alex Bott, Tarun Yadav, Jeremy Ryan, Deepika Sirohi, Sheryl R Tripp, Paige Barta, Neeraj Agarwal, Anthony Letai, David M Sabatini, Matthew L Wohlever, Jared Rutter
Publikováno v:
eLife, Vol 11 (2022)
The tumor suppressor gene PTEN is the second most commonly deleted gene in cancer. Such deletions often include portions of the chromosome 10q23 locus beyond the bounds of PTEN itself, which frequently disrupts adjacent genes. Coincidental loss of PT
Externí odkaz:
https://doaj.org/article/2668821f2b48436287366923def05d35
Autor:
Zhou Yu, Lauren E Surface, Chong Yon Park, Max A Horlbeck, Gregory A Wyant, Monther Abu-Remaileh, Timothy R Peterson, David M Sabatini, Jonathan S Weissman, Erin K O'Shea
Publikováno v:
eLife, Vol 7 (2018)
Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the mevalonate pathway in osteoclas
Externí odkaz:
https://doaj.org/article/5fef22a34a86472285b5e7774ff2a709
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95432 (2014)
The phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) axis plays a central role in attenuating inflammation upon macrophage stimulation with toll-like receptor (TLR) ligands. The mechanistic target of rapamycin complex 2 (mTORC2) relays signal
Externí odkaz:
https://doaj.org/article/f47134a7f954410b88873877d653dc53
Autor:
Max L. Valenstein, Kacper B. Rogala, Pranav V. Lalgudi, Edward J. Brignole, Xin Gu, Robert A. Saxton, Lynne Chantranupong, Jonas Kolibius, Jan-Philipp Quast, David M. Sabatini
Publikováno v:
Nature
The mechanistic target of rapamycin complex 1 (mTORC1) controls growth by regulating anabolic and catabolic processes in response to environmental cues, including nutrients(1,2). Amino acids signal to mTORC1 through the Rag GTPases, which are regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ffc64c0991fb4edf59553b9fc6d7ed
https://doi.org/10.1038/s41586-022-04939-z
https://doi.org/10.1038/s41586-022-04939-z
Publikováno v:
bioRxiv
Animals must sense and respond to nutrient availability in their local niche. This task is coordinated in part by the mTOR complex 1 (mTORC1) pathway, which regulates growth and metabolism in response to nutrients1-5. In mammals, mTORC1 senses specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bace1b7871100bbab0c9908d82e733
https://europepmc.org/articles/PMC10245982/
https://europepmc.org/articles/PMC10245982/
Autor:
David M. Sabatini, Andrew H. Beck, Alexander Jordan, Sumi Sinha, Kuang Shen, Richard Possemato, Kıvanç Birsoy, Valentina Nardi, Brian C. Grabiner
PDF file 73K, mTOR R1208C, V2006L, R2152C, and R2430M fail to confer increased S6K1 phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3da77c4ef2f1f63f12dd716d0ee7a3
https://doi.org/10.1158/2159-8290.22529645.v1
https://doi.org/10.1158/2159-8290.22529645.v1
Autor:
Jonathan E. Rosenberg, Levi A. Garraway, Philip W. Kantoff, Stacey B. Gabriel, Eric S. Lander, David M. Sabatini, Geoffrey I. Shapiro, Massimo Loda, Sabina Signoretti, Edward C. Stack, Mary Ellen Taplin, Aymen A. Elfiky, James M. Cleary, Leena Gandhi, Toni K. Choueiri, Michelle Stewart, Jeffrey G. Supko, Susanna Jacobus, Eran Hodis, Eliezer M. Van Allen, Brian C. Grabiner, Nikhil Wagle
XLSX file 451K, Somatic mutations identified by whole exome sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d74b478dd036d9c182836ded6cdfd8
https://doi.org/10.1158/2159-8290.22530206
https://doi.org/10.1158/2159-8290.22530206
Autor:
David M. Sabatini, Andrew H. Beck, Alexander Jordan, Sumi Sinha, Kuang Shen, Richard Possemato, Kıvanç Birsoy, Valentina Nardi, Brian C. Grabiner
PDF file 106K, S2215Y mTOR activates mTORC1 signaling similar to WT and mutant PI3K-p110alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cfd8ed9d0066143c9c7d8a6113173a
https://doi.org/10.1158/2159-8290.22529654.v1
https://doi.org/10.1158/2159-8290.22529654.v1
Autor:
David M. Sabatini, Andrew H. Beck, Alexander Jordan, Sumi Sinha, Kuang Shen, Richard Possemato, Kıvanç Birsoy, Valentina Nardi, Brian C. Grabiner
PDF file 85K, mTOR pathway mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4427ef55879ae4cdf18d12d00f572fe
https://doi.org/10.1158/2159-8290.22529657.v1
https://doi.org/10.1158/2159-8290.22529657.v1