Zobrazeno 1 - 10
of 162
pro vyhledávání: '"David M Rothstein"'
Autor:
Nicola Gagliani, Silvia Gregori, Tatiana Jofra, Andrea Valle, Angela Stabilini, David M Rothstein, Mark Atkinson, Maria Grazia Roncarolo, Manuela Battaglia
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28434 (2011)
A large pool of preexisting alloreactive effector T cells can cause allogeneic graft rejection following transplantation. However, it is possible to induce transplant tolerance by altering the balance between effector and regulatory T (Treg) cells. A
Externí odkaz:
https://doaj.org/article/369b3ed1ca374f6cae12150233a4d646
Autor:
Zhixing Song, Wenjia Yuan, Leting Zheng, Xingan Wang, Vijay K. Kuchroo, Kanishka Mohib, David M. Rothstein
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
B cells can be polarized to express various cytokines. The roles of IFNγ and IL-10, expressed respectively by B effector 1 (Be1) and Bregs, have been established in pathogen clearance, tumor growth, autoimmunity and allograft rejection. However, the
Externí odkaz:
https://doaj.org/article/59be79daf9634f3a8a489d1be7c09967
Autor:
Sarah Morin-Zorman, Christian Wysocki, Jieqing Zhu, Hongmei Li, Sylvain Zorman, Catherine Matte-Martone, Edwina Kisanga, Jennifer McNiff, Dhanpat Jain, David Gonzalez, David M. Rothstein, Fadi G. Lakkis, Ann Haberman, Warren D. Shlomchik
Publikováno v:
Blood Advances, Vol 3, Iss 14, Pp 2082-2092 (2019)
Abstract: Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (alloSCT). By static microscopy, cutaneous GVHD lesions contain a mix of T cells and myeloid cells. We used 2
Externí odkaz:
https://doaj.org/article/fd7cc965ad0547689fdd3e6ee81d0457
Autor:
Aravind, Cherukuri, David M, Rothstein
Publikováno v:
Current Opinion in Organ Transplantation. 27:385-391
Regulatory B cells (Bregs) play a prominent role in various disease settings. While progress has been hindered by the lack of a specific Breg marker, new findings highlight their role modulating the alloimmune response and promoting allograft surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce111dd8206dec1c4f49da363be7732
https://doi.org/10.1097/mot.0000000000001010
https://doi.org/10.1097/mot.0000000000001010
Autor:
Deviprasad R. Gollapalli, Gregory D. Cuny, Adhar C. Manna, Natalia Maltseva, Barry B. Snider, Yubo Zhang, Mohana Rao Vippila, Ann P. Lawson, Lizbeth Hedstrom, Minjia Zhang, Youngchang Kim, David M Rothstein, Shibin Chacko, Petr Kuzmic, Xingyou Wang, Andrzej Joachimiak, Ryan T Cullinane, Gyan Modi, Gary M Marqus, Ambrose L. Cheung, Judy L.M. Kotler
Publikováno v:
ACS Infectious Diseases. 7:3062-3076
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5'-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a38314a14bd8ed48fa872a866f2505
https://doi.org/10.1021/acsinfecdis.1c00342
https://doi.org/10.1021/acsinfecdis.1c00342
Autor:
Aravind Cherukuri, Khodor I. Abou-Daya, Raad Chowdhury, Rajil B. Mehta, Sundaram Hariharan, Parmjeet Randhawa, David M. Rothstein
Publikováno v:
Kidney international.
Borderline rejection (BL) in renal transplantation is associated with decreased allograft survival, yet many patients with BL maintain stable graft function. Identifying patients with early BL at-risk for shortened allograft survival would allow for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85c92062d76cb597f827acb225d31a5
https://pubmed.ncbi.nlm.nih.gov/36436679
https://pubmed.ncbi.nlm.nih.gov/36436679
Publikováno v:
Immunological reviews
Regulatory B cells (Bregs) ameliorate autoimmune disease and prevent allograft rejection. Conversely, they hinder effective clearance of pathogens and malignancies. Breg activity is mainly attributed to IL-10 expression, but also utilizes additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44292a9bf81837e5a3df43ca0cdf9599
https://doi.org/10.1111/imr.12933
https://doi.org/10.1111/imr.12933
Autor:
Dongwen Wu, Catherine H. Poholek, Saikat Majumder, Qixing Liu, Shankar K. Revu, Kanishka Mohib, David M. Rothstein, Mandy J. McGeachy
Publikováno v:
Sci Immunol
Prior experience of pathogen-associated stimuli reduces morbidity and mortality to newly encountered infections through innate immune training, which can be enhanced by childhood vaccination. Fibroblastic reticular cells (FRCs) are stromal cells in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614079b3953a216280f40525e8ae4a7b
https://doi.org/10.1126/sciimmunol.aao3669
https://doi.org/10.1126/sciimmunol.aao3669
Autor:
Gyan, Modi, Gary M, Marqus, Mohana Rao, Vippila, Deviprasad R, Gollapalli, Youngchang, Kim, Adhar C, Manna, Shibin, Chacko, Natalia, Maltseva, Xingyou, Wang, Ryan T, Cullinane, Yubo, Zhang, Judy L M, Kotler, Petr, Kuzmic, Minjia, Zhang, Ann P, Lawson, Andrzej, Joachimiak, Ambrose, Cheung, Barry B, Snider, David M, Rothstein, Gregory D, Cuny, Lizbeth, Hedstrom
Publikováno v:
ACS Infect Dis
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5’-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ad78a428808eb670c119d890ec480eb
https://pubmed.ncbi.nlm.nih.gov/34590817
https://pubmed.ncbi.nlm.nih.gov/34590817
Autor:
Zhixing, Song, Wenjia, Yuan, Leting, Zheng, Xingan, Wang, Vijay K, Kuchroo, Kanishka, Mohib, David M, Rothstein
Publikováno v:
Frontiers in immunology. 13
B cells can be polarized to express various cytokines. The roles of IFNγ and IL-10, expressed respectively by B effector 1 (Be1) and Bregs, have been established in pathogen clearance, tumor growth, autoimmunity and allograft rejection. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20494c9c084b9f6ce9c436c00955353a
https://pubmed.ncbi.nlm.nih.gov/35359977
https://pubmed.ncbi.nlm.nih.gov/35359977