Zobrazeno 1 - 10
of 519
pro vyhledávání: '"David M Nanus"'
Autor:
Seaho Kim, CheukMan C Au, Mohd Azrin Bin Jamalruddin, Naira Essam Abou-Ghali, Eiman Mukhtar, Luigi Portella, Adeline Berger, Daniel Worroll, Prerna Vatsa, David S Rickman, David M Nanus, Paraskevi Giannakakou
Publikováno v:
eLife, Vol 11 (2022)
Expression of the AR splice variant, androgen receptor variant 7 (AR-V7), in prostate cancer is correlated with poor patient survival and resistance to AR targeted therapies and taxanes. Currently, there is no specific inhibitor of AR-V7, while the m
Externí odkaz:
https://doaj.org/article/2dbc4df1b5624c61b2a0b3917507799c
Autor:
Johannes C van der Mijn, Bashir Al Hussein Al Awamlh, Aleem Islam Khan, Lina Posada-Calderon, Clara Oromendia, Jonathan Fainberg, Mark Alshak, Rahmi Elahjji, Hudson Pierce, Benjamin Taylor, Lorraine J Gudas, David M Nanus, Ana M Molina, Joseph Del Pizzo, Douglas S Scherr
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226285 (2019)
PurposeTo validate prognostic factors and determine the impact of obesity, hypertension, smoking and diabetes mellitus (DM) on risk of recurrence after surgery in patients with localized renal cell carcinoma (RCC).Materials and methodsWe performed a
Externí odkaz:
https://doaj.org/article/59cde6cecac3483b8106c7e78065e86a
Autor:
Denise R Minton, Leiping Fu, Qiuying Chen, Brian D Robinson, Steven S Gross, David M Nanus, Lorraine J Gudas
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120649 (2015)
Hypoxia inducible factor 1 alpha (HIF1α) is a transcription factor that is frequently stabilized and active in human clear cell renal cell carcinoma (ccRCC). We have found that constitutively active HIF1α is sufficient to cause neoplastic transform
Externí odkaz:
https://doaj.org/article/ce025309fd444532a1a4494c861463aa
Autor:
Scott T Tagawa, Naveed Hassan Akhtar, Anastasia eNikolopoulou, Gurveen eKaur, Brian eRobinson, Renee eKahn, Shankar eVallabhajosula, Stanley J Goldsmith, David M Nanus, Neil H Bander
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
Radioimmunotherapy has demonstrated efficacy with acceptable toxicity leading to approval in non-Hodgkin’s lymphoma, but has been slower to develop for the treatment of advanced solid tumors. Prostate cancer represents a good candidate for radioimm
Externí odkaz:
https://doaj.org/article/f0858c2e01ec4b55954adc87c1b77e65
Autor:
Tahj A. Blow, Anirudh Murthy, Rahul Grover, Emily Schwitzer, David M. Nanus, Darragh Halpenny, Andrew J. Plodkowski, Lee W. Jones, Marcus D. Goncalves
Publikováno v:
European Urology Open Science, Vol 57, Iss , Pp 1-7 (2023)
Background: Androgen deprivation therapy (ADT) is a common treatment modality for men with prostate cancer. Increases in adipose tissue mass and decreases in skeletal muscle mass are known on-target adverse effects of standard ADT. The effects of new
Externí odkaz:
https://doaj.org/article/f9ad575386084e68a42cc7bee697328a
Autor:
Brian J Kirby, Mona Jodari, Matthew S Loftus, Gunjan Gakhar, Erica D Pratt, Chantal Chanel-Vos, Jason P Gleghorn, Steven M Santana, He Liu, James P Smith, Vicente N Navarro, Scott T Tagawa, Neil H Bander, David M Nanus, Paraskevi Giannakakou
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35976 (2012)
Cancer metastasis accounts for the majority of cancer-related deaths owing to poor response to anticancer therapies. Molecular understanding of metastasis-associated drug resistance remains elusive due to the scarcity of available tumor tissue. Isola
Externí odkaz:
https://doaj.org/article/f9fc636b206448c6bdc673cdd65e2d82
Autor:
Ariel E. Marciscano, Sydney Wolfe, Xi Kathy Zhou, Christopher E. Barbieri, Silvia C. Formenti, Jim C. Hu, Ana M. Molina, David M. Nanus, Jones T. Nauseef, Douglas S. Scherr, Cora N. Sternberg, Scott T. Tagawa, Himanshu Nagar
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Ultra-hypofractionated image-guided stereotactic body radiotherapy (SBRT) is increasingly used for definitive treatment of localized prostate cancer. Magnetic resonance imaging-guided radiotherapy (MRgRT) facilitates improved visu
Externí odkaz:
https://doaj.org/article/fa243c6550cd4849bd0e24f9ff480799
Autor:
Johannes C. van der Mijn, Kristian B. Laursen, Leiping Fu, Francesca Khani, Lukas E. Dow, Dawid G. Nowak, Qiuying Chen, Steven S. Gross, David M. Nanus, Lorraine J. Gudas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Genetically engineered mouse models (GEMMs) are important immunocompetent models for research into the roles of individual genes in cancer and the development of novel therapies. Here we use inducible CRISPR-Cas9 systems to develop two GEMMs
Externí odkaz:
https://doaj.org/article/663f362a226d470abe3578034e1b34b8
Autor:
Majd Al Assaad, Nara Shin, Michael Sigouros, Jyothi Manohar, Zoia Antysheva, Nikita Kotlov, Daria Kiriy, Anastasiia Nikitina, Mikhail Kleimenov, Anastasiya Tsareva, Anastasiya Makarova, Victoria Fomchenkova, Julia Dubinina, Alexandra Boyko, Nava Almog, David Wilkes, Joanna G. Escalon, Ashish Saxena, Olivier Elemento, Cora N. Sternberg, David M. Nanus, Juan Miguel Mosquera
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
Cancer of unknown primary (CUP) represents a significant diagnostic and therapeutic challenge, being the third to fourth leading cause of cancer death, despite advances in diagnostic tools. This article presents a successful approach using a novel ge
Externí odkaz:
https://doaj.org/article/13acdf4ab307414bb760f79ae7f83824
Autor:
Jaclyn M. Kubala, Kristian B. Laursen, Ryan Schreiner, Ryan M. Williams, Johannes C. van der Mijn, Michael J. Crowley, Nigel P. Mongan, David M. Nanus, Daniel A. Heller, Lorraine J. Gudas
Publikováno v:
Cancer Biology & Therapy, Vol 24, Iss 1 (2023)
In clear cell renal cell carcinoma (ccRCC), activation of hypoxic signaling induces NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) expression. Over 90% of ccRCCs exhibit overexpression of NDUFA4L2, which we previously showed
Externí odkaz:
https://doaj.org/article/4c9bb11a4e334b73b7320519c6504793