Zobrazeno 1 - 10
of 64
pro vyhledávání: '"David M Roberts"'
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0205479 (2019)
Tuberculosis is a disease of global importance for which novel drugs are urgently required. We developed a whole-cell phenotypic screen which can be used to identify inhibitors of Mycobacterium tuberculosis growth. We used recombinant strains of viru
Externí odkaz:
https://doaj.org/article/5b33e04ec36148ad939de1b7fbcf3037
Autor:
Kristina N Schaefer, Teresa T Bonello, Shiping Zhang, Clara E Williams, David M Roberts, Daniel J McKay, Mark Peifer
Publikováno v:
PLoS Genetics, Vol 14, Iss 4, p e1007339 (2018)
Wnt signaling provides a paradigm for cell-cell signals that regulate embryonic development and stem cell homeostasis and are inappropriately activated in cancers. The tumor suppressors APC and Axin form the core of the multiprotein destruction compl
Externí odkaz:
https://doaj.org/article/9098cfc7b0864aefb1d87fc3c7ad84fd
Autor:
Stuart Middlemiss, Matthieu Blandenet, David M. Roberts, Andrew McMahon, James Grimshaw, Joshua M. Edwards, Zikai Sun, Kevin D. Whitley, Thierry Blu, Henrik Strahl, Séamus Holden
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Most rod-shaped bacteria elongate by inserting new cell wall material into the inner surface of the cell sidewall. This is performed by class A penicillin binding proteins (PBPs) and a highly conserved protein complex, the elongasome, which
Externí odkaz:
https://doaj.org/article/aa29a5c2d20c4c05b440ebadd6070e85
Autor:
David M Roberts, Mira I Pronobis, Kelly M Alexandre, Gregory C Rogers, John S Poulton, Daniel E Schneider, Kuo-Chen Jung, Daniel J McKay, Mark Peifer
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31284 (2012)
A subset of signaling pathways play exceptionally important roles in embryonic and post-embryonic development, and mis-regulation of these pathways occurs in most human cancers. One such pathway is the Wnt pathway. The primary mechanism keeping Wnt s
Externí odkaz:
https://doaj.org/article/3a58c3515f524fb690e02325ed817220
Autor:
David M. Roberts
Publikováno v:
MicrobiologyOpen, Vol 12, Iss 1, Pp n/a-n/a (2023)
Abstract ParABS (Soj‐Spo0J) systems were initially implicated in plasmid and chromosome segregation in bacteria. However, it is now increasingly understood that they play multiple roles in cell cycle events in Bacillus subtilis, and possibly other
Externí odkaz:
https://doaj.org/article/56d790aadfc34afc8c89186c1c856662
Autor:
Stuart Middlemiss, David M Roberts, James Grimshaw, Joshua M Edwards, Zikai Sun, Kevin D Whitley, Thierry Blu, Henrik Strahl, Séamus Holden
Most rod-shaped bacteria elongate by inserting new cell wall material into the inner surface of the cell sidewall. This is primarily performed by a highly conserved protein complex, the elongasome, which moves processively around the cell circumferen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e15087c3060956780c89888d3f6fd8e1
https://doi.org/10.1101/2023.05.10.540107
https://doi.org/10.1101/2023.05.10.540107
Autor:
David M, Roberts, Anna, Anchimiuk, Tomas G, Kloosterman, Heath, Murray, Ling Juan, Wu, Stephan, Gruber, Jeff, Errington
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(41)
SMC complexes, loaded at ParB
Publikováno v:
IEEE Transactions on Microwave Theory and Techniques. 69:3510-3527
We describe efficient four-coil inductive power transfer (IPT) systems that operate at 100 MHz. The magnetically-coupled transmitter and receiver were made from electrically-small and high-Q loop-gap resonators (LGRs). In contrast to the commonly-use
Autor:
David M. Roberts, Anna Anchimiuk, Tomas G. Kloosterman, Heath Murray, Ling Juan Wu, Stephan Gruber, Jeff Errington
SMC complexes, loaded at ParB-parS sites, are key mediators of chromosome organization in bacteria. ParA/Soj proteins interact with ParB/Spo0J in a pathway involving ATP-dependent dimerization and DNA binding, leading to chromosome segregation and SM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0011df3e4c705674f468a42fdd17cddb
https://doi.org/10.1101/2021.12.18.473321
https://doi.org/10.1101/2021.12.18.473321
Publikováno v:
FEMS Microbiology Letters
Almost all major classes of bacteria are surrounded by a peptidoglycan cell wall, which is a crucial target for antibiotics. It is now understood that many bacteria can tolerate loss of the cell wall provided that they are in an isotonic environment.